The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation
Surgical procedures cause perioperative immunosuppression and neuroendocrine stress, exerted by activation of the autonomic nervous system and the hypothalamic-pituitary-adrenal axis. The acetylcholinesterase ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 1, 2021 Category: Drugs & Pharmacology Authors: Mennatallah A Gowayed, Amany Abdel-Bary and Rasha A El-Tahan Tags: Research article Source Type: research
Transcriptome investigation of anti ‐inflammation and immuno‐regulation mechanism of taurochenodeoxycholic acid
Taurochenodeoxycholic acid (TCDCA) is one of the major active components in bile acid. It was proven to have inhibitory activities on inflammation and also participate in host immuno-regulation. TCDCA exerts a... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Lige Bao, Dacheng Hao, Xu Wang, Xiuling He, Wei Mao and Peifeng Li Tags: Research article Source Type: research
High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol
Low dose of NP exposure can alter adipose tissue formation, and the intake of high-fat diet (HFD) can also lead to the fatty liver disease. We investigated the combined effect of NP and HFD on the first offspr... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 27, 2021 Category: Drugs & Pharmacology Authors: Hongyu Zhang, Chengguang Song, Rong Yan, Hongbo Cai, Yi Zhou and Xiaoyu Ke Tags: Research Source Type: research
Subacute poisoning with bifenthrin increases the level of interleukin 1 ß in mice kidneys and livers
Bifenthrin is a pyrethroid. Chronic exposure of humans to the pesticide occurs. Reports about immunotoxicity and proinflammatory effect of pyrethroids were published. The aim of the article was to check if sub... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 26, 2021 Category: Drugs & Pharmacology Authors: Oktawia Pylak-Piwko and Barbara Nieradko-Iwanicka Tags: Research article Source Type: research
Opportunities for successful de-escalation of proton pump inhibitors at a federally qualified health center
A Proton Pump Inhibitor (PPI) de-escalation initiative was piloted at a Family Medicine Federally Qualified Health Center (FQHC) after a needs assessment showed that PPIs were prescribed inappropriately. The o... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 16, 2021 Category: Drugs & Pharmacology Authors: Joelle Ayoub, Jessina C. McGregor, Rebecca M. Castner and Harleen Singh Tags: Research article Source Type: research
The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism
Vitamin D deficiency is prevalent in patients with non-alcoholic fatty liver disease (NAFLD), but there are debates on the usefulness of vitamin D treatment. The interindividual variations in response may be d... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 7, 2021 Category: Drugs & Pharmacology Authors: Hamid Yaghooti, Fatemeh Ghanavati, Seyed Saeed Seyedian, Bahman Cheraghian and Narges Mohammadtaghvaei Tags: Research article Source Type: research
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice
Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecapt... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 7, 2021 Category: Drugs & Pharmacology Authors: Victoria K. Mwaeni, James N. Nyariki, Ngalla Jillani, George Omwenga, Mathew Ngugi and Alfred Orina Isaac Tags: Research article Source Type: research
Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whethe... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 20, 2021 Category: Drugs & Pharmacology Authors: Cevriye M ülkoğlu and Nermin Karaosmanoğlu Tags: Research article Source Type: research
Preliminary study of the toxicity and radioprotective effects of zymosan in vitro and in vivo
This study aimed to confirm the cytotoxicity of zymosan in vitro and in vivo and determine the appropriate treatment time and the dose of zymosan. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 17, 2021 Category: Drugs & Pharmacology Authors: Yue-zhi Zhang, Shu-jing Ge, Qing-zhen Leng, Jian-jun Ma and Han-chen Liu Tags: Research article Source Type: research
Bupivacaine inhibits a small conductance calcium ‐activated potassium type 2 channel in human embryonic kidney 293 cells
Bupivacaine blocks many ion channels in the heart muscle, causing severe cardiotoxicity. Small-conductance calcium-activated potassium type 2 channels (SK2 channels) are widely distributed in the heart cells a... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 12, 2021 Category: Drugs & Pharmacology Authors: Hongfei Chen, Zhousheng Jin, Fangfang Xia and Zhijian Fu Tags: Research article Source Type: research
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19
The impact of prior exposure to systemic corticosteroids on COVID-19 severity in patients hospitalized for a SARS-CoV-2 pneumonia is not known. The present study was designed to answer to this question. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 11, 2021 Category: Drugs & Pharmacology Authors: Margaux Lafaurie, Guillaume Martin-Blondel, Pierre Delobel, Nassim Kamar, Sandrine Charpentier, Agn ès Sommet and Guillaume Moulis Tags: Research article Source Type: research
Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients
Linezolid is administered as a fixed dose to all patients despite evidence of overexposure and thrombocytopenia in renal impairment. The aims of this study were to evaluate the risk of thrombocytopenia and the... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 4, 2021 Category: Drugs & Pharmacology Authors: Hitoshi Kawasuji, Yasuhiro Tsuji, Chika Ogami, Kou Kimoto, Akitoshi Ueno, Yuki Miyajima, Koyomi Kawago, Ippei Sakamaki and Yoshihiro Yamamoto Tags: Research article Source Type: research
Patient safety and public health concerns: poor dissolution rate of pioglitazone tablets obtained from China, Myanmar and internet sites
Poor quality medicines have serious implications for public health. The aim of this study was to explore the quality of the antidiabetic pioglitazone, using samples collected in China and Myanmar, and samples ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 2, 2021 Category: Drugs & Pharmacology Authors: Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Erina Maeda, Andrea Vanessa Velasco Ibarra, Theingi Zin, Yoshio Akimoto, Tsuyoshi Tanimoto and Kazuko Kimura Tags: Research article Source Type: research
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile
Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially for anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 4, 2021 Category: Drugs & Pharmacology Authors: Ioana-Mirela Vasincu, Maria Apotrosoaei, Sandra Constantin, Maria Butnaru, Liliana Vere știuc, Cătălina-Elena Lupușoru, Frederic Buron, Sylvain Routier, Dan Lupașcu, Roxana-Georgiana Taușer and Lenuța Profire Tags: Research article Source Type: research
New onset diabetes mellitus and cardiovascular events in Korean patients with acute myocardial infarction receiving high-intensity statins
High-intensity statin therapy is typically used in patients with acute myocardial infarction (AMI) for secondary prevention. However, there have been consistent concerns regarding its association with diabetes... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 4, 2021 Category: Drugs & Pharmacology Authors: Jah Yeon Choi, Cheol Ung Choi, Byoung Geol Choi, Yoonjee Park, Dong Oh Kang, Won Young Jang, Woohyeun Kim, Jin Oh Na, Jin Won Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Myung Ho Jeong, Sung-Chull Chae, In-Whan Seong & hellip; Tags: Research article Source Type: research
