Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model
There were limited studies investigating treatments of septic cardiomyopathy (SCM), which is a common complication during sepsis. A septic rat model created by cecal ligation and puncture (CLP) was used to inv... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 4, 2022 Category: Drugs & Pharmacology Authors: Zhaoqing Lu, Di Wu, Zheng Wang, Hanyu Zhang, Yufan Du and Guoxing Wang Tags: Research Source Type: research
Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo
The capsid (CA) subunit of the HIV-1 Gag polyprotein is involved in several steps of the viral cycle, from the assembly of new viral particles to the protection of the viral genome until it enters into the nuc... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 28, 2022 Category: Drugs & Pharmacology Authors: Guzm án Alvarez, Lisa van Pul, Xavier Robert, Zoraima Artía, Ad C. van Nuenen, Mathieu Long, Natalia Sierra, Williams Porcal, Neeltje A. Kootstra and Christophe Guillon Tags: Research Source Type: research
The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor (SMMT)
Breast cancer is one of the most common types of cancer in women worldwide. Anti-apoptotic activity of cancer cells is considered the main reason for drug resistance in BC which reduces the 5-year survival rat... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 20, 2022 Category: Drugs & Pharmacology Authors: Mandana AmeliMojarad, Melika AmeliMojarad and Alireza Pourmahdian Tags: Research Source Type: research
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations
COVID-19 pandemic has claimed millions of lives and devastated the health service system, livelihood, and economy in many countries worldwide. Despite the vaccination programs in many countries, the spread of ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 18, 2022 Category: Drugs & Pharmacology Authors: Kunlakanya Jitobaom, Chompunuch Boonarkart, Suwimon Manopwisedjaroen, Nuntaya Punyadee, Suparerk Borwornpinyo, Arunee Thitithanyanont, Panisadee Avirutnan and Prasert Auewarakul Tags: Research article Source Type: research
Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats
The current study evaluates the free gallic acid (GA) and GA-loaded mesoporous silica nanoparticles (MSNs) antidepressant efficacy in a rat model of depression caused by reserpine. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 15, 2022 Category: Drugs & Pharmacology Authors: Heba M. Fahmy, Eman R. Mohamed, Aida A. Hussein, Yasser A. Khadrawy and Nawal A. Ahmed Tags: Research Source Type: research
Prevalence of potential drug − drug interactions in the cardiothoracic intensive care unit patients in a Chinese tertiary care teaching hospital
With an increasing number of reviews describing clinically significant drug –drug interactions (DDIs), the scope and severity of interactions involving commonly used drugs in cardiothoracic intensive care units... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 14, 2022 Category: Drugs & Pharmacology Authors: Haitao Wang, Haitao Shi, Na Wang, Yan Wang, Li Zhang, Yujie Zhao and Jiao Xie Tags: Research Source Type: research
Exploring the potential of taurolidine in inducing mobilization and detachment of colon cancer cells: a preliminary in-vitro study
Recently, taurolidine has been intensively studied on a variety of in-vitro cancer cell-lines and first data exhibit encouraging antitumoral effects. While the clinical use of taurolidine is considered, some s... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 13, 2022 Category: Drugs & Pharmacology Authors: Agata Mikolajczyk, Veria Khosrawipour, Hien Lau, Shiri Li, Pawel Migdal, Maya Karine Labb é, Wojciech Kielan, Jakub Nicpon, Sven Stieglitz and Tanja Khosrawipour Tags: Research article Source Type: research
Assessment of biosafety and toxicity of hydrophilic gel for implantation in experimental in vitro and in vivo models
The assessment of biosafety of pharmacologically active substances is crucial for determining the feasibility of their medical use. There are controversial issues regarding the use of substances of different o... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 8, 2022 Category: Drugs & Pharmacology Authors: N. Bezdieniezhnykh, A. Lykhova, T. Kozak, T. Zadvornyi, T. Borikun, O. Voronina and N. Lukianova Tags: Research Source Type: research
Developing a desktop application for drug-drug interaction checker ordered for chronic diseases in Ethiopian hospitals pharmacy
Drug-drug interactions are a major cause of morbidity worldwide and are a leading source of treatment inefficacy. They are classified based on their pharmacological action on the body as major, moderate, and m... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 6, 2022 Category: Drugs & Pharmacology Authors: Thamineni Bheema Lingaiah, Yibeltal Andarge Belay and Kokeb Dese Tags: Software Source Type: research
Nalbuphine alleviates inflammation by down-regulating NF- κB in an acute inflammatory visceral pain rat model
Nalbuphine can relieve patients ’ inflammation response after surgery compared to other opioid drugs. However, its molecular mechanism has not been clear. Activation of NF-κB signaling pathway under oxidative s... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 1, 2022 Category: Drugs & Pharmacology Authors: Dijiao Ruan, Yuanyuan Wang, Sisi Li, Chao Zhang, Wenwen Zheng and Cong Yu Tags: Research Source Type: research
Ethacrynic acid is an inhibitor of human factor XIIIa
Ethacrynic acid (EA) is a loop diuretic that is approved orally and parenterally to manage edema-associated diseases. Nevertheless, it was earlier reported that it is also associated with bleeding upon its par... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 1, 2022 Category: Drugs & Pharmacology Authors: Srabani Kar, Kayla Vu, Madhusoodanan Mottamal and Rami A. Al-Horani Tags: Research Source Type: research
The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation
Tamoxifen treatment may induce dysregulation of estrogen homeostasis, leading to the occurrence of related adverse reactions. However, the potential mechanisms are still unclear. The purpose of the present stu... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 31, 2022 Category: Drugs & Pharmacology Authors: Zhixiang Hao, Jiahao Xu, Han Zhao, Wei Zhou, Zhao Liu, Shiqing He, Xiaoxing Yin, Bei Zhang, Zhongjian Wang and Xueyan Zhou Tags: Research Source Type: research
Cardioprotective effects of sodium thiosulfate against doxorubicin-induced cardiotoxicity in male rats
Doxorubicin (DOX) is an effective antitumor agent, but its clinical usage is limited due to adverse cardiotoxic effects. Several compounds have been studied to reduce DOX cardiotoxicity to improve its therapeu... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 25, 2022 Category: Drugs & Pharmacology Authors: Maryam Shekari, Narges Khalilian Gortany, Mina Khalilzadeh, Alireza Abdollahi, Homanaz Ghafari, Ahmad Reza Dehpour and Mahmoud Ghazi-Khansari Tags: Research Source Type: research
Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study
Adverse drug events (ADEs) are an important public health problem with considerable clinical and economic costs. However there are limited studies of ADE incidence in adult inpatients in low-income countries, ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 17, 2022 Category: Drugs & Pharmacology Authors: Teketel Alemu Ersulo, Mengist Awoke Yizengaw and Behailu Terefe Tesfaye Tags: Research Source Type: research
Aspirin versus placebo on estrogen levels in postmenopausal women: a double-blind randomized controlled clinical trial
Estrogen is involved in the pathogenesis of breast and gynecological cancers. Regular use of aspirin reduces estrogen levels. The present study aimed to evaluate the effect of aspirin on estrogen levels in pos... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 17, 2022 Category: Drugs & Pharmacology Authors: Mohammad Bagher Oghazian, Nooshin Shirzad, Mahdi Ahadi, Shalaleh Eivazi Adli, Samaneh Mollazadeh and Mania Radfar Tags: Research Source Type: research
