Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol ®:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects
Ezetimibe is a new class of antihyperlipidemic agent indicated for the prevention of atherosclerosis disease and for the treatment of hypercholesterolemia. Information on the pharmacokinetic profiles of ezetim... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 3, 2023 Category: Drugs & Pharmacology Authors: Feifei Sun, Yanping Liu, Ting Li, Pingping Lin, Xin Jiang, Xin Li, Chenjing Wang, Xiaomeng Gao, Yaping Ma, Yao Fu and Yu Cao Tags: Research article Source Type: research
Glycyrrhetinic acid protects against Multidrug-resistant Acinetobacter baumannii-induced lung epithelial cells injury by regulating inflammation and oxidative stress
Glycyrrhetinic acid (GA) is a bio-effective component of Licorice. The GA is a monomer and the ingredient is an Oleanane-type pentacyclic triterpenes that has been used as a remedy for years. Due to the abuse ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 30, 2023 Category: Drugs & Pharmacology Authors: Piaoyi Guo, Liang Jin, Huifen Zhou, Yida Bao, Jiehong Yang, Jing Chen, Yu He, Daojun Yu and Haitong Wan Tags: Research Source Type: research
Publisher Correction to: Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm
(Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 30, 2023 Category: Drugs & Pharmacology Authors: Ze Zhang, Xiue Mu and Xiaohui Zhou Tags: Correction Source Type: research
Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil
Regulations have broadened to allow moderate sedation administration for gastrointestinal endoscopy by non-anesthesia personnel. The line between moderate and deep sedation is ambiguous. Deep sedation offers p... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 16, 2023 Category: Drugs & Pharmacology Authors: Jing-Yang Liou, I-Ting Kuo, Weng-Kuei Chang, Chien-Kun Ting and Mei-Yung Tsou Tags: Research Source Type: research
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol
The literature recommends against the use of fondaparinux in patients with kidney failure and dialysis as it may, with repeated dosing, accumulate and put patients at risk of bleeding. The management of patien... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 13, 2023 Category: Drugs & Pharmacology Authors: Dania Ghaziri, Hassan Dehaini, Mayyas Msheik, Marwan Bahmad, Maya Zorkot and George Abi Saad Tags: Research Source Type: research
Cardioprotective effect of crude polysaccharide fermented by Trametes Sanguinea Lyoyd on doxorubicin-induced myocardial injury mice
Doxorubicin (DOX) is a broad-spectrum anti-tumor drug, but its clinical application is greatly limited because of the cardiotoxicity. Thus, exploration of effective therapies against DOX-induced cardiotoxicity... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 10, 2023 Category: Drugs & Pharmacology Authors: Chenjun Shen, Bo Yang, Lili Huang, Yueru Chen, Huajun Zhao and Zhihui Zhu Tags: Research Source Type: research
Hydrogen sulfide attenuates lung injury instigated by Bisphenol-A via suppressing inflammation and oxidative stress
The xenoestrogen bisphenol A (BPA), a commonly used industrial chemical, has been linked to endocrine disruption. The point of the study was to consider the effects of chronic BPA exposure on the respiratory s... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 30, 2022 Category: Drugs & Pharmacology Authors: Omayma A. R. Abo-Zaid, Fatma S. M. Moawed, Hend A. Hassan and Enas M. Moustafa Tags: Research Source Type: research
Prescribing pattern of anti-hypertensive medications among hypertensive outpatients at selected hospitals of South Gondar Zone, Amhara, Ethiopia: a hospital based cross sectional study
Irrational prescription has a lion share for uncontrolled blood pressure. There is no study assessing prescription pattern among hypertensive patients at the study sites. Therefore, the objective of the curren... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 30, 2022 Category: Drugs & Pharmacology Authors: Taklo Simeneh Yazie, Yohannes Shumet Yimer, Abebe Muche Belete and Getaye Tessema Desta Tags: Research Source Type: research
Toxico-clinical study of patients poisoned with household products; a two-year cross-sectional study
Several studies worldwide have investigated household product poisoning. We conducted a toxico-clinical study on the two-year prevalence of poisoning with household products. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 29, 2022 Category: Drugs & Pharmacology Authors: Nastaran Eizadi-Mood, Sahar Sadat Lalehzar, Sara Niknam, Razieh Mahvari, Parisa Mirmoghtadaee and Rokhsareh Meamar Tags: Research Source Type: research
Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells
Among the food additives used in the food industry, food dyes are considered the most toxic. For instance, tartrazine (TRZ) is a food colorant commercially available with conflicting data regarding its cytotox... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 23, 2022 Category: Drugs & Pharmacology Authors: Jailson Rodrigues dos Santos, Larissa de Sousa Soares, Bruno Moreira Soares, Marlene de Gomes Farias, Victor Alves de Oliveira, Natan Ant ônio Batista de Sousa, Helber Alves Negreiros, Felipe Cavalcanti Carneiro da Silva, Ana Paula Peron, Ana Carolina La Tags: Research Source Type: research
Association between anticholinergic activity and xerostomia and/ or xerophthalmia in the elderly: systematic review
The aim of this work was to investigate the association between anticholinergic burden or anticholinergic drug use and xerostomia and/or xerophtalmia in elderly through a systematic review of the published lit... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 21, 2022 Category: Drugs & Pharmacology Authors: E. Prado-Mel, P. Ciudad-Guti érrez, H. Rodríguez-Ramallo, S. Sánchez-Fidalgo, B. Santos-Ramos and A. M. Villalba-Moreno Tags: Research Source Type: research
Radotinib attenuates TGF β -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing
Tyrosine kinase (TK) plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis. Here, we aimed to investigate whether radotinib (Rb) could inhibit pulmonary fibrosis by inhibiting TK in vitro a... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 15, 2022 Category: Drugs & Pharmacology Authors: Suji Baek, Seung Hae Kwon, Joo Yeong Jeon, Gong Yeal Lee, Hyun Soo Ju, Hyo Jung Yun, Dae Jin Cho, Kang Pa Lee and Myung Hee Nam Tags: Research Source Type: research
Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression
Patients with cancer rely on morphine for analgesia, while studies have indicated morphine can induce immunosuppression in cancer. Therefore, investigating the immunosuppressive roles and molecular mechanism o... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 7, 2022 Category: Drugs & Pharmacology Authors: Qichao Wang, Zhenfu Liu, Shuhong Tang and Zhen Wu Tags: Research Source Type: research
Potential antiviral peptides targeting the SARS-CoV-2 spike protein
The coronavirus disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became an international pandemic and created a public health crisis. The binding of the viral Spike ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 2, 2022 Category: Drugs & Pharmacology Authors: Ibrahim Khater and Aaya Nassar Tags: Research Source Type: research
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
Intervertebral disc degeneration results from a variety of etiologies, including inflammation and aging. Degenerated intervertebral discs feature down-regulated extracellular matrix synthesis, resulting in los... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 1, 2022 Category: Drugs & Pharmacology Authors: Weisin Chen, Miersalijiang Yasen, Hanquan Wang, Chenyang Zhuang, Zixiang Wang, Shunyi Lu, Libo Jiang and Hong Lin Tags: Research Source Type: research
