Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rats: a comparative study
Testicular torsion is a pathological condition which needs emergency surgical intervention. However, after surgical reperfusion, oxidative stress factors cause to germ cell apoptosis. The study was planned to ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 5, 2022 Category: Drugs & Pharmacology Authors: Iraj Yazdani, Raheleh Majdani, Morteza Ghasemnejad-berenji and Ahmad Reza Dehpour Tags: Research Source Type: research
Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential
The present study aims to investigate the newly synthesized organotin (IV) complex (2E, 2 ′E) dibutylstannanediyl bis (4-(4-nitrophenyl) amino)-4-oxobut-2-enoate (DTN) for its anti-ulcer potential. Characteriza... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 29, 2022 Category: Drugs & Pharmacology Authors: Syed Azmatullah, Arif-ullah Khan, Neelam Gul Qazi, Humaira Nadeem and Nadeem Irshad Tags: Research Source Type: research
A randomized, double-blind, phase III, non-inferiority clinical trial comparing the efficacy and safety of TA4415V (a proposed Trastuzumab biosimilar) and Herceptin (Trastuzumab reference product) in HER2-positive early-stage breast Cancer patients
This study compared efficacy and safety of TA4415V, a trastuzumab biosimilar, with reference trastuzumab in patients with human epidermal growth factor receptor 2 –positive (HER2-positive) early-stage breast cance... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 28, 2022 Category: Drugs & Pharmacology Authors: Reza Safaei Nodehi, Behjat Kalantari, Jahangir Raafat, Nafiseh Ansarinejad, Vahid Moazed, Seyed Mohammad Reza Mortazavizadeh, Mehran Hosseinzadeh, Bayazid Ghaderi, Arash Jenabian, Mojtaba Qadyani, Shirin Haghighat, Abolghasem Allahyari, Mehrzad Mirzania, Tags: Research Source Type: research
The effects of mifepristone on the structure of human decidua and chorion and Bax and Bcl-2 expression at early stage of pregnancy
As a progesterone receptor antagonist, mifepristone combined with misoprostol is widely used to terminate early pregnancy in clinical practice. It has also been reported that mifepristone may cause cell death ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 23, 2022 Category: Drugs & Pharmacology Authors: Fei Tian, Hua Han, Ligang Jia, Junqin Zhang, Zhaoping Chu, Jie Li, Yuan Zhang and Ping Yan Tags: Research Source Type: research
Cytotoxic and apoptotic potential of gemini-chrysophanol nanoparticles against human colorectal cancer HCT-116 cell lines
Colorectal cancer is among the most common cancers and accounts for nearly 9% of all cancers in the world. Chrysophanol is a naturally occurring anthraquinone exerts a number of pharmacological activities s... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 23, 2022 Category: Drugs & Pharmacology Authors: Alaadin M. Naqishbandi Tags: Research article Source Type: research
Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability
Liver fibrosis is a wound-healing response to chronic injury, featuring with excess accumulation of extracellular matrix secreted by the activated hepatic stellate cells (HSC). Disulfiram (DSF), also known as ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 22, 2022 Category: Drugs & Pharmacology Authors: Xiao-Mei Yang, Zheng Wu, Xiaoqi Wang, Yaoqi Zhou, Lei Zhu, Dongxue Li, Hui-Zhen Nie, Ya-Hui Wang, Jun Li and Xueyun Ma Tags: Research Source Type: research
Development of a particle swarm optimization-backpropagation artificial neural network model and effects of age and gender on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese population
The effects of age and gender were explored on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese population and a plasma concentration prediction model was developed. All the data (demogra... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 19, 2022 Category: Drugs & Pharmacology Authors: Yichao Xu, Jinliang Chen, Dandan Yang, Yin Hu, Bo Jiang, Zourong Ruan and Honggang Lou Tags: Research Source Type: research
Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions
Polysorbate 80 for injection (TW80) is a common excipient used for injection whose macromolecular impurities, including those that cause anaphylactoid reactions, are frequently ignored. The main aim of this st... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 18, 2022 Category: Drugs & Pharmacology Authors: Yue Li, Jinlian Duan, Heng Xia, Yongkun Li, Bin Shu and Weigang Duan Tags: Research Source Type: research
Real-world safety of ulinastatin: a post-marketing surveillance of 11,252 patients in China
The safety assessment of ulinastatin can guide clinical practice. The present study aimed to investigate the real-world safety of ulinastatin in China. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 16, 2022 Category: Drugs & Pharmacology Authors: Jin Li, Meijun Li, Liren Li, Lin Ma, Ailin Cao, Aiping Wen, Wenge Chen, Lingling Li, Yan Liang and Jianxiong Deng Tags: Research Source Type: research
Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model
Administration of antineoplastic drugs may cause azoospermia driving to subfertility. Production of animal azoospermia models is essential for evaluating new treatment methods before therapeutic interventions ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 14, 2022 Category: Drugs & Pharmacology Authors: Halimeh Mobarak, Reza Rahbarghazi, Mohammad Nouri, Mohammad Heidarpour and Mahdi Mahdipour Tags: Research Source Type: research
Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System
With diabetes incidence growing globally and metformin still being the first-line for its treatment, metformin ’s toxicity and overdose have been increasing. Hence, its mortality rate is increasing. For the fir... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 13, 2022 Category: Drugs & Pharmacology Authors: Omid Mehrpour, Farhad Saeedi, Christopher Hoyte, Foster Goss and Farshad M. Shirazi Tags: Research Source Type: research
A novel nitidine chloride nanoparticle overcomes the stemness of CD133+EPCAM+ Huh7 hepatocellular carcinoma cells for liver cancer therapy
In this study, we evaluated the tumorcidal activity of a nov... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 12, 2022 Category: Drugs & Pharmacology Authors: Danni Li, Qiying Zhang, Yuzhu Zhou, Hua Zhu, Tong Li and Fangkai Du Tags: Research Source Type: research
Resveratrol ’s neural protective effects for the injured embryoid body and cerebral organoid
Resveratrol (RSV) is a polyphenol compound found in grapes, veratrum and other plants. It has been reported that RSV has anti-inflammatory, anti-oxidant, anti-cancer and other pharmacological effects. However,... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 12, 2022 Category: Drugs & Pharmacology Authors: Yanli Wang, Tingting Wei, Qiang Wang, Chaonan Zhang, Keyan Li and Jinbo Deng Tags: Research Source Type: research
Long-term low-dose exposure of permethrin induces liver and kidney damage in rats
Permethrin is one of the pyrethroid insecticides, which is widely used in agriculture and public health. Although acute toxicity of the insecticide has been studied, the chronic toxicity upon the long-term exp... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 8, 2022 Category: Drugs & Pharmacology Authors: Ying-Jian Sun, Yu-Jie Liang, Lin Yang, Ding-Xin Long, Hui-Ping Wang and Yi-Jun Wu Tags: Research Source Type: research
Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions
This study was conducted to compare the pharmacokinetic paramet... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 7, 2022 Category: Drugs & Pharmacology Authors: Ting Li, Yan-ping Liu, Shu-qin Liu, Ping Shi, Xin Jiang, Ye Tao, Xiao-meng Gao, Ya-ping Ma and Yu Cao Tags: Research Source Type: research
