Complete atrioventricular block due to timolol eye drops: a case report and literature review
Timolol Maleate is a non-selective beta-adrenergic blocker that is commonly used to treat open-angle glaucoma. Despite its topical administration, ophthalmic timolol enters systemic circulation and produces a ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 2, 2019 Category: Drugs & Pharmacology Authors: Zhuoying Wang, Ian Denys, Feng Chen, Lijie Cai, Xuecui Wang, Daniel R. Kapusta, Yongliang Lv and Juan Gao Tags: Case report Source Type: research

Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs
Anti-neoplastic agents are widely used in the treatment of cancer and some non-neoplastic diseases. These drugs have been proved to be carcinogens, teratogens, and mutagens. Concern exists regarding the possib... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 2, 2019 Category: Drugs & Pharmacology Authors: Maral Ramazani, Razieh Pourahmad Jaktaji, Farshad H. Shirazi, Maria Tavakoli-Ardakani, Ahmad Salimi and Jalal Pourahmad Tags: Research article Source Type: research

Sodium valproate induced acute pancreatitis in a bipolar disorder patient: a case report
Sodium valproate is one of the most widely used antiepileptics and mood stabilizers. However, this drug may induce acute pancreatitis. Few cases have been reported so far, mainly on the pediatric patients who ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 29, 2019 Category: Drugs & Pharmacology Authors: Wanli Huang, Xin Ren, Fang Shen and Baoping Xing Tags: Case report Source Type: research

Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials
As a new generation antihistamine, fexofenadine has been widely used in allergic diseases. However, there is still a lack of collective evidence regarding the antihistamine effects and safety profiles of fexof... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 29, 2019 Category: Drugs & Pharmacology Authors: Cheng-zhi Huang, Zhi-hui Jiang, Jian Wang, Yue Luo and Hua Peng Tags: Research article Source Type: research

Real-world efficacy and safety of eribulin in advanced and pretreated HER2-negative breast cancer in a Spanish comprehensive cancer center
Eribulin improves survival in pre-treated HER2-negative advanced breast cancer (ABC). However, limited data exist on co-morbidities and central nervous system (CNS) efficacy. The purpose of this study was to r... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 21, 2019 Category: Drugs & Pharmacology Authors: Milana Bergamino Sirv én, Adela Fernández-Ortega, Agostina Stradella, Idoia Morilla, Catalina Falo, Silvia Vázquez, Roser Castany, Rafael Villanueva, Sabela Recalde, Valentí Navarro Pérez, Miguel Gil-Gil and Sonia Pernas Tags: Research article Source Type: research

Effect of nicotine 6  mg gum on urges to smoke, a randomized clinical trial
Ability to manage urges to smoke is fundamental to maximizing the chances of success in smoking cessation. Previous studies have linked a higher dose of nicotine in nicotine replacement therapy to a higher suc... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 21, 2019 Category: Drugs & Pharmacology Authors: Anna Hansson, Thomas Rasmussen, Roland Perfekt, Elin Hall and Holger Kraiczi Tags: Research article Source Type: research

Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved
This study was designed to investigate the direct effects of dexmedetomidine on cardiot... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 21, 2019 Category: Drugs & Pharmacology Authors: Fangfang Xia, Zhousheng Jin, Tingting Lin, Xixi Cai, Linmin Pan, Shi Wang, Yaoyao Cai and Hongfei Chen Tags: Research article Source Type: research

Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2)
Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of ne... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 15, 2019 Category: Drugs & Pharmacology Authors: Yu-chi Shen, Caroline Arellano-Garcia, Rosa E. Menjivar, Ethan M. Jewett, Wolfgang Dohle, Sofiia Karchugina, Jonathan Chernoff, Barry V. L. Potter and Kate F. Barald Tags: Research article Source Type: research

Colchicine causes prenatal cell toxicity and increases tetraploid risk
Colchicine is a clinical medicine used for relief from gout and familial Mediterranean fever. Because of its toxic effects, intravenous injection of colchicine has been banned, but it is still widely administe... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 13, 2019 Category: Drugs & Pharmacology Authors: Ding Wang, Yingjun Xie, Minyi Yan, Qianying Pan, Yi Liang and Xiaofang Sun Tags: Research article Source Type: research

Relationship between adverse drug reactions to antibacterial agents and the Klebsiella pneumoniae carbapenemase-producing (KPC) Klebsiella pneumoniae outbreak: insight from a pharmacovigilance study
The management of Klebsiella pneumoniae carbapenemase producing (KPC) infections represents a major challenge. Several safety and efficacy concerns are shared by available antibiotics used in KPC infections, lead... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 12, 2019 Category: Drugs & Pharmacology Authors: Milo Gatti, Emanuel Raschi and Fabrizio De Ponti Tags: Research article Source Type: research

