A phase I study comparing the biosimilarity of the pharmacokinetics and safety of recombinant humanized anti-vascular endothelial growth factor monoclonal antibody injection with Avastin ® in healthy Chinese male subjects
The biosimilar landscape for malignancies continues to grow, with several biosimilars for reference product bevacizumab currently available. Bevacizumab has been shown to be well tolerated; however, the safety... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 27, 2023 Category: Drugs & Pharmacology Authors: Hongtao Li, Xiangdi Zhao, Jing Xie, Xingyu Zhu, Yue Su, Cuixia He, Jiaxiang Ding, Minhui Zhu, Yuanyuan Xu, Ying Wang, Rongfang Shan, Bingyan Liu, Yuzhou Ding, Yuanyuan Liu, Huan Zhou and Yunqiu Xie Tags: Research Source Type: research
In vitro comparative quality evaluation of different brands of carbamazepine tablets commercially available in Dessie town, Northeast Ethiopia
Good-quality drugs that fulfill the regulatory parameters and are produced per the current good manufacturing practice (cGMP) standards are very critical for the best therapeutic outcomes. However, the variety... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 25, 2023 Category: Drugs & Pharmacology Authors: Biset Asrade, Ejigu Tessema and Abebe Tarekegn Tags: Research Source Type: research
Vanillic acid alleviates methamphetamine-induced mitochondrial toxicity in cardiac mitochondria via antioxidant activity and inhibition of MPT Pore opening: an in-vitro study
Methamphetamine is widely abused in all parts of the world. It has been reported that short-term and long-term methamphetamine exposure could damage the dopaminergic system and induce cardiomyopathy and cardio... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 19, 2023 Category: Drugs & Pharmacology Authors: Mohammad Shabani, Zhaleh Jamali, Deniz Bayrami and Ahmad Salimi Tags: Research Source Type: research
Prescription characteristics associated with drug overdose risk among adults prescribed benzodiazepines: a cohort study
Drug overdose (OD) deaths in the U.S. continue to rise. After opioids, benzodiazepines (BZD) are the medication most commonly involved in prescription overdoses, yet OD risk factors among those prescribed BZD ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 19, 2023 Category: Drugs & Pharmacology Authors: Donovan T. Maust, Amy S. B. Bohnert, Julie Strominger and Jason E. Goldstick Tags: Research article Source Type: research
Analysis of the relation between adverse events and overall survival in patients treated with pembrolizumab as a first-line treatment for metastatic NSCLC
Many trials supported pembrolizumab as a first-line monotherapy to significantly improve overall survival (OS) in selected patients with previously untreated metastatic Non –Small Cell Lung Cancer (mNSCLC) and ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 15, 2023 Category: Drugs & Pharmacology Authors: Lisa Faoro, Adriana Brusegan, Alberto Russi, Vincenzo Calderone, Alma Martelli, Ettore Marranconi, Debora Carpanese, Elena Berti and Marina Coppola Tags: Research article Source Type: research
β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder. The naturally occurring phytosterol; β-sitosterol has antiobesogenic and anti-diabetic properties. The purpose of this s... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 12, 2023 Category: Drugs & Pharmacology Authors: Omayma AR Abo-Zaid, Fatma SM Moawed, Effet Soliman Ismail and Mostafa A. Farrag Tags: Research Source Type: research
Antitumor effects of erlotinib in combination with berberine in A431 cells
First-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as erlotinib, have been shown to target tumors with L858R (exon 21) and exon 19 deletions, resulting in significan... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 11, 2023 Category: Drugs & Pharmacology Authors: Xiangdan Cuan, Xingying Yang, Weiwei Zhu, Yue Zhao, Rui Luo, Yanping Huang, Xuanjun Wang and Jun Sheng Tags: Research Source Type: research
In vitro anti-plasmodial activity of three selected medicinal plants that are used in local traditional medicine in Amhara region of Ethiopia
