Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells
Hormonal receptor positive (HR+) breast cancer is the most commonly diagnosed molecular subtype of breast cancer; which showed good response to doxorubicin (DOX)-based chemotherapy. Eugenol (EUG) and astaxanth... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 28, 2021 Category: Drugs & Pharmacology Authors: Mariam A. Fouad, Mohamed M. Sayed-Ahmed, Etimad A. Huwait, Hafez F. Hafez and Abdel-Moneim M. Osman Tags: Research article Source Type: research
Safety of natural anthraquinone emodin: an assessment in mice
Emodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surroun... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 28, 2021 Category: Drugs & Pharmacology Authors: Alexander T. Sougiannis, Reilly T. Enos, Brandon N. VanderVeen, Kandy T. Velazquez, Brittany Kelly, Sierra McDonald, William Cotham, Ioulia Chatzistamou, Mitzi Nagarkatti, Daping Fan and E. Angela Murphy Tags: Research article Source Type: research
Improved effect of a mitochondria-targeted antioxidant on hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells
Oxidative damage to retinal pigment epithelial (RPE) cells contributes to the development of age-related macular degeneration, which is among the leading causes of visual loss in elderly people. In the present... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 20, 2021 Category: Drugs & Pharmacology Authors: Myung Hee Kim, Do-Hun Kim, Su Geun Yang and Dae Yu Kim Tags: Research article Source Type: research
Depressive effectiveness of vigabatrin ( γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells
Vigabatrin (VGB) is an approved non-traditional antiepileptic drug that has been revealed to have potential for treating brain tumors; however, its effect on ionic channels in glioma cells remains largely uncl... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 13, 2021 Category: Drugs & Pharmacology Authors: Te-Yu Hung, Huai-Ying Ingrid Huang, Sheng-Nan Wu and Chin-Wei Huang Tags: Research article Source Type: research
Detecting medication errors associated with the use of beta-lactams in the Russian Pharmacovigilance database
Comprehensive analysis of all available data in spontaneous reports (SRs) can reveal previously unidentified medication errors (MEs). (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 8, 2021 Category: Drugs & Pharmacology Authors: Anna V. Kuzmina, Irina L. Asetskaya, Sergey K. Zyryanov and Vitaliy A. Polivanov Tags: Research article Source Type: research
Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale
Considering the limited generalizability of previous anticholinergic burden scales, the Korean Anticholinergic Burden Scale (KABS) as a scale specific to the Korean population was developed. We aimed to valida... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 7, 2021 Category: Drugs & Pharmacology Authors: Sunghee Hwang, Jee Eun Chung, Kwanghee Jun, Young-Mi Ah, Kwang-Il Kim and Ju-Yeun Lee Tags: Research article Source Type: research
Extended adverse effects of cyclophosphamide on mouse ovarian function
Most patients with cancer undergo multiple administrations of anticancer drugs during treatment, resulting in chronic impairment of their reproductive health. As improved treatment options increase cancer surv... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 7, 2021 Category: Drugs & Pharmacology Authors: Jihyun Kim and Sooseong You Tags: Research article Source Type: research
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test
Acetaminophen (APAP) induced hepatotoxicity is a clinically important problem. Up to now, interventive therapy with n-acetylcysteine (NAC) has been considered as a gold-standard treatment for APAP overdose. Ho... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 7, 2021 Category: Drugs & Pharmacology Authors: Samaneh Nakhaee, Mohammad Dastjerdi, Hesam Roumi, Omid Mehrpour and Khadijeh Farrokhfall Tags: Research article Source Type: research
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma
The development of novel and effective drugs for targeted human hepatocellular carcinoma still remains a great challenge. The alkaloid nitidine chloride (NC), a component of a traditional Chinese medicine, has... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 6, 2021 Category: Drugs & Pharmacology Authors: Danni Li, Shaogang Liu, Jiahao Zhu, Liqun Shen, Qi ying Zhang and Hua Zhu Tags: Research article Source Type: research
Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product
A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application. The present research reports on a Phase 1 study to (i) d... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 14, 2020 Category: Drugs & Pharmacology Authors: Beth R. Cameron, Ludvina Ferreira and I. David MacDonald Tags: Research article Source Type: research
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study
Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adul... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 10, 2020 Category: Drugs & Pharmacology Authors: Seong-Dae Woo, Jiwon Yoon, Go-Eun Doo, Youjin Park, Youngsoo Lee, So-Hee Lee, Young-Hee Lee and Young-Min Ye Tags: Research article Source Type: research
Efficacy and safety of bempedoic acid alone or combining with other lipid-lowering therapies in hypercholesterolemic patients: a meta-analysis of randomized controlled trials
Bempedoic acid is a new drug that reduces cholesterol synthesis via inhibiting ATP citrate lyase. It remains unclear whether the combination of bempedoic acid and other lipid-lowering drugs is better than thes... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 4, 2020 Category: Drugs & Pharmacology Authors: Xiang Zhao, Xubiao Ma, Xing Luo, Zhihua Shi, Ziwen Deng, Yuanxiang Jin, Zhipeng Xiao, Liming Tan, Pingfang Liu, Shilong Jiang, Yuanglu Shu, Bing Tang and Chengfeng Qiu Tags: Research article Source Type: research
Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine
The present study was designed to investigate the protective effects and mechanisms of carnosine on lipopolysaccharide (LPS)-induced injury in Caenorhabditis elegans. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 3, 2020 Category: Drugs & Pharmacology Authors: Jing Ma, Xiaoyuan Xu, Ranran Wang, Haijing Yan, Huijuan Yao, Hongmei Zhang, Shaowei Jiang and Ajing Xu Tags: Research article Source Type: research
Nebivolol combined with tetrahydrobiopterin affects diastolic function in spontaneously hypertensive rats via the nitric oxide/cyclic guanosine monophosphate signalling pathway
Hypertension is the the primary cause of diastolic heart failure. Oxidative stress plays an important role in cardiac diastolic dysfunction caused by hypertension. The occurrence of oxidative stress is related... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 2, 2020 Category: Drugs & Pharmacology Authors: Xiaoli Guan, Xiaoying Guan, Changhong Lu, Bo Shang, Yuan Zhao, Ying Meng and Zhengyi Zhang Tags: Research article Source Type: research
Presentations of tetramethylammonium hydroxide dermal exposure and the valuable potential of diphoterine solution in decontamination: a retrospective observational study
Tetramethylammonium hydroxide (TMAH) is a quaternary ammonium compound that is both a base corrosive and a cholinergic agonist, and it is widely used in the photoelectric and semiconductor industries. It cause... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 30, 2020 Category: Drugs & Pharmacology Authors: Chih-Kang Huang, Alan H. Hall, Ming-Ling Wu, Chen-Chang Yang, Dong-Zong Hung, Yan-Chiao Mao and Jou-Fang Deng Tags: Research article Source Type: research
