Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis
Obsessive-compulsive disorder (OCD) is among the most disabling neuropsychiatric conditions characterized by the presence of repetitive intrusive thoughts, impulses, or images (obsessions) and/or ritualized me... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 4, 2021 Category: Drugs & Pharmacology Authors: Fatemeh Hadi, Shayan Kashefinejad, Leila Kamalzadeh, Saba Hoobehfekr and Mohammadreza Shalbafan Tags: Research Source Type: research
Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer
Ovarian cancer is the world ’s dreaded disease and its prevalence is expanding globally. The study of integrated molecular networks is crucial for the basic mechanism of cancer cells and their progression. Duri... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 2, 2021 Category: Drugs & Pharmacology Authors: Suchitra Maheswari Ajjarapu, Apoorv Tiwari, Gohar Taj, Dev Bukhsh Singh, Sakshi Singh and Sundip Kumar Tags: Research Source Type: research
Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model
Mycophenolic acid (MPA) is the most widely used immunosuppressive drug in transplantation and for autoimmune diseases. Unfortunately, more than 30% of patients experience a typical gastrointestinal adverse eff... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 28, 2021 Category: Drugs & Pharmacology Authors: Manon Jardou, Quentin Provost, Clarisse Brossier, Émilie Pinault, François-Ludovic Sauvage and Roland Lawson Tags: Research Source Type: research
WHO/INRUD Core drug use indicators and commonly prescribed medicines: a National Survey from Sri Lanka
Identification of internationally comparable indicators of medicines use are important for a country to implement strategies and regulations to improve usage of medicines. Sri Lanka established a new National ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 28, 2021 Category: Drugs & Pharmacology Authors: P. Galappatthy, P. Ranasinghe, C. K. Liyanage, M. S. Wijayabandara, S. Mythily and R. L. Jayakody Tags: Research Source Type: research
Identification and solution of drug-related problems in the neurology unit of a tertiary hospital in China
This study aimed to determine the prevalence... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 26, 2021 Category: Drugs & Pharmacology Authors: Pengpeng Liu, Guangyao Li, Mei Han and Chao Zhang Tags: Research Source Type: research
Therapeutic activity of sarpogrelate and dopamine D2 receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes
Dopamine D2 receptor agonists, bromocriptine and cabergoline, are notable medications in the treatment of Parkinsonism, hyperprolactinemia, and hyperglycemia. An affiliation was found between the initiation of my... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 26, 2021 Category: Drugs & Pharmacology Authors: Mohammed Ahmed Fouad Shalaby, Hekma A. Abd El Latif, Mohamed El Yamani, May Ahmed Galal, Sherifa Kamal, Ikhlas Sindi and Raneem Masaood Tags: Research article Source Type: research
High dose and hepatobiliary dysfunction are associated with hand-foot syndrome in patients with lymphoma using pegylated liposomal doxorubicin: a retrospective study
In clinical practice, the risk factors for pegylated liposomal doxorubicin-related hand-foot syndrome remain unclear. The purpose of this study was to determine the risk factors associated with hand-foot syndr... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 25, 2021 Category: Drugs & Pharmacology Authors: Yanfang Zhao, Wenjia Su, Guohua Liang, Xiaoyu Shan, Weiwei Ma, Dabei Tang, Liru Li, Xingjian Niu, Shu Zhao, Qingyuan Zhang and Wenhui Zhao Tags: Research Source Type: research
Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells
Cell pyroptosis has been characterized by cell swelling and pro-inflammatory factors release to aggravate inflammatory reaction., such as interlukin-1 beta (IL-1 β) and interlukin18 (IL-18). However, the functi... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 22, 2021 Category: Drugs & Pharmacology Authors: Jin Huang, Pingsheng Fan, Miao Liu, Chengtao Weng, Gaofei Fan, Tengyue Zhang, Xiaohong Duan, Yang Wu, Lili Tang, Guohong Yang and Yabei Liu Tags: Research Source Type: research
Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19
The emergence and rapid spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in thelate 2019 has caused a devastating global pandemic of the severe pneumonia-like disease coronavirus disease ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 21, 2021 Category: Drugs & Pharmacology Authors: Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D. Lorne J. Tyrrell and Jack A. Tuszynski Tags: Research Source Type: research
Body fluids from the rat exposed to chlorpyrifos induce cytotoxicity against the corresponding tissue −derived cells in vitro
This study aims to establish an in vitro monitoring approach to evaluate the pesticide exposures. We studied the in vitro cytotoxicity of three different body fluids of rats to the respective corresponding tissue... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 20, 2021 Category: Drugs & Pharmacology Authors: Yu-Jie Liang, Ding-Xin Long, Ming-Yuan Xu, Hui-Ping Wang, Ying-Jian Sun and Yi-Jun Wu Tags: Research Source Type: research
The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication
Tramadol is a widely used synthetic opioid for moderate to severe pain. Some studies have shown that tramadol can increase oxidative stress in different tissues of the body. Quercetin is also a substance with ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 19, 2021 Category: Drugs & Pharmacology Authors: Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Mohsen Foadoddini, Masoumeh Askari and Omid Mehrpour Tags: Research Source Type: research
COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia
Coronavirus Disease (COVID-19) caused by Novel Coronavirus named as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared Pandemic by The World Health Organization (WHO) and a Public Health... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Supangat, Elly Nurus Sakinah, Muhammad Yuda Nugraha, Tegar Syaiful Qodar, Bagus Wahyu Mulyono and Achmad Ilham Tohari Tags: Research Source Type: research
Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs
Pharmacokinetics (PK) is the process of absorption, distribution, metabolism and elimination (ADME) of drugs. Some drugs undergo zero-order kinetics (ethyl alcohol), first order kinetics (piroxicam) and mixed ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 11, 2021 Category: Drugs & Pharmacology Authors: Saganuwan Alhaji Saganuwan Tags: Technical advance Source Type: research
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs
Adverse drug reactions (ADRs) in the pediatric population may differ in types and frequencies compared to other populations. Respective studies analyzing ADR reports referring to children have already been per... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 7, 2021 Category: Drugs & Pharmacology Authors: Diana Dubrall, Sarah Leitzen, Irmgard Toni, Julia Stingl, M. Schulz, Matthias Schmid, Antje Neubert and Bernhardt Sachs Tags: Research article Source Type: research
Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway
Sunitinib is known to cause cardiotoxicity in clinical settings. However, among sunitinib-treated patients experiencing adverse cardiac events, decreased cardiac function was reportedly reversible in> 50% of ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Toshikatsu Matsui and Tadahiro Shinozawa Tags: Research Source Type: research
