In diabetic male Wistar rats, quercetin-conjugated superparamagnetic iron oxide nanoparticles have an effect on the SIRT1/p66Shc-mediated pathway related to cognitive impairment
Quercetin (QC) possesses a variety of health-promoting effects in pure and in conjugation with nanoparticles. Since the mRNA-SIRT1/p66Shc pathway and microRNAs (miRNAs) are implicated in the oxidative process,... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 21, 2023 Category: Drugs & Pharmacology Authors: Mahnaz Karami Chamgordani, Akram Bardestani, Shiva Ebrahimpour and Abolghasem Esmaeili Tags: Research Source Type: research
Addition of progesterone to feminizing gender-affirming hormone therapy in transgender individuals for breast development: a randomized controlled trial
Feminizing gender-affirming hormone therapy (GAHT) for transgender individuals traditionally includes estradiol and androgen deprivation. Research has demonstrated that breast size as a result of GAHT in trans... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Benthe A.M. Dijkman, Danithsia Helder, Lidewij S. Boogers, Noor C. Gieles, Jason O. van Heesewijk, Sjoerd te Slaa, Niels P.T.J. Liberton, Chantal M. Wiepjes, Christel J.M. de Blok, Martin den Heijer and Koen M.A. Dreijerink Tags: Study Protocol Source Type: research
Effectiveness and safety of different doses of febuxostat compared with allopurinol in the treatment of hyperuricemia: a meta-analysis of randomized controlled trials
The prevalence of hyperuricemia has increased steadily with the continuous improvement of living standards. Some studies have reported the clinical effectiveness and safety of different doses of febuxostat in ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 14, 2023 Category: Drugs & Pharmacology Authors: Hong Xie, Nan Hu, Ting Pan, Jun-Cai Wu, Miao Yu and Deng-Chao Wang Tags: Research Source Type: research
Long-term survival in venous thromboembolic disease: rivaroxaban vs. warfarin – propensity score matching study
Venous thromboembolic disease (VTE) is characterized by obstruction of venous blood flow by a thrombus. Survival data, frequency of disease recurrence, and bleeding rate in patients on anticoagulant therapy wi... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 13, 2023 Category: Drugs & Pharmacology Authors: Estefan Ramos-Isaza, Eduardo Tuta-Quintero, Alirio Bastidas-Goyes, Diana Diaz-Quijano, Carolina Aponte-Murcia, Julian Espitia-Angel, Daniel Pinto-Beltran, Johan Rinc ón-Hernández, Juan Sánchez-Cuellar, Jesus Pérez-Bueno and Luis F. Giraldo-Cadavid Tags: Research Source Type: research
Host microbiome associated low intestinal acetate correlates with progressive NLRP3-dependent hepatic-immunotoxicity in early life microcystin-LR exposure
Microcystins (MCs), potent hepatotoxins pose a significant health risk to humans, particularly children, who are more vulnerable due to higher water intake and increased exposure during recreational activities. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 13, 2023 Category: Drugs & Pharmacology Authors: Madhura More, Somdatta Chatterjee, Punnag Saha, Dipro Bose, Ayushi Trivedi, Subhajit Roy and Saurabh Chatterjee Tags: Research Source Type: research
Levocetrizine attenuates cyclophosphamide-induced lung injury through inhibition of TNF- α, IL-1β, TGF-β and MMP-9
Cyclophosphamide (CP) is an antineoplastic drug commonly used worldwide. Despite its spread, it causes fatal organ toxicity. Lung toxicity is a serious side effect of CP. Actually, in the past three years the ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dalia H. El-Kashef and Mona Abdel Rahim Tags: Research Source Type: research
Comparison of the efficacy of anti-diabetic medications as add-on to metformin in type 2 diabetes mellitus from a real-world database
Metformin is recommended as a first-line drug in the guidelines of the treatment for type 2 diabetes mellitus. However, high-quality evidence from clinical trials directly comparing the degree of hypoglycemic ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 9, 2023 Category: Drugs & Pharmacology Authors: Ryosuke Ono, Chika Ogami, Chihiro Hasegawa, Hideto To, Yoshiaki Matsumoto and Yasuhiro Tsuji Tags: Research Source Type: research
Dolutegravir-induced growth and lifespan effects in Caenorhabditis elegans
Integrase strand transfer inhibitor (INSTIs)-based combination antiretroviral treatment in people living with HIV (PLWH) has been reportedly correlated with several adverse effects, such as weight gain, fetal ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 7, 2023 Category: Drugs & Pharmacology Authors: Shin-Huei Kuo, Wen-Li Hsu, Ching-Ying Wu, Yu-Chang Lai and Tun-Chieh Chen Tags: Research Source Type: research
Antibiotics and antibiotic-associated diarrhea: a real-world disproportionality study of the FDA adverse event reporting system from 2004 to 2022
Our study aimed to assess the risk signals of antibiotic-associated diarrhea (AAD) caused by various antibiotics using real-world data and provide references for safe clinical applications. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 4, 2023 Category: Drugs & Pharmacology Authors: Haining Huang, Lanfang Li, Mingli Wu, Zhen Liu, Yanyan Zhao, Jing Peng, Xiaolei Ren and Shuai Chen Tags: Research Source Type: research
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis
The main purpose was to evaluate the efficacy and tolerability of different medications used to treat bulimia nervosa (BN). (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 2, 2023 Category: Drugs & Pharmacology Authors: Sijie Yu, Yuhan Zhang, Chongkai Shen and Fei Shao Tags: Research Source Type: research
Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns
Nebulizers are commonly used to treat respiratory diseases, which are a major cause of morbidity and mortality. While inhalation therapy with antibodies has been evaluated in preclinical studies and clinical t... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: Soon Woo Hong, Kyung Hwa Chang, Chang Jae Woo, Ho Chul Kim, Bong Seop Kwak, Bong Joo Park and Ki Chang Nam Tags: Research Source Type: research
Efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a meta-analysis
To evaluate the efficacy and safety of thrombopoietin receptor agonists (TPO-RAs) in solid tumors with chemotherapy-induced thrombocytopenia (CIT). (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: Wen Chen, Yubingxue Liu, Luchun Li and Xianghua Zeng Tags: Review Source Type: research
In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus ™ software
The prediction of intestinal absorption of various drugs based on computer simulations has been a reality. However, in vivo pharmacokinetic simulations and virtual bioequivalence evaluation based on GastroPlus... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 28, 2023 Category: Drugs & Pharmacology Authors: Lu Wang, Jinliang Chen, Wenjun Chen, Zourong Ruan, Honggang Lou, Dandan Yang and Bo Jiang Tags: Research Source Type: research
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats
Imidacloprid is a neonicotinoid insecticide belonging to the chloronicotinyl nitroguanidine chemical family. Toxicity of IMD for mammals in scientific studies has shown high mutagenic, immunotoxic, teratogenic... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 27, 2023 Category: Drugs & Pharmacology Authors: Amina Sardar, Mehwish David, Sarwat Jahan, Tayyaba Afsar, Aneela Ahmad, Asad Ullah, Ali Almajwal, Huma Shafique and Suhail Razak Tags: Research Source Type: research
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
Atherosclerosis is a form of cardiovascular disease that affects the endothelium of the blood vessel. Series of events are involved in the pathophysiology of this disease which includes the breaking down of th... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 25, 2023 Category: Drugs & Pharmacology Authors: Temitope Akinwumi Ajani, Kenechukwu Obikeze, Zandisiwe E. Magwebu, Samuel Egieyeh and Chesa G. Chauke Tags: Research Source Type: research