A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity
We present a unique case of a s... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 5, 2019 Category: Drugs & Pharmacology Authors: Xiaonian Han and Jinping Wang Tags: Case report Source Type: research

Magnitude and causes of first-line antiretroviral therapy regimen changes among HIV patients in Ethiopia: a systematic review and meta-analysis
Antiretroviral therapy (ART) has markedly decreased the morbidity and mortality due to HIV/AIDS. ART regimen change is a major challenge for the sustainability of human immunodeficiency virus (HIV) treatment p... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 1, 2019 Category: Drugs & Pharmacology Authors: Zerihun Ataro, Birhanu Motbaynor, Fitsum Weldegebreal, Mekonnen Sisay, Tewodros Tesfa, Habtamu Mitiku, Dadi Marami, Zelalem Teklemariam and Zewdneh Shewamene Tags: Research article Source Type: research

Aromatase inhibitors and risk of cardiovascular events in breast cancer patients: a systematic review and meta-analysis
Cardiovascular events (CVEs) was considered as one of the primary cause to reduce the quality of life in breast cancer patients with aromatase inhibitors (AIs) treatment, which has not been sufficiently addres... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 29, 2019 Category: Drugs & Pharmacology Authors: Yang He, Jianhua Zhang, Guofang Shen, Lin Liu, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang and Dongsheng Hong Tags: Research article Source Type: research

Application effect of apatinib in patients with failure of standard treatment for advanced malignant tumours
In recent years, targeted therapy has received widespread attention. Among these therapies, anti-angiogenic targeted drugs have become one of the hotspots of research. Apatinib is a novel oral small molecule a... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 28, 2019 Category: Drugs & Pharmacology Authors: Guohui Liu, Chunbo Wang, Yunlong He and Mingyan E Tags: Research article Source Type: research

Analysis of spontaneous reporting of suspected adverse drug reactions for non-analgesic over-the-counter drugs from 2008 to 2017
The objective of this study was ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 18, 2019 Category: Drugs & Pharmacology Authors: Josipa Bukic, Doris Rusic, Petar Mas, Deni Karabatic, Josko Bozic, Ana Seselja Perisin, Dario Leskur, Darko Krnic, Sinisa Tomic and Darko Modun Tags: Research article Source Type: research

HIF-1 α contributes to Ang II-induced inflammatory cytokine production in podocytes
Studies have indicated that changed expression of hypoxia-inducible factor-1 α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD). As Angiotensin II (An... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 17, 2019 Category: Drugs & Pharmacology Authors: Hao Huang, Yanqin Fan, Zhao Gao, Wei Wang, Ning Shao, Lu Zhang, Yingjie Yang, Weifang Zhu, Zhaowei Chen, Jijia Hu and Guohua Ding Tags: Research article Source Type: research

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
Poncirin is flavanone derivative (isolated from Poncirus trifoliata) with known pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-colitic. The present study aimed to exp... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 11, 2019 Category: Drugs & Pharmacology Authors: Ruqayya Afridi, Ashraf Ullah Khan, Sidra Khalid, Bushra Shal, Hina Rasheed, Muhammad Zia Ullah, Omer Shehzad, Yeong Shik Kim and Salman Khan Tags: Research article Source Type: research

The adipokine vaspin reduces apoptosis in human hepatocellular carcinoma (Hep-3B) cells, associated with lower levels of NO and superoxide anion
Among adipose-derived factors, adipocytokines play roles as hormones and signaling mediators for apoptotic pathway. Among of them, vaspin, regulates the metabolism of adipose tissue itself as an endocrine orga... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 11, 2019 Category: Drugs & Pharmacology Authors: Magdalena Skonieczna, Dorota Hudy, Tomasz Hejmo, Rafal J. Buldak, Ma łgorzata Adamiec and Michal Kukla Tags: Research article Source Type: research

Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis
There are evidences that chlorogenic acid (CGA) has antidepressant effects, however the underlying molecular mechanism has not been well understood. The aim of the study was to explore the neuroprotective effe... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 9, 2019 Category: Drugs & Pharmacology Authors: Xiaowen Shi, Nian Zhou, Jieyi Cheng, Xunlong Shi, Hai Huang, Mingmei Zhou and Haiyan Zhu Tags: Research article Source Type: research

