Controlled release of silica-coated insulin-loaded chitosan nanoparticles as a promising oral administration system
Oral insulin administration has recently become one of the most exciting research subjects. Different approaches have been carried out to get an effective oral insulin delivery system using nanotechnology. The... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 30, 2023 Category: Drugs & Pharmacology Authors: Mohamed M. Fathy, Asmaa A. Hassan, Anwar A. Elsayed and Heba M. Fahmy Tags: Research Source Type: research
Thiram, an inhibitor of 11 ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway
The anti-osteosarcoma effects of hydrocortisone and thiram, an inhibitor of type 2 11 ß-hydroxysteroid dehydrogenase (11HSD2), have not been reported. The purpose of this study was to investigate the effects of... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 28, 2023 Category: Drugs & Pharmacology Authors: You Zhang, Nanjing Li, He Li, Maojia Chen, Wei Jiang and Wenhao Guo Tags: Research Source Type: research
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity
The severe unfavorable effects of doxorubicin on the heart restrict its clinical usage. Numerous investigations document that cyclic GMP-AMP synthase (cGAS) activator of interferon genes (STING) cascade influe... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 24, 2023 Category: Drugs & Pharmacology Authors: Zilong Xiao, Ziqing Yu, Chaofeng Chen, Ruizhen Chen and Yangang Su Tags: Research Source Type: research
Correction: Cardioprotective effect of crude polysaccharide fermented by Trametes Sanguinea Lyoyd on doxorubicin-induced myocardial injury mice
(Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Chenjun Shen, Bo Yang, Lili Huang, Yueru Chen, Huajun Zhao and Zhihui Zhu Tags: Correction Source Type: research
The toxic effects of anabolic steroids “nandrolone decanoate” on cardiac and skeletal muscles with the potential ameliorative effects of silymarin and fenugreek seeds extract in adult male albino rats
Anabolic steroids (AS) are commonly abused by body builders and athletes aiming to increase their strength and muscle mass but unfortunately, the long-term use of AS may lead to serious side effects. Nandrolon... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Dalia Abd Elwahab Hassan, Sherien S. Ghaleb, Amr reda Zaki, Ahmed Abdelmenem, Shimaa Nabil and Mostafa Abdallah Abdel Alim Tags: Research Source Type: research
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress
Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 7, 2023 Category: Drugs & Pharmacology Authors: Haiyan Wang, Hanqing Lin, Weibiao Kang, Lingfei Huang, Sisi Gong, Tao Zhang, Xiaotong Huang, Feinan He, Yongyi Ye, Yiyang Tang, Haiying Jia and Haidi Yang Tags: Research Source Type: research
Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration Adverse Event Reporting System (FAERS)
Osteonecrosis of the jaw (ONJ) is a rare but serious adverse drug reaction (ADR) commonly associated with bisphosphonate and denosumab therapy. Prior research utilized an online, public FDA Adverse Event Repor... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 6, 2023 Category: Drugs & Pharmacology Authors: Hardeep S. Ahdi, Thomas Adam Wichelmann, Sasirekha Pandravada and Eli D. Ehrenpreis Tags: Research article Source Type: research
Pharmacokinetics and safety of two Voriconazole formulations after intravenous infusion in two doses in healthy Chinese subjects
Voriconazole is a second-generation triazole that is used to prevent and treat invasive fungal infections. The purpose of this study was to evaluate the pharmacokinetic equivalency of a test formulation and re... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 3, 2023 Category: Drugs & Pharmacology Authors: Xin Li, Chenjing Wang, Ping Shi, Yanping Liu, Ye Tao, Pingping Lin, Ting Li, Haixun Hu, Feifei Sun, Shuqin Liu, Yao Fu and Yu Cao Tags: Research Source Type: research
Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy
Albumin-bound paclitaxel (nab-paclitaxel), as a special targeted preparation of paclitaxel, has the advantages of good curative effect and less side effects in anti-tumor therapy. The existence of the plasma-p... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 1, 2023 Category: Drugs & Pharmacology Authors: Jingjing Zhang, Luya Li, Jintuo Yin, Xidong Zhang, Ying Zheng and Rui Feng Tags: Research Source Type: research
Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats
Chlorine is a chemical threat agent that can be harmful to humans. Inhalation of high levels of chlorine can lead to acute lung injury (ALI). Currently, there is no satisfactory treatment, and effective antido... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 27, 2023 Category: Drugs & Pharmacology Authors: Meng-meng Liu, Jiang-zheng Liu, Chen-qian Zhao, Peng Guo, Zhao Wang, Hao Wu, Weihua Yu, Rui Liu, Chun-xu Hai and Xiao-di Zhang Tags: Research Source Type: research
Sea urchin (Diadema savignyi) extract as a novel protective agent against cisplatin induced neurotoxicity in rats
Neurotoxicity is a severe side effect of platinum compounds used for cancer chemotherapy such as Cisplatin. This neurotoxicity leads to severe cognitive and nervous dysfunction, therefore, limiting the dose of... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 23, 2023 Category: Drugs & Pharmacology Authors: Eman A. Khalil, Hamdy Swelim, Hala El-Tantawi and Ahmed Abdellatif Tags: Research Source Type: research
Oseltamivir phosphate for suspension is bioequivalent to TAMIFLU in healthy volunteers: a randomized, open-label clinical study
The study was aimed at evaluating the bioequivalence and safety of oseltamivir phosphate for suspension, provided by Shenzhen Beimei Pharmaceutical Co. Ltd. and manufactured by Hetero Labs Limited, and the ref... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 21, 2023 Category: Drugs & Pharmacology Authors: Ying Wang, Bangzhong Tang, Jing Xie, Xiaoqin Wang, Peng Ren, Guangmei Wu, Cuixia He, Minhui Zhu, Yue Su, Jiaxiang Ding, Yuanyuan Xu, Ling Fan, Qin Ge, Yuzhou Ding, Juan Zhu, Bingyan Liu & hellip; Tags: Research Source Type: research
Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice
Seizures are considered to be the most common symptom encountered in emergency- rushed tramadol-poisoned patients; accounting for 8% of the drug-induced seizure cases. Although, diazepam clears these seizures,... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 9, 2023 Category: Drugs & Pharmacology Authors: Shaimaa A. ElShebiney, Rania Elgohary, Sayed H. Kenawy, Gehan T. El-Bassyouni and Esmat M. A. Hamzawy Tags: Research Source Type: research
Behavioral, biochemical and histopathological toxic profiles induced by sub-chronic cannabimimetic WIN55, 212 –2 administration in mice
WIN55, 212 –2 mesylate is a synthetic cannabinoid (SC) agonist of CB1 and CB2 receptors with much higher affinity to CB1 receptor than tetrahydrocannabinol and many potential therapeutic effects. Few studies ha... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 7, 2023 Category: Drugs & Pharmacology Authors: Ghada A. Omran, Eman S. H. Abd Allah, Sherine Ahmed Mohammed and Doaa M. El Shehaby Tags: Research Source Type: research
Profile and outcomes of acute poisoning in the toxicology treatment and control center at Tanta University Hospital, Egypt
Poisoning is a major health problem especially in developing countries and leads to high morbidity and mortality. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 3, 2023 Category: Drugs & Pharmacology Authors: Omar El-Sayed Rageh, Hamdy Khaled Sabra, Abdulrahman Abdullah Alammar, Omar Naif Alanazi, Ayman Nagy and Ibrahim Ali Kabbash Tags: Research Source Type: research
