Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data
Digoxin is an important treatment option for reducing the ventricular rate in patients with atrial fibrillation (AF) and heart failure (HF). Digoxin has a narrow therapeutic window and large interindividual va... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 10, 2022 Category: Drugs & Pharmacology Authors: Toshinori Hirai, Hidefumi Kasai, Miyoko Naganuma, Nobuhisa Hagiwara and Tsuyoshi Shiga Tags: Research article Source Type: research
Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis
This study investigated whet... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 5, 2022 Category: Drugs & Pharmacology Authors: Zhen Yu, Jun Guo, Tao Meng, Lei Ge, Lin Liu, Haijiang Wang and Xinhui Yang Tags: Research Source Type: research
Cordycepin inhibits colon cancer proliferation by suppressing MYC expression
This study aimed to investigate the effect of cor... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 4, 2022 Category: Drugs & Pharmacology Authors: Zhe Zhang, Kui Li, Zhi Zheng and Yu Liu Tags: Research Source Type: research
Correction to: Open-access database of literature derived drug-related Torsade de Pointes cases
An amendment to this paper has been published and can be accessed via the original article. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 31, 2022 Category: Drugs & Pharmacology Authors: Laura Krumpholz, Barbara Wi śniowska and Sebastian Polak Tags: Correction Source Type: research
Novel dihydroartemisinin derivative Mito-DHA5 induces apoptosis associated with mitochondrial pathway in bladder cancer cells
Bladder cancer is the second most common genitourinary malignancy and the eleventh most common cancer worldwide. Dihydroartemisinin (DHA), a first-line antimalarial drug, has been found to have potent antitumo... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 20, 2022 Category: Drugs & Pharmacology Authors: Linfan Xiao, Cangcang Xu, Peiyu Lin, Lingli Mu and Xiaoping Yang Tags: Research Source Type: research
Comparative risk of incidence and clinical outcomes of COVID-19 among proton pump inhibitor and histamine-2 receptor antagonist short-term users: a nationwide retrospective cohort study
This study aimed to evaluate incidence risk and adverse clinical outcomes in COVID-19 disease among short-term users of acid-suppressants in South Korea. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 17, 2022 Category: Drugs & Pharmacology Authors: Jimyung Park, Seng Chan You, Jaehyeong Cho, Chan Hyuk Park, Woon Geon Shin, Rae Woong Park and Seung In Seo Tags: Research Source Type: research
Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome
Patients with liver diseases often have some form of anemia. Hematological dyscrasias are known side effects of antipsychotic drug medication and the occurrence of agranulocytosis under clozapine is well descr... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 15, 2022 Category: Drugs & Pharmacology Authors: Marie-Luise Bouvier, Karin Fehsel, Andrea Schmitt, Eva Meisenzahl-Lechner, Wolfgang Gaebel and Martina von Wilmsdorff Tags: Research article Source Type: research
Open-access database of literature derived drug-related Torsade de Pointes cases
Since an introduction of an ICH guidance in 2005, no new drugs were withdrawn from the market because of the causation of Torsade de Pointes (TdP). However, the risk of TdP is still a concern for marketed drug... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 10, 2022 Category: Drugs & Pharmacology Authors: Krumpholz Laura, Wi śniowska Barbara and Polak Sebastian Tags: Database Source Type: research
Comparison of two biosimilarity studies of FKB327 with the adalimumab reference product: randomized phase 1 studies of single-blind, single-dose subcutaneous injection in healthy Japanese male participants
FKB327 has been developed as a biosimilar of the adalimumab reference product (RP). We compared the pharmacokinetics (PK), safety, and immunogenicity of FKB327 with those of the adalimumab RP after a single do... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 8, 2022 Category: Drugs & Pharmacology Authors: Takuma Yonemura, Rie Yazawa, Miwa Haranaka, Kazuki Kawakami, Masayuki Takanuma, Takumi Kanzo, Dimitris Stefanidis and Yasumasa Arai Tags: Research Source Type: research
The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
Pregabalin (PGB) was approved as new anti-epileptic drugs with little information about its teratogenic effect. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 5, 2022 Category: Drugs & Pharmacology Authors: Omnia I. Ismail, Eman S. Shaltout, Nora Z. Abdellah, Diab F. Hetta, Wael M. A. Abd El-Ghani, Lobna A. Abdelzaher, Ahmed Mohamed Mohamed Mahmoud, Asmaa M. Hasan, Noha A. Rashed and Noha Esmael Ebrahem Tags: Research Source Type: research
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines
The United Kingdom guideline for acute paracetamol overdose has recommended the use of ‘100-treatment line’. Emergency medical centers in some developing countries lack the resources for timely reporting of pa... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 5, 2022 Category: Drugs & Pharmacology Authors: Hyun Ho Jeong, Kyungman Cha, Kyoung Ho Choi and Byung Hak So Tags: Research Source Type: research
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro
Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effe... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 4, 2022 Category: Drugs & Pharmacology Authors: Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena and Augustine Ocloo Tags: Research Source Type: research
The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line
Despite significant advancements in breast cancer therapy, novel drugs with lower side effects are still being demanded. In this regard, we investigated the anti-cancer features of verbascoside in 4 T1 mouse m... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 29, 2021 Category: Drugs & Pharmacology Authors: Atena Daneshforouz, Samad Nazemi, Omid Gholami, Marzieh Kafami and Bahareh Amin Tags: Research Source Type: research
In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica
Leishmania aethiopica (L. aethiopica) is responsible for different forms of cutaneous leishmaniasis (CL) in Ethiopia. Treatment heavily depends on limited drugs, together with drawbacks like toxicity and microbia... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 16, 2021 Category: Drugs & Pharmacology Authors: Markos Tadele, Solomon M. Abay, Peter Asaga, Eyasu Makonnen and Asrat Hailu Tags: Research Source Type: research
Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway
Gastric cancer is a common gastrointestinal cancer and currently has the third-highest mortality rate. Research shows that the natural compound narciclasine has a variety of biological activities. The present ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 9, 2021 Category: Drugs & Pharmacology Authors: Yunfeng Yuan, Xue He, Xiang Li, Yan Liu, Yueliang Tang, Huiming Deng and Xinyuan Shi Tags: Research Source Type: research
