Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model
In this study, micelle formulation of BBR was investigated to improve therapeutic ef... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 3, 2021 Category: Drugs & Pharmacology Authors: Roza Azadi, Seyyedeh Elaheh Mousavi, Negar Motakef Kazemi, Hasan Yousefi-Manesh, Seyed Mahdi Rezayat and Mahmoud Reza Jaafari Tags: Research Source Type: research
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have become significant global health concerns. In the present study, we aimed to investigate the effects of saroglitazar, a d... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Rasoul Akbari, Tahereh Behdarvand, Reza Afarin, Hamid Yaghooti, Mohammad Taha Jalali and Narges Mohammadtaghvaei Tags: Research Source Type: research
High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines
The cancer burden is rising rapidly worldwide, and it annually causes about 8.8 million deaths worldwide. Due to chemical drugs ’ side effects and the emergence of resistance, the development of new green drugs... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 30, 2021 Category: Drugs & Pharmacology Authors: Alireza Valizadeh, Ali Asghar Khaleghi, Ghazaal Roozitalab and Mahmoud Osanloo Tags: Research Source Type: research
Acute and subacute toxicity evaluation of hydroalcoholic extract from the stem bark of Bois Bande (Parinari campestris Aubl.1772) in rats
The bark of Bois Bande (Parinari campestris) is a popular aphrodisiac in the Caribbean that has been traditionally used for many years to restore sexual vitality, increase sperm count, and treat erectile dysfunct... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Venkatesan Sundaram, Stephanie Mohammed, M. R. Srinivasan, Jenelle Johnson, Rod Suepaul, Indira Pargass, Chernell John, Danesha Ramdhanie, Shiann Lallack, Esther Daniel and Lester Gilkes Tags: Research Source Type: research
Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice
In septic mice, supplementing parenteral nutrition with 150 mg/day 3-hydroxybutyrate-sodium-salt (3HB-Na) has previously shown to prevent muscle weakness without obvious toxicity. The main objective of this st... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 20, 2021 Category: Drugs & Pharmacology Authors: Ruben Weckx, Chlo ë Goossens, Sarah Derde, Lies Pauwels, Sarah Vander Perre, Greet Van den Bergh and Lies Langouche Tags: Research article Source Type: research
Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment
Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provid... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 16, 2021 Category: Drugs & Pharmacology Authors: Brian Sacks, Halil Onal, Rose Martorana, Amogh Sehgal, Amanda Harvey, Catherine Wastella, Hafsa Ahmad, Erin Ross, Adona Pjetergjoka, Sachin Prasad, Robert Barsotti, Lindon H. Young and Qian Chen Tags: Research article Source Type: research
Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma
Aidi Injection (ADI), a Chinese herbal preparation with anti-cancer activity, is used for the treatment of hepatocellular carcinoma (HCC). Several clinical studies have shown that co-administration of ADI with... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 6, 2021 Category: Drugs & Pharmacology Authors: Yuan Lu, Jie Pan, Xiaoqing Zhu, Shuai Zhang, Chunhua Liu, Jia Sun, Yueting Li, Siying Chen, Jing Huang, Chuang Cao, Yonglin Wang, Yongjun Li and Ting Liu Tags: Research article Source Type: research
Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese adverse drug event report database
Acute kidney injury (AKI) is associated with significant increases in short- and long-term morbidity and mortality. Drug-induced AKI is a major concern in the present healthcare system. Our spontaneous reporti... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 30, 2021 Category: Drugs & Pharmacology Authors: Satoshi Nakao, Shiori Hasegawa, Ryogo Umetsu, Kazuyo Shimada, Ririka Mukai, Mizuki Tanaka, Kiyoka Matsumoto, Yu Yoshida, Misaki Inoue, Riko Satake, Yuri Nishibata, Jun Liao and Mitsuhiro Nakamura Tags: Research article Source Type: research
Quality of selected anti-retroviral medicines: Tanzania Mainland market as a case study
Antiretroviral drugs (ARVs) have significantly reduced morbidity, mortality and improved the quality of life of people living with HIV infection. Poor quality ARVs may result in harmful consequences such as ad... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 26, 2021 Category: Drugs & Pharmacology Authors: Sophia Mziray, Betty A. Maganda, Kissa Mwamwitwa, Adam M. Fimbo, Seth Kisenge, Gerald Sambu, Yonah H. Mwalwisi, Adonis Bitegeko, Emmanuel Alphonce, Akida Khea, Danstan H. Shewiyo and Eliangiringa Kaale Tags: Research article Source Type: research
Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies
Abnormally elevated xanthine oxidase (XO) activity has been verified to cause various pathological processes, such as gout, oxidative stress injury and metabolic syndrome. Thus, XO activators may exhibit above... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 17, 2021 Category: Drugs & Pharmacology Authors: Liang Yue, Nan Jiang, Anguo Wu, Wenqiao Qiu, Xin Shen, Dalian Qin, Hong Li, Jing Lin, Sicheng Liang and Jianming Wu Tags: Research Source Type: research
Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence
Esculetin is a natural coumarin derivative from various plants with multiple pharmacological effects. Hence, the present study was undertaken to explore the cardio protective potential of esculetin against iso... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 15, 2021 Category: Drugs & Pharmacology Authors: Chitikela P. Pullaiah, Vinod K. Nelson, Sushma Rayapu, Narasimha Kumar G V and Thyagaraju Kedam Tags: Research Source Type: research
Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells
Helicobacter pylori (H. pylori) is a common pathogen in development of peptic ulcers with pyroptosis. Rabeprazole, a critical component of standard triple therapy, has been widely used as the first-line regimen f... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 15, 2021 Category: Drugs & Pharmacology Authors: Jing Xie, Long Fan, Liya Xiong, Peiyu Chen, Hongli Wang, Huan Chen, Junhong Zhao, Zhaohui Xu, Lanlan Geng, Wanfu Xu and Sitang Gong Tags: Research Source Type: research
Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid
Recently, the development of nanocarriers and the improvement of their biochemical properties have became of great importance. Single-walled carbon nanotubes (SWCNT) have many applications in drug delivery sys... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Mohammad Dahri, Hossein Akbarialiabad, Ahmad Miri Jahromi and Reza Maleki Tags: Research article Source Type: research
In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria
Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects suc... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Parvin Askari, Mohammad Hasan Namaei, Kiarash Ghazvini and Mehran Hosseini Tags: Research Source Type: research
Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence
Ethnic differences in testicular cancer rates (TCRs) are recognized internationally. Cannabis is a known risk factor for testicular cancer (TC) in multiple studies with dose-response effects demonstrated, howe... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 11, 2021 Category: Drugs & Pharmacology Authors: Albert Stuart Reece and Gary Kenneth Hulse Tags: Research Source Type: research
