Comparison of three different prophylactic treatments for postoperative nausea and vomiting after total joint arthroplasty under general anesthesia: a randomized clinical trial
This study was performed to evaluate the efficacy of three different prophylactic regimen... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 30, 2024 Category: Drugs & Pharmacology Authors: Jinwei Xie, Yingcun Cai and Fuxing Pei Tags: Research Source Type: research
Informal sale of antibiotics in Guatemalan convenience stores before and after implementation of federal antibiotic dispensing legislation
Convenience stores in Guatemala provide essential consumer goods in communities, but many dispense antibiotics illegally. Federal legislation, passed in August of 2019, requires prescriptions for antibiotic pu... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 25, 2024 Category: Drugs & Pharmacology Authors: N. Rojop, P. Moreno, L. Grajeda, J. Romero, L. Reynoso, E. Mu ñoz, G. H. Palmer, C. Cordón-Rosales, D. R. Call and B. M. Ramay Tags: Research Source Type: research
Lipidomics reveals serum lipid metabolism disorders in CTD-induced liver injury
Cantharidin (CTD), the main toxic component of Mylabris, has been extensively used for tumor treatment in recent years. CTD-induced liver toxicity has attracted significant interest in clinic. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 15, 2024 Category: Drugs & Pharmacology Authors: Shan Li, Xiaotong Duan, Yixin Zhang, Cancan Zhao, Ming Yu, Xiaofei Li, Xiaomei Li and Jianyong Zhang Tags: Research Source Type: research
Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice
The Gram-negative bacterium Helicobacter pylori, H. pylori, is associated with significant digestive disorders. However, the effectiveness of bacterial eradication is declining due to drug resistance. A potent an... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 11, 2024 Category: Drugs & Pharmacology Authors: Kiarash Ghazvini, Hossein Kamali, Hadi Farsiani, Masoud Yousefi and Masoud Keikha Tags: Research Source Type: research
Enoxaparin for VTE thromboprophylaxis during inpatient rehabilitation care: assessment of the standard fixed dosing regimen
We aimed to examine the efficiency of fixed daily dose enoxaparin (40 mg) thromboprophylaxis strategy for patients undergoing inpatient rehabilitation. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Authors: Amir Haim, Orli Avnery, Deborah Rubin-Asher, Hagay Amir, Kaifa Hashem, Harel Ben Zvi and Motti Ratmansky Tags: Research Source Type: research
Fenofibrate alleviates NAFLD by enhancing the PPAR α/PGC-1α signaling pathway coupling mitochondrial function
To comprehend the influences of fenofibrate on hepatic lipid accumulation and mitochondrial function-related signaling pathways in mice with non-alcoholic fatty liver disease (NAFLD) secondary to high-fat diet... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 3, 2024 Category: Drugs & Pharmacology Authors: Xuemei Wang, Jieying Wang, Cao Ying, Yuan Xing, Xuan Su and Ke Men Tags: Research Source Type: research
Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY ®) in healthy Chinese volunteers
Definity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as perflutren, microspheres, which is initially designed to enhance echocardiographic ultras... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Authors: Pengfei Li, Ping Du, Jun Peng, Zhixia Zhao, Huiling Li, Weiyue Yu, Shumin Wang and Lihong Liu Tags: Research Source Type: research
Genetic prediction of antihyperglycemic drug targets and risk of epilepsy: a mendelian randomisation study
A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unc... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Authors: Kaiping Zhou, Huan Yang, Zhihao Xie, Weiping Wang and Zhenzhen Qu Tags: Research Source Type: research
Prevalence and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city, southwestern Uganda
This study aimed to determine the prevalence, severit... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Authors: Allan Phillip Lule, Ogwal Basil Delic, Keneth Katunguka, Francis Muwonge and Tadele Mekuriya Yadesa Tags: Research Source Type: research
Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination
The objective ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Authors: Yu-Jie Liang, Ding-Xin Long, Shanshan Wang, Hui-Ping Wang and Yi-Jun Wu Tags: Research Source Type: research
Prediction of drug –drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach
This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to predict changes in the pharmacokinetics (PK) and pharmacodynamics (PD, PDE4 inhibition) of roflumilast (ROF) and ROF N-oxide ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Authors: Guangwei Jia, Congcong Ren, Hongyan Wang and Caixia Fan Tags: Research Source Type: research
Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Previous pharmacovigilance studies and a retroactive review of cancer clinical trial studies identified that women were more likely to experience drug adverse events (i.e., any unintended effects of medication... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Authors: Jennifer L. Fisher, Amanda D. Clark, Emma F. Jones and Brittany N. Lasseigne Tags: Research Source Type: research
Amlodipine alleviates renal ischemia/reperfusion injury in rats through Nrf2/Sestrin2/PGC-1 α/TFAM Pathway
Previously, observational studies showed that amlodipine can mitigate calcineurin inhibitor- and contrast-induced acute kidney injury (AKI). Herein, we aimed to measure the effect of amlodipine on renal ischem... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 21, 2023 Category: Drugs & Pharmacology Authors: Hadi Shirzad, Seyed Amin Mousavinezhad, Mohammad Panji and Moin Ala Tags: Research Source Type: research
In diabetic male Wistar rats, quercetin-conjugated superparamagnetic iron oxide nanoparticles have an effect on the SIRT1/p66Shc-mediated pathway related to cognitive impairment
Quercetin (QC) possesses a variety of health-promoting effects in pure and in conjugation with nanoparticles. Since the mRNA-SIRT1/p66Shc pathway and microRNAs (miRNAs) are implicated in the oxidative process,... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 21, 2023 Category: Drugs & Pharmacology Authors: Mahnaz Karami Chamgordani, Akram Bardestani, Shiva Ebrahimpour and Abolghasem Esmaeili Tags: Research Source Type: research
Addition of progesterone to feminizing gender-affirming hormone therapy in transgender individuals for breast development: a randomized controlled trial
Feminizing gender-affirming hormone therapy (GAHT) for transgender individuals traditionally includes estradiol and androgen deprivation. Research has demonstrated that breast size as a result of GAHT in trans... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Benthe A.M. Dijkman, Danithsia Helder, Lidewij S. Boogers, Noor C. Gieles, Jason O. van Heesewijk, Sjoerd te Slaa, Niels P.T.J. Liberton, Chantal M. Wiepjes, Christel J.M. de Blok, Martin den Heijer and Koen M.A. Dreijerink Tags: Study Protocol Source Type: research