Adverse drug reactions due to opioid analgesic use in New South Wales, Australia: a spatial-temporal analysis
Pharmaceutical opioid analgesic use continues to rise and is associated with potentially preventable harm including hospitalisation for adverse drug reactions (ADRs). Spatial detection of opioid-related ADRs c... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 5, 2019 Category: Drugs & Pharmacology Authors: Wei Du, Shanley Chong, Andrew J. McLachlan, Lan Luo, Nicholas Glasgow and Danijela Gnjidic Tags: Research article Source Type: research

Effect of green tea on the gastrointestinal absorption of amoxicillin in rats
The investigation of food-drug and plant-drug interactions has become increasingly important. In case of antibiotics, it is essential to achieve and maintain a plasma concentration sufficient for the antimicro... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 30, 2019 Category: Drugs & Pharmacology Authors: Tivadar Kiss, Zolt án Timár, Andrea Szabó, Anita Lukács, Viktória Velky, Gábor Oszlánczi, Edina Horváth, István Takács, István Zupkó and Dezső Csupor Tags: Research article Source Type: research

Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways
Apixaban effectively lowers the risk of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation. Systemic exposure to a given apixaban dose depends on multiple clearance pathway... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 29, 2019 Category: Drugs & Pharmacology Authors: Andrea Huppertz, Caspar Grond-Ginsbach, Chris Dumschat, Kathrin I. Foerster, J ürgen Burhenne, Johanna Weiss, David Czock, Jan C. Purrucker, Timolaos Rizos and Walter E. Haefeli Tags: Case report Source Type: research

Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy
Chemotherapy induced peripheral neuropathy (CIPN) has been attributed to chemotherapeutic agents such as cisplatin which adversely affect disease outcome leading to increased cancer related morbidity. The clin... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 28, 2019 Category: Drugs & Pharmacology Authors: Muhammad Shahid, Fazal Subhan, Nisar Ahmad and Robert D. E. Sewell Tags: Research article Source Type: research

Use of long acting injectable aripiprazole before and through pregnancy in bipolar disorder: a case report
We present a clinical case of aripiprazole L... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 28, 2019 Category: Drugs & Pharmacology Authors: Isabel Ballester-Gracia, Miriam P érez-Almarcha, Ana Galvez-Llompart and Miguel Hernandez-Viadel Tags: Case report Source Type: research

Tigecycline-induced sustained severe hypoglycemia: a case report
We describe a case of sustained and severe hypoglycemia in a patient ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 19, 2019 Category: Drugs & Pharmacology Authors: Yixin Chen, Lin Li, Nan Zhang and Hong Li Tags: Case report Source Type: research

Analysis of severe adverse effects following community-based ivermectin treatment in the Democratic Republic of Congo
The progress of mass, community-directed, treatment with ivermectin (CDTI) for onchocerciasis control was disrupted by severe adverse effects (SAE) in the Democratic Republic of Congo (DRC). The study aimed at... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 16, 2019 Category: Drugs & Pharmacology Authors: Jean-Claude Makenga Bof, Daniel Muteba, Paul Mansiangi, F élicien Ilunga-Ilunga and Yves Coppieters Tags: Research article Source Type: research

Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats
MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating di... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 5, 2019 Category: Drugs & Pharmacology Authors: Ibrahim M. Shokry, Connor J. Shields, John J. Callanan, Zhiyuan Ma and Rui Tao Tags: Research article Source Type: research

Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
Cushing ’s syndrome is an endocrine disorder characterized by the overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the mainstays of pharmacological treatment. Unfortunately, they... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 5, 2019 Category: Drugs & Pharmacology Authors: Megan McGrath, Alissa Hofmann and Douglas E. Raines Tags: Research article Source Type: research

Povidone-iodine ear wash and oral cotrimoxazole for chronic suppurative otitis media in Australian aboriginal children: study protocol for factorial design randomised controlled trial
Chronic suppurative otitis media (CSOM) is a significant health issue affecting Aboriginal Australians. Long-term hearing loss can cause communication problems, educational disadvantage, and social isolation. ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 27, 2019 Category: Drugs & Pharmacology Authors: Christine Wigger, Amanda Jane Leach, Jemima Beissbarth, Victor Oguoma, Ruth Lennox, Sandra Nelson, Hemi Patel, Mark Chatfield, Kathy Currie, Harvey Coates, Keith Edwards, Heidi Smith-Vaughan, Kim Hare, Paul Torzillo, Steven Tong and Peter Morris Tags: Study protocol Source Type: research

Relationship between drug application and mortality rate in Chinese older coronary artery disease/chronic heart failure patients with and without low glomerular filtration rate
This analysis was designed to investigate the relationship between drug application and mortality rate in Chinese older coronary artery disease (CAD)/chronic heart failure (CHF) patients with and without low g... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 26, 2019 Category: Drugs & Pharmacology Authors: Shihui Fu, Ping Ping, Ping Ye and Leiming Luo Tags: Research article Source Type: research

Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?
Pneumonia patients are usually hospitalized due to severe nature of the disease or for the management of comorbid illnesses or associated symptoms. Such patients are prescribed with multiple medications which ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 26, 2019 Category: Drugs & Pharmacology Authors: Sidra Noor, Mohammad Ismail and Zahid Ali Tags: Research article Source Type: research

Influence of N-acetyl-L-cysteine against bisphenol a on the maturation of mouse oocytes and embryo development: in vitro study
Bisphenol A (BPA), an endocrine disruptor, is a widely used chemical that has adverse effects on animal development and reproduction. The current research aimed to evaluate the effect of BPA on the in vitro ma... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 22, 2019 Category: Drugs & Pharmacology Authors: Qian Li and Zhenjun Zhao Tags: Research article Source Type: research

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels
KCNH family of potassium channels is responsible for diverse physiological functions ranging from the regulation of neuronal excitability and cardiac contraction to the regulation of cancer progression. KCNH c... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 17, 2019 Category: Drugs & Pharmacology Authors: Ze-Jun Wang, Purushottam B. Tiwari, Aykut Üren and Tinatin I. Brelidze Tags: Research article Source Type: research

Development of a mortality score to assess risk of adverse drug reactions among hospitalized patients with moderate to severe chronic kidney disease
Chronic kidney disease (CKD) is a significant health burden that increases the risk of adverse events. Currently, there is no validated models to predict risk of mortality among CKD patients experienced advers... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 8, 2019 Category: Drugs & Pharmacology Authors: Monica Danial, Mohamed Azmi Hassali, Ong Loke Meng, Yoon Chee Kin and Amer Hayat Khan Tags: Research article Source Type: research

The effects of thiamine pyrophosphate on ethanol induced optic nerve damage
We aimed to determine the protective effects of thiamine pyrophosphate on ethanol induced optic neuropathy in an experimental model. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 5, 2019 Category: Drugs & Pharmacology Authors: Turgay Ucak, Yucel Karakurt, Gamze Tasli, Ferda Keskin Cimen, Erel Icel, Nezahat Kurt, Ibrahim Ahiskali and Halis S üleyman Tags: Research article Source Type: research

Acute versus chronic methotrexate poisoning; a cross-sectional study
Data is limited on comparison of acute and chronic methotrexate (MTX) poisoning. Methotrexate is an anti-folate drug that may be prescribed in some malignant or chronic inflammatory conditions. The aim of the ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 3, 2019 Category: Drugs & Pharmacology Authors: Arman Ahmadzadeh, Nasim Zamani, Hossein Hassanian-Moghaddam, Seyed Kaveh Hadeiy and Parinaz Parhizgar Tags: Research article Source Type: research

Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle
This study aimed to examine femoral bone microstructure of mice after single and simultaneous administration to acrylamide and ethanol since both substances are often consumed separately and/or together by hum... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 1, 2019 Category: Drugs & Pharmacology Authors: Anna Sarocka, Veronika Kovacova, Radoslav Omelka, Birgit Grosskopf, Edyta Kapusta, Zofia Goc, Grzegorz Formicki and Monika Martiniakova Tags: Research article Source Type: research

Safety and effectiveness of low-dose amikacin in nontuberculous mycobacterial pulmonary disease treated in Toronto, Canada
Treatment guidelines suggest either a low-dose or high-dose approach when prescribing amikacin for nontuberculous mycobacterial pulmonary disease (NTM PD), but data supporting the low-dose approach are limited... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 3, 2019 Category: Drugs & Pharmacology Authors: Maria Luisa Aznar, Theodore K. Marras, Ahmed Said Elshal, Mahtab Mehrabi and Sarah K. Brode Tags: Research article Source Type: research

Countrywide prevalence of critical drug interactions in Hungarian outpatients: a retrospective analysis of pharmacy dispensing data
Drug-drug interactions (DDIs) present a significant source of adverse drug reactions. Despite being one of the commonly cited risks to patient safety, prevention of DDIs still poses a challenge to healthcare s... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 31, 2019 Category: Drugs & Pharmacology Authors: Anna Somogyi-V égh, Zsófia Ludányi, Ábel Erdős and Lajos Botz Tags: Research article Source Type: research

