The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice
Tacrolimus (Tac) is a common immunosuppressant that used in organ transplantation. However, its therapeutic index is narrow, and it is prone to adverse side effects, along with an increased risk of toxicity, n... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 28, 2022 Category: Drugs & Pharmacology Authors: Dadi Xie, Jinxiu Guo, Ruili Dang, Yanan Li, Qingying Si, Wenxiu Han, Shan Wang, Ning Wei, Junjun Meng and Linlin Wu Tags: Research Source Type: research

Human targeted phenobarbital presents a poor substrate of gut microbiome deciphering new drug targets beyond pharmacokinetic curbs
The gut microbiome, a new organ of the body, can potentially alter the pharmacokinetics of orally administered drugs through microbial enzymes. However, absorption of orally administered non-antibiotic drugs b... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 14, 2022 Category: Drugs & Pharmacology Authors: Imran Mukhtar, Haseeb Anwar, Arslan Iftikhar, Heba E. Hashem, Qasim Ali and Farhan Siddique Tags: Research Source Type: research

Factors associated with a basic common drug-drug interaction knowledge among emergency department medical personnel
Drug-drug interactions (DDIs) are common but less concerning in clinical practice of time-sensitive situations. We aimed to identify factors associated with a basic common DDI knowledge among an emergency phys... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 31, 2022 Category: Drugs & Pharmacology Authors: Theerapon Tangsuwanaruk and Borwon Wittayachamnankul Tags: Research Source Type: research

Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations
Toxicological problem associated with herbal medicine is a significant public health problem. Hence, it is necessary to elaborate on the safety of herbal medicine. Salvianolic acid A (SAA) is a major active co... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 26, 2022 Category: Drugs & Pharmacology Authors: Ming-Yan Yang, Ze-Yu Song, Hai-Lin Gan, Mei-Hua Zheng, Qian Liu, Xiang-Ting Meng, Tao Pan, Zhen-Yuan Li, Ruo-Xuan Peng, Ke Liu and Hua-Ying Fan Tags: Research Source Type: research

Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway
Ischemia stroke is the leading cause of disability, which is a consequence of vascular occlusion. The purpose of this study is to investigate the effect of cornin which is isolated from the fruit of Verbena of... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 24, 2022 Category: Drugs & Pharmacology Authors: Tianchi Lan, Yangyang Xu, Shucui Li, Ning Li, Shuping Zhang and Haibo Zhu Tags: Research Source Type: research

Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm
Vascular smooth muscle cell (VSMC) phenotypic modulation regulates the initiation and progression of intracranial aneurysm (IA). Dexmedetomidine (DEX) is suggested to play neuroprotective roles in patients wit... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 23, 2022 Category: Drugs & Pharmacology Authors: Ze Zhang, Xiue Mu and Xiaohui Zhou Tags: Research Source Type: research

Real life evaluation of the multi-organ effects of Lumacaftor/Ivacaftor on F508del homozygous cystic fibrosis patients
Lumacaftor/Ivacaftor (LUM-IVA), a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector-potentiator combination, improves lung function and reduces pulmonary exacerbations (PEx) in F508d... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 20, 2022 Category: Drugs & Pharmacology Authors: Karin Yaacoby-Bianu, Zeev Schnapp, Ilana Koren, Anat Ilivitzki, Mohamed Khatib, Nadeem Shorbaji, Michal Shteinberg and Galit Livnat Tags: Research Source Type: research

Predictors of acarbose therapeutic efficacy in newly diagnosed type 2 diabetes mellitus patients in China
Acarbose is one of the optimal drugs for patients with the first diagnosis of type 2 diabetes mellitus (T2DM). But what kind of emerging patients has the best therapeutic response to acarbose therapy has never... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 18, 2022 Category: Drugs & Pharmacology Authors: Rong Zhang, Quanxi Zhao and Rong Li Tags: Research article Source Type: research

Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium
Lactoferrin, an iron-binding glycoprotein, is known to have protective effects against intestinal and cerebral ischemia-reperfusion (IR) injuries; however, its cardioprotective effects against the stunned myoc... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 14, 2022 Category: Drugs & Pharmacology Authors: Keisuke Omiya, Yosuke Nakadate, Takeshi Oguchi, Tamaki Sato, Toru Matsuoka, Masako Abe, Akiko Kawakami, Takashi Matsukawa and Hiroaki Sato Tags: Research Source Type: research

Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation
Estrogen receptor β (ERβ) is the major ER subtype in hepatic stellate cells (HSCs). Previously we reported phytoestrogen calycosin suppressed liver fibrosis progression and inhibited HSC-T6 cell functions, sug... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 7, 2022 Category: Drugs & Pharmacology Authors: Yaxin Wang, Canyan Wu, Jiahui Zhou, Haiming Fang and Jiajia Wang Tags: Research Source Type: research

Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats ’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance
Inadvertent exposure to furan and Pb is associated with hepatorenal abnormalities in humans and animals. It is perceived that these two chemical species may work in synergy to orchestrate liver and kidney dama... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 1, 2022 Category: Drugs & Pharmacology Authors: Solomon E. Owumi, Uche O. Arunsi, Omolola M. Oyewumi and Ahmad Altayyar Tags: Research Source Type: research

Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation
Ischemia-reperfusion (I/R) of the liver is a multifactorial condition that happens during transplantation and surgery. The deleterious effects of I/R result from the acute production of reactive oxygen species... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 29, 2022 Category: Drugs & Pharmacology Authors: Hamidreza Totonchi, Pooneh Mokarram, Saeed Karima, Ramazan Rezaei, Sanaz Dastghaib, Farhad Koohpeyma, Shokoofe Noori and Negar Azarpira Tags: Research Source Type: research

β-Hydroxyphosphocarnitine modifies fibrosis, steatosis and improves liver function in non-alcoholic steatohepatitis induced in rats
Non-alcoholic steatohepatitis (NASH) is a chronic disease characterized by inflammation, steatosis, and liver fibrosis. The liver is particularly affected by alterations in lipid metabolism. Our aim was to eva... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 29, 2022 Category: Drugs & Pharmacology Authors: Janet S ánchez-Quevedo, Emmanuel Ocampo-Rodríguez, Elizabeth Alvarez-Ayala, Anahí Rodríguez-López, Miguel Angel Duarte-Vázquez, Jorge Luis Rosado and Lourdes Rodríguez-Fragoso Tags: Research Source Type: research

Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial
Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually relieve the severity of symptoms by as much as 20 –30%, and satisfactory treatment is obtained in 40–60% of pat... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 27, 2022 Category: Drugs & Pharmacology Authors: Ala Ghobadian, Saba Mokhtari, Behnam Shariati, Leila Kamalzadeh, Mohsen Shati, Mehrdad Eftekhar Ardebili, Masoomeh Yarahmadi and Mohammadreza Shalbafan Tags: Research Source Type: research

Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats
The Blood-Brain Barrier (BBB) is a filter for most medications and blocks their passage into the brain. More effective drug delivery strategies are urgently needed to transport medications into the brain. This... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - September 26, 2022 Category: Drugs & Pharmacology Authors: Heba M. Fahmy, Mostafa M. Ahmed, Ayman S. Mohamed, Engy Shams-Eldin, Taiseer M. Abd El-Daim, Amena S. El-Feky, Amira B. Mustafa, Mai W. Abd Alrahman, Faten F. Mohammed and Mohamed M. Fathy Tags: Research Source Type: research