Enriched environment treatment promotes neural functional recovery together with microglia polarization and remyelination after cerebral ischemia in rats
CONCLUSION: EE improved long‑term recovery of cognitive function after cerebral I/R injury, at least in part by promoting M2 microglia transformation through activation of the PI3K/AKT/GSK3β signaling pathway, inhibiting inflammation to provide a favorable microenvironment for oligodendrocyte maturation and remyelination. The effect of the EE on myelin and inflammation could account for the neuroprotection provided by EE.PMID:38423189 | DOI:10.1016/j.brainresbull.2024.110912 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 29, 2024 Category: Neurology Authors: Yu Han Xinya Shen Zhenkun Gao Pingping Han Xia Bi Source Type: research
The role of neuroglial cells communication in ischemic stroke
Brain Res Bull. 2024 Feb 27:110910. doi: 10.1016/j.brainresbull.2024.110910. Online ahead of print.ABSTRACTIschemic stroke is one of the leading causes of death and disability globally, but its treatment options are limited due to therapeutic window and reperfusion injury constraints. Microglia, astrocytes, and oligodendrocytes are the major components of the neurovascular unit, and there is substantial evidence suggesting their contributions to maintaining homeostasis in the central nervous system. Neuroglial cells participate in neuronal physiological functions and the repair of damaged neurons through various communicat...
Source: Brain Research Bulletin - February 29, 2024 Category: Neurology Authors: Yunling Yu Xinglan Liao Xinyu Xie Qihua Li Xuehong Chen Ruizhen Liu Source Type: research
NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at "Zusanli" (ST36)-induced analgesia in ankle arthritis rats
CONCLUSION: These findings strongly suggest that the analgesic mechanism of needling-ST36 on the hypersensation in the lower limb partially relies on NTPDase1 activities in the sciatic nerve. In addition to facilitating adenosine signaling in conjunction with NT5E, most importantly, NTPDase1 may provide an appropriate low-level ATP milieu for the activation of P2Y2R in the sciatic nerve, particularly in Schwann cells.PMID:38402994 | DOI:10.1016/j.brainresbull.2024.110909 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Jing-Wen Xu Si-Qi Tang Jie Lin Yu-Jia Li Dan Shen Guang-Hong Ding Xue-Yong Shen Li-Na Wang Source Type: research
Integrated Analysis of circRNA- related ceRNA Network Targeting Neuroinflammation in Medial Temporal Lobe Epilepsy
CONCLUSIONS: In summary, our study identified a hub ceRNA network and validated a potential circRNA-miRNA-mRNA axis targeting neuroinflammation. The results of our research may serve as a potential therapeutic target for mTLE.PMID:38402995 | DOI:10.1016/j.brainresbull.2024.110908 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Bingzheng Gong Mian Li Ziru Wang Gulingyue Hao Liang Sun Jingjun Zhang Liangjie Yuan Source Type: research
NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at "Zusanli" (ST36)-induced analgesia in ankle arthritis rats
CONCLUSION: These findings strongly suggest that the analgesic mechanism of needling-ST36 on the hypersensation in the lower limb partially relies on NTPDase1 activities in the sciatic nerve. In addition to facilitating adenosine signaling in conjunction with NT5E, most importantly, NTPDase1 may provide an appropriate low-level ATP milieu for the activation of P2Y2R in the sciatic nerve, particularly in Schwann cells.PMID:38402994 | DOI:10.1016/j.brainresbull.2024.110909 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Jing-Wen Xu Si-Qi Tang Jie Lin Yu-Jia Li Dan Shen Guang-Hong Ding Xue-Yong Shen Li-Na Wang Source Type: research
Integrated Analysis of circRNA- related ceRNA Network Targeting Neuroinflammation in Medial Temporal Lobe Epilepsy
CONCLUSIONS: In summary, our study identified a hub ceRNA network and validated a potential circRNA-miRNA-mRNA axis targeting neuroinflammation. The results of our research may serve as a potential therapeutic target for mTLE.PMID:38402995 | DOI:10.1016/j.brainresbull.2024.110908 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Bingzheng Gong Mian Li Ziru Wang Gulingyue Hao Liang Sun Jingjun Zhang Liangjie Yuan Source Type: research
NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at "Zusanli" (ST36)-induced analgesia in ankle arthritis rats
CONCLUSION: These findings strongly suggest that the analgesic mechanism of needling-ST36 on the hypersensation in the lower limb partially relies on NTPDase1 activities in the sciatic nerve. In addition to facilitating adenosine signaling in conjunction with NT5E, most importantly, NTPDase1 may provide an appropriate low-level ATP milieu for the activation of P2Y2R in the sciatic nerve, particularly in Schwann cells.PMID:38402994 | DOI:10.1016/j.brainresbull.2024.110909 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Jing-Wen Xu Si-Qi Tang Jie Lin Yu-Jia Li Dan Shen Guang-Hong Ding Xue-Yong Shen Li-Na Wang Source Type: research
Integrated Analysis of circRNA- related ceRNA Network Targeting Neuroinflammation in Medial Temporal Lobe Epilepsy
CONCLUSIONS: In summary, our study identified a hub ceRNA network and validated a potential circRNA-miRNA-mRNA axis targeting neuroinflammation. The results of our research may serve as a potential therapeutic target for mTLE.PMID:38402995 | DOI:10.1016/j.brainresbull.2024.110908 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Bingzheng Gong Mian Li Ziru Wang Gulingyue Hao Liang Sun Jingjun Zhang Liangjie Yuan Source Type: research
NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at "Zusanli" (ST36)-induced analgesia in ankle arthritis rats
CONCLUSION: These findings strongly suggest that the analgesic mechanism of needling-ST36 on the hypersensation in the lower limb partially relies on NTPDase1 activities in the sciatic nerve. In addition to facilitating adenosine signaling in conjunction with Nt5e, most importantly, NTPDase1 may provide an appropriate low-level ATP milieu for the activation of P2Y2R in the sciatic nerve, particularly in Schwann cells.PMID:38402994 | DOI:10.1016/j.brainresbull.2024.110909 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Jing-Wen Xu Si-Qi Tang Jie Lin Yu-Jia Li Dan Shen Guang-Hong Ding Xue-Yong Shen Li-Na Wang Source Type: research
Integrated Analysis of circRNA- related ceRNA Network Targeting Neuroinflammation in Medial Temporal Lobe Epilepsy
CONCLUSIONS: In summary, our study identified a hub ceRNA network and validated a potential circRNA-miRNA-mRNA axis targeting neuroinflammation. The results of our research may serve as a potential therapeutic target for mTLE.PMID:38402995 | DOI:10.1016/j.brainresbull.2024.110908 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 25, 2024 Category: Neurology Authors: Bingzheng Gong Mian Li Ziru Wang Gulingyue Hao Liang Sun Jingjun Zhang Liangjie Yuan Source Type: research
Aerobic exercise modulates the striatal Erk/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease
CONCLUSION: 4 weeks of aerobic exercise can effectively alleviate the development of L-DOPA-induced dyskinesia and improve motor function in PD mice. The related mechanism may be related to the inhibition of striatal Erk/MAPK signaling pathway overactivation by aerobic exercise, but this change did not occur selectively in D1-MSNs.PMID:38395109 | DOI:10.1016/j.brainresbull.2024.110906 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 23, 2024 Category: Neurology Authors: Fangyuan Zhou Longwei Wei Yinhao Wang Wei Chen Source Type: research
The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis
Brain Res Bull. 2024 Feb 21:110907. doi: 10.1016/j.brainresbull.2024.110907. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is considered an immune-mediated inflammatory disorder that causes cognitive impairments by damaging the hippocampal tissue. Conversely, norepinephrine (NEP) has anti-inflammatory and re-myelinating properties, which improve cognitive impairments. The aim of this study was to assess the neuroprotective effects of NEP on learning and memory disorders in an experimental animal model of MS. Two guide cannulas were bilaterally implanted in the rat hippocampal CA1 regions. After recovery, the animal...
Source: Brain Research Bulletin - February 23, 2024 Category: Neurology Authors: Narjes Taherian Gholamhassan Vaezi Ali Neamati Vida Hojjati Faezeh Ghorbani-Taherdehi Amirhossein Sahebkar Mahmoud Gorji-Valokola Source Type: research
Aerobic exercise modulates the striatal Erk/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease
CONCLUSION: 4 weeks of aerobic exercise can effectively alleviate the development of L-DOPA-induced dyskinesia and improve motor function in PD mice. The related mechanism may be related to the inhibition of striatal Erk/MAPK signaling pathway overactivation by aerobic exercise, but this change did not occur selectively in D1-MSNs.PMID:38395109 | DOI:10.1016/j.brainresbull.2024.110906 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 23, 2024 Category: Neurology Authors: Fangyuan Zhou Longwei Wei Yinhao Wang Wei Chen Source Type: research
The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis
Brain Res Bull. 2024 Feb 21:110907. doi: 10.1016/j.brainresbull.2024.110907. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is considered an immune-mediated inflammatory disorder that causes cognitive impairments by damaging the hippocampal tissue. Conversely, norepinephrine (NEP) has anti-inflammatory and re-myelinating properties, which improve cognitive impairments. The aim of this study was to assess the neuroprotective effects of NEP on learning and memory disorders in an experimental animal model of MS. Two guide cannulas were bilaterally implanted in the rat hippocampal CA1 regions. After recovery, the animal...
Source: Brain Research Bulletin - February 23, 2024 Category: Neurology Authors: Narjes Taherian Gholamhassan Vaezi Ali Neamati Vida Hojjati Faezeh Ghorbani-Taherdehi Amirhossein Sahebkar Mahmoud Gorji-Valokola Source Type: research
The role of T-lymphocytes in central nervous system diseases
Brain Res Bull. 2024 Feb 20;209:110904. doi: 10.1016/j.brainresbull.2024.110904. Online ahead of print.ABSTRACTThe central nervous system (CNS) has been considered an immunologically privileged site. In the past few decades, research on inflammation in CNS diseases has mostly focused on microglia, innate immune cells that respond rapidly to injury and infection to maintain CNS homeostasis. Discoveries of lymphatic vessels within the dura mater and peripheral immune cells in the meningeal layer indicate that the peripheral immune system can monitor and intervene in the CNS. This review summarizes recent advances in the invo...
Source: Brain Research Bulletin - February 22, 2024 Category: Neurology Authors: Jianing Shen Ning Bian Lu Zhao Jingkuan Wei Source Type: research
