Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats
The present study investigated the ameliorative effect of melittin, a major polypeptide in the venom of honeybee (Apis mellifera), on isoniazid-(INH) and rifampicin-(RIF) induced hepatotoxicity in male albino rat... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 3, 2021 Category: Drugs & Pharmacology Authors: Khalid Mohammed Naji, Bushra Yahya Al-Khatib, Nora Saif Al-Haj and Myrene R. D ’souza Tags: Research article Source Type: research
Safety assessment of subtilisin QK in rats
Subtilisin QK is a serine protease in the subtilisin family, and is fermented by Bacillus subtilis QK02. The fibrinolytic activity of subtilisin QK was measured by detecting low molecular weight degradation produ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao, Dingbang Hu, Ya Gao, Yang Ai, Sang Luo, Song Chen, Ben Wang, Li Zhou, Yanshan Dong and Yefu Wang Tags: Research Source Type: research
Correction to: Superior silybin bioavailability of silybin –phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*
(Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 25, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez, Miguel Dibildox-Martinez, Jahir Sosa-Noguera, Ramón Sánchez-Medal and Francisco J. Flores-Murrieta Tags: Correction Source Type: research
In-silico evaluation of Malawi essential medicines and reactive metabolites for potential drug-induced toxicities
Drug-induced toxicity is one of the problems that have negatively impacted on the well-being of populations throughout the world, including Malawi. It results in unnecessary hospitalizations, retarding the dev... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 16, 2021 Category: Drugs & Pharmacology Authors: Ibrahim Chikowe, Alfred Chipanda Phiri, Kirios Patrick Mbewe and Dunstan Matekenya Tags: Research Source Type: research
Effect of perioperative use of parecoxib on chronic post-surgical pain in elderly patients after hepatectomy: a prospective randomized controlled study
This study aimed to test the superiority of parecoxib vs. placebo in prev... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 15, 2021 Category: Drugs & Pharmacology Authors: Xiaodong Ge, Yan Pan, Danfeng Jin, Ying Wang and Shengjin Ge Tags: Research article Source Type: research
Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin
Patients with type 2 diabetes mellitus (T2DM) are characterized by an elevated glycemic index and are at a higher risk for complications such as cardiovascular disease, nephropathy, retinopathy and peripheral ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 13, 2021 Category: Drugs & Pharmacology Authors: Robert Dobbins, Elizabeth K. Hussey, Robin O ’Connor-Semmes, Susan Andrews, Wenli Tao, William O. Wilkison, Bentley Cheatham, Katare Sagar and Barkate Hanmant Tags: Research article Source Type: research
Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats
The objective of the present study was to determine the effect of allisartan, a new angiotensin II type 1 receptor antagonist on vascular remodeling through voltage gated potassium channels (Kv7) in hypertensi... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 9, 2021 Category: Drugs & Pharmacology Authors: Xiaoqin Zhang, Ziying Zhao, Chunfang Xu, Fengping Zhao and Zhiqiang Yan Tags: Research Source Type: research
Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Iran
Acinetobacter baumannii is an opportunistic pathogen that can cause several kinds of nosocomial infections. Increasing antibiotic resistance as well as identifying genetic diversity and factors associated with pa... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 8, 2021 Category: Drugs & Pharmacology Authors: Maryam Hazhirkamal, Omid Zarei, Mahsa Movahedi, Pezhman Karami, Leili Shokoohizadeh and Mohammad Taheri Tags: Research Source Type: research
Protective effect of alamandine on doxorubicin ‑induced nephrotoxicity in rats
This study aimed to evaluate the protective effects of alamandine, a new member of the angiotensin family, against doxorubicin (DOX)-induced nephrotoxicity in rats. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 29, 2021 Category: Drugs & Pharmacology Authors: Ava Soltani Hekmat, Ameneh Chenari, Hiva Alipanah and Kazem Javanmardi Tags: Research Source Type: research
Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock
The aim of this study is to examine the association of hypophosphatemia and hyperphosphatemia on the first day of ICU admission with mortality in septic critically ill patients. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 28, 2021 Category: Drugs & Pharmacology Authors: Shmeylan A. Al Harbi, Hasan M. Al-Dorzi, Albatool M. Al Meshari, Hani Tamim, Sheryl Ann I. Abdukahil, Musharaf Sadat and Yaseen Arabi Tags: Research article Source Type: research
Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe
Drug potency is a pharmacological parameter defining dose or concentration of drug required to obtain 50% of the drug ’s maximal effect. Pharmacokinetic-pharmacodynamic modelling and simulation allows estimatio... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 24, 2021 Category: Drugs & Pharmacology Authors: Bernard Ngara, Simbarashe Zvada, Tariro Dianah Chawana, Charles Fungai Brian Nhachi and Simbarashe Rusakaniko Tags: Research article Source Type: research
Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway
In this work, we investigated the effects of gambogic acid (GA) on lipopolysaccharide (LPS)-induced apoptosis and inflammation in a cell model of neonatal pneumonia. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 11, 2021 Category: Drugs & Pharmacology Authors: Xu Gao, Jingya Dai, Guifang Li and Xinya Dai Tags: Research Source Type: research
Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice
Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 7, 2021 Category: Drugs & Pharmacology Authors: Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota and Shintaro Kinugawa Tags: Research Source Type: research
Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy
We aim to develop a population pharmacokinetics (PopPK) model of vancomycin for the treatment of septicemia in infants younger than one year. Factors influence of the PK was investigated to optimize vancomycin... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 4, 2021 Category: Drugs & Pharmacology Authors: Zhiling Li, Hongjing Li, Chenyu Wang, Zheng Jiao, Feng Xu and Huajun Sun Tags: Research article Source Type: research
Epidemiology, clinical presentation, treatment, and follow ‐up of chronic mercury poisoning in China: a retrospective analysis
This study investigated the epidemiology, clinical manifestations, treatment, and follow-up of Chinese patient... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 3, 2021 Category: Drugs & Pharmacology Authors: Sun Yawei, Long Jianhai, Zhao Junxiu, Peng Xiaobo and Qiu Zewu Tags: Research article Source Type: research
