Acute bone damage through liver-bone axis induced by thioacetamide in rats
Thioacetamide (TAA) is used in various fields, such as synthetic drugs, organic chemical synthesis, and materials chemistry. TAA is mainly used to establish animal liver injury models and other organ damage mo... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 7, 2022 Category: Drugs & Pharmacology Authors: Xiaoli Jin, Yang Li, Jianghua Li, Linyan Cheng, Yetao Yao, Hao Shen, Bili Wang, Jun Ren, Hang Ying and Jian Xu Tags: Research article Source Type: research
Correction to: Evaluation of the importance of mixing during preparation of antibiotic infusions
(Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 28, 2022 Category: Drugs & Pharmacology Authors: Ina Barzel, Janique Gabri ëlle Jessurun, Soma Bahmany, Paul Hugo Marie van der Kuy, Birgit Catharina Peter Koch and Nicole Geertruida Maria Hunfeld Tags: Correction Source Type: research
Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh
The use of chemical pesticides in developing countries like Bangladesh and their impacts on human health and food security is a global concern. Bangladesh is an agricultural dependent country for the growing p... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 28, 2022 Category: Drugs & Pharmacology Authors: Amir Hossan Shaikat, Shahneaz Ali Khan, Mohammed Ashif Imtiaz, Md Ridoan Pasha, Jabin Sultana, Arfanul Saif and Mohammad Rashedul Alam Tags: Research Source Type: research
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1 β
The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are related to lung cancer, and benzo(a) pyrene is a representative of PAHs.... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 26, 2022 Category: Drugs & Pharmacology Authors: Mengdi Zhang, Yuxia Hu, Fan Yang, Jingwen Zhang, Jianxin Zhang, Wanjia Yu, Minjie Wang, Xiaoli Lv, Jun Li, Tuya Bai and Fuhou Chang Tags: Research Source Type: research
TCDD exposure alters fecal IgA concentrations in male and female mice
Activation of the aryl hydrocarbon receptor (AhR) can alter diurnal rhythms including those for innate lymphoid cell numbers, cytokine and hormone levels, and feeding behaviors. Because immune responses and an... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 21, 2022 Category: Drugs & Pharmacology Authors: Christine L. Foxx, Madeline R. Nagy, Aspen E. King, Dreycey Albin and Gregory K. DeKrey Tags: Research Source Type: research
ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF- κB pathway
Inflammation plays a major role in the pulmonary artery hypertension (PAH) and the acute lung injury (ALI) diseases. The common feature of these complications is the dysfunction of pulmonary microvascular endo... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 15, 2022 Category: Drugs & Pharmacology Authors: Huanlong Liu, Zhenhua Pan, Xindi Ma, Junru Cui, Juan Gao, Qingfeng Miao, Zhongning Zhu, Xueyan Chen and Suwen Su Tags: Research Source Type: research
Evaluation of the importance of mixing during preparation of antibiotic infusions
The mixing step after medication addition to the infusion bag is frequently omitted during the preparation of drug infusions. However, the importance of mixing when preparing antibiotic infusions is still unkn... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 8, 2022 Category: Drugs & Pharmacology Authors: Ina Barzel, Janique Gabri ëlle Jessurun, Soma Bahmany, Paul Hugo Marie van der Kuy, Birgit Catharina Peter Koch and Nicole Geertruida Maria Hunfeld Tags: Research article Source Type: research
TGF- β induced reprogramming and drug resistance in triple-negative breast cells
The development of drug resistance remains to be a major cause of therapeutic failure in breast cancer patients. How drug-sensitive cells first evade drug inhibition to proliferate remains to be fully investig... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 8, 2022 Category: Drugs & Pharmacology Authors: Guoyu Wu and Yuchao Li Tags: Research Source Type: research
Wnt-induced secreted proteins-1 play an important role in paraquat-induced pulmonary fibrosis
The objective of this article is to observe the expression of Wnt-induced secreted proteins-1 (WISP1) in paraquat (PQ)-induced pulmonary fibrosis (PF) to explore the role of WISP1. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 6, 2022 Category: Drugs & Pharmacology Authors: Lanrong Li, Shengnan Lv, Xin Li and Jingyan Liu Tags: Research Source Type: research
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells
Hydroquinone (HQ) is a phenolic metabolite of benzene with a potential risk for hematological disorders and hematotoxicity in humans. In the present study, an integrative analysis of microRNA (miRNA) and mRNA ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 2, 2022 Category: Drugs & Pharmacology Authors: Chun-Hong Yu, Shui-Qing Yang, Lei Li, Yu Xin, Fang Zhang, Xiao-Fan Liu and Zong-Chun Yi Tags: Research Source Type: research
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells
Lung injury elicited by respiratory exposure to humidifier disinfectants (HDs) is known as HD-associated lung injury (HDLI). Current elucidation of the molecular mechanisms related to HDLI is mostly restricted... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 30, 2022 Category: Drugs & Pharmacology Authors: Hong Lee, Sang Hoon Jeong, Hyejin Lee, Cherry Kim, Yoon Jeong Nam, Ja Young Kang, Myeong Ok Song, Jin Young Choi, Jaeyoung Kim, Eun-Kee Park, Yong-Wook Baek and Ju-Han Lee Tags: Research Source Type: research
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway
Propofol and dexmedetomidine (DEX) are widely used in general anesthesia, and exert toxic and protective effects on hippocampal neurons, respectively. The study sought to investigate the molecular mechanisms o... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 25, 2022 Category: Drugs & Pharmacology Authors: Zong Chen, Yong Ding, Ying Zeng, Xue-Ping Zhang and Jian-Yan Chen Tags: Research Source Type: research
Is high sensitive-troponin I a reliable biomarker for cardiac injury in methadone toxicity? A prospective cross-sectional study
Methadone is a synthetic opioid mostly used for detoxification therapy, as its use increases; the possibility for methadone-induced cardiotoxicity may rise. The aim of this study was to determine the associati... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 23, 2022 Category: Drugs & Pharmacology Authors: Hasan Shemirani, Masoumeh Sadeghi, Azadeh Davoudian Dehkordi and Farzad Gheshlaghi Tags: Research Source Type: research
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling
Arsenic, existing ubiquitously in soil, drinking water, or food, is well known to be an environmental pollutants concerned by European Food Safety Authority. Lentinan, a beta-1,6;1,3-glucan extracts from Lentinus... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 22, 2022 Category: Drugs & Pharmacology Authors: Yuan Yang, Shuang Song, Yuanyuan Nie, Rong Chen and Peng Chen Tags: Research Source Type: research
Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity
This study a... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 28, 2022 Category: Drugs & Pharmacology Authors: Maihaba Muhetaer, Mei Yang, Rongxiang Xia, Yuanyan Lai and Jun Wu Tags: Research Source Type: research