The plants Aloe weloensis, Lepidium sativum, and Lobelia gibberoa have been used in Ethiopian folklore medicine to treat various diseases including malaria. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 11, 2023 Category: Drugs & Pharmacology Authors: Yenesew Wudu Ejigu and Bedilu Linger Endalifer Tags: Research Source Type: research
Survivability of patients admitted for stroke in a primary stroke center, Penang, Malaysia: a retrospective 5-year study
Stroke is one of the most common noncommunicable diseases, with significant public health implications both globally and in Malaysia. The aim of this study was to evaluate post-stroke survivability as well as ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - May 2, 2023 Category: Drugs & Pharmacology Authors: Monica Danial, Nurul Shahira Izwani Mohdradzi, Amer Hayat Khan, Alan Swee Hock Ch ’ng and Looi Irene Tags: Research Source Type: research
Lupeol alleviates atopic dermatitis-like skin inflammation in 2,4-dinitrochlorobenzene/Dermatophagoides farinae extract-induced mice
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects from children to adults widely, presenting symptoms such as pruritus, erythema, scaling, and dryness. Lupeol, a pentacyclic triterpeno... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 25, 2023 Category: Drugs & Pharmacology Authors: Sojung Bae, Na-Hee Jeong, Young-Ae Choi, Byungheon Lee, Yong Hyun Jang, Soyoung Lee and Sang-Hyun Kim Tags: Research Source Type: research
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway
Medical therapies can cause cardiotoxicity. Chloroquine (QC) and hydroxychloroquine (HQC) are drugs used in the treatment of malaria and skin and rheumatic disorders. These drugs were considered to help treatm... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 21, 2023 Category: Drugs & Pharmacology Authors: Enayatollah Seydi, Mojgan Karbalay, Saghi Naderpour, Abdollah Arjmand and Jalal Pourahmad Tags: Research Source Type: research
Remifentanil but not sufentanil induces cardioprotection in human ischemic heart muscle in vitro
Previous studies on animal models have suggested that δ-opioid receptor (OR) signaling is the primary pathway responsible for opioids' cardioprotective effect. We hypothesize that the μ-OR's activation protect... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 20, 2023 Category: Drugs & Pharmacology Authors: Marcin Kunecki, Tomasz Oleksy, Jan Martyn ów, Michalina Zygmunt, Marek Deja, Tomasz Kargul, Jolanta Biernat, Piotr Podolec, Krzysztof S. Gołba and Wojciech Płazak Tags: Research Source Type: research
Effect of renin angiotensin blockers on angiotensin converting enzyme 2 level in cardiovascular patients
Renin –angiotensin–aldosterone system (RAAS) is hypothesized to be in the center of COVID pathophysiology as the angiotensin converting enzyme 2 (ACE2) represents the main entrance of the virus, thus there is a... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 14, 2023 Category: Drugs & Pharmacology Authors: Sarah Farid fahmy, Marwa Omar El Derany, Hazem Khorshid, Ayman Saleh and Ebtehal El-Demerdash Tags: Research Source Type: research
The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a systematic review and meta-analysis of randomized clinical trials
Standard doses of second-generation H1-antihistamines (sgAHs) as first-line treatment are not always effective in treating chronic spontaneous urticaria (CSU), and hence an increase in the dose of sgAHs is recomm... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 6, 2023 Category: Drugs & Pharmacology Authors: Xianjun Xiao, Peiwen Xue, Yunzhou Shi, Junpeng Yao, Wei Cao, Leixiao Zhang, Zihao Zou, Siyuan Zhou, Chuan Wang, Mingling Chen, Rongjiang Jin, Ying Li and Qianhua Zheng Tags: Research Source Type: research
Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases
Since the warnings by the United States (US) and European regulatory authorities in 2004 and 2005 it had been discussed whether there is some link between selective serotonin reuptake inhibitors (SSRIs) and su... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 31, 2023 Category: Drugs & Pharmacology Authors: Diana Dubrall, Stefanie Fekete, Sarah Leitzen, Lena Marie Paschke, Marcel Romanos, Matthias Schmid, Manfred Gerlach and Bernhardt Sachs Tags: Research Source Type: research