Microbial epidemiology and antimicrobial resistance patterns of wound infection in Ethiopia: a meta-analysis of laboratory-based cross-sectional studies
Wound infections are responsible for significant human morbidity and mortality worldwide. Specifically, surgical site infections are the third most commonly reported nosocomial infections accounting approximat... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 30, 2019 Category: Drugs & Pharmacology Authors: Mekonnen Sisay, Teshager Worku and Dumessa Edessa Tags: Research article Source Type: research

Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities
Antibiotic-resistant pathogens are an emerging threat in this century. Epinecidin-1 is a multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides) has been shown to ha... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 28, 2019 Category: Drugs & Pharmacology Authors: Alireza Neshani, Hosna Zare, Mohammad Reza Akbari Eidgahi, Azad Khaledi and Kiarash Ghazvini Tags: Research article Source Type: research

Assessment of effect modification of statins on new-onset diabetes based on various medical backgrounds: a retrospective cohort study
The aim of this study was to investigate the association between statin use and new-onset diabetes in clinical settings and to assess its effect modification (heterogeneity) among patients with various medical... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 28, 2019 Category: Drugs & Pharmacology Authors: Keiko Yamazaki, Yasuo Takahashi, Kotoe Teduka, Tomohiro Nakayama, Yayoi Nishida and Satoshi Asai Tags: Research article Source Type: research

Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro
It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell functi... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 27, 2019 Category: Drugs & Pharmacology Authors: Jingwei Zhang, Guanghui Hu, Bisheng Huang, Dong Zhuo, Yujie Xu, Huitao Li, Xiangcheng Zhan, Ren-Shan Ge and Yunfei Xu Tags: Research article Source Type: research

Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study
Nephrotoxicity and ototoxicity are clinically significant dose-related adverse effects associated with second-line anti-tubercular injectables drugs (aminoglycosides and capreomycin) used during intensive phas... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 23, 2019 Category: Drugs & Pharmacology Authors: Workineh Shibeshi, Anandi N. Sheth, Addisu Admasu, Alemseged Beyene Berha, Zenebe Negash and Getnet Yimer Tags: Research article Source Type: research

Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis
Experimental pharmacology deals with effects of various test substances studied on different animal species which is aimed at finding out safe therapeutic agent suitable for public health as well as mechanism ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 21, 2019 Category: Drugs & Pharmacology Authors: Yilkal Tariku Belay Tags: Research article Source Type: research

One-year outcome of combination therapy with intravitreal aflibercept and photodynamic therapy for polypoidal choroidal vasculopathy
To investigate the one-year visual and anatomical outcomes of combination therapy with intravitreal aflibercept (IVA) and photodynamic therapy (PDT) for treating polypoidal choroidal vasculopathy (PCV). (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 14, 2019 Category: Drugs & Pharmacology Authors: Hsin-Yu Weng, Tzu-Lun Huang, Pei-Yao Chang and Jia-Kang Wang Tags: Research article Source Type: research

Near fatal intoxication by nicotine and propylene glycol injection: a case report of an e-liquid poisoning
Concern about intoxication by e-liquid is growing as calls to poison control centers have increased since their introduction. Only three cases of intoxication by injection have been reported worldwide. Our cas... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 10, 2019 Category: Drugs & Pharmacology Authors: Mhedi Belkoniene, Jennifer Socquet, Denise Njemba-Freiburghaus and Cyril Pellaton Tags: Case report Source Type: research

Abatacept induced granulomatous hepatitis with a sarcoidosis- like reaction: a blinded trial in mice
Abatacept is increasingly used for rheumatoid arthritis (RA) and juvenile idiophathic arthritis (JIA) treatment. However little is known about the risk of hepatotoxicity. The aim of this study was to determine... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 7, 2019 Category: Drugs & Pharmacology Authors: Sultan M. Almogairen Tags: Research article Source Type: research

Evaluation of prophylactic dosages of Enoxaparin in non-surgical elderly patients with renal impairment
Thromboprophylaxis dosing strategies using enoxaparin in elderly patients with renal disease are limited, while dose adjustments or monitoring of anti-Xa levels are recommended. We sought to evaluate the effic... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 7, 2019 Category: Drugs & Pharmacology Authors: Nibal Chamoun, Hady Ghanem, Ahmad Hachem, Essa Hariri, Christelle Lteif, Hanine Mansour, Hani Dimassi, Richard Zalloum and Georges Ghanem Tags: Research article Source Type: research

Nature and prevalence of adverse drug reaction of antiretroviral medications in Halibet National Referral Hospital: a retrospective study
This study was aimed at assessing... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 6, 2019 Category: Drugs & Pharmacology Authors: Lidya Hagos, Siyoma Fessehaye and Indermeet Singh Anand Tags: Research article Source Type: research