Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial
The study was designed to investigate effects of single intravenous injection of esketamine on the incidence of postpartum depression (PPD) after labor analgesia and explore the potential mechanisms. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 23, 2023 Category: Drugs & Pharmacology Authors: Bin Ling, Yun Zhu, Zelin Yan, Hao Chen, Hua Xu, Qi Wang, Wanyou Yu and Wei Wang Tags: Research Source Type: research
The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials
Dyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced levels of high-density lipoprotein (HDL), is a major risk factor for car... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 22, 2023 Category: Drugs & Pharmacology Authors: Mohsen Yousefi, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Samira Rastgoo, Reza Bagher, Alireza Khadem, Farideh Shiraseb and Omid Asbaghi Tags: Research Source Type: research
Study on the association between adverse drug reactions to opioids and gene polymorphisms: a case-case –control study
Adverse drug reactions (ADRs) caused by opioid drugs show individual differences. Our objective was to explore the association between gene polymorphism and ADRs induced by opioid drugs. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 21, 2023 Category: Drugs & Pharmacology Authors: Jing Yang, Ying-zi Sun, Qun-fang Li, Zheng Fu, Yu-yao Guan, Chao Song and Lei Zheng Tags: Research Source Type: research
Bisdemethoxycurcumin alleviates LPS-induced acute lung injury via activating AMPK α pathway
Inflammation and oxidative stress contribute to the pathogenesis of acute lung injury (ALI), and subsequently result in rapid deterioration in health. Considering the indispensable role of bisdemethoxycurcumin... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 20, 2023 Category: Drugs & Pharmacology Authors: Huifang Li, Qi Zou and Xueming Wang Tags: Research Source Type: research
A disproportionality analysis of adverse events associated to pertuzumab in the FDA Adverse Event Reporting System (FAERS)
Pertuzumab is widely used for the treatment of HER2 + breast cancer. But its safety in the real world should be continuously monitored. So, we evaluated the safety of pertuzumab by pharmacovigilance analyze ba... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 13, 2023 Category: Drugs & Pharmacology Authors: Shu-peng Zou, Hai-yun Yang, Meng-ling Ouyang, Qian Cheng, Xuan Shi and Ming-hui Sun Tags: Research Source Type: research
In vitro evaluation of cell viability and expression profile of growth factors in mouse Sertoli cells exposed to Delta-9-tetrahydrocannabinol: a mechanistic insight into the cannabinoid-induced testicular toxicity
The potentially adverse effects of cannabis (marijuana), a common leisure compound, on male reproductive performance are a reason for concern. δ-9-tetrahydrocannabinol (THC), the primary active component of ma... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: Shadi Mohammadpour-Asl, Shiva Roshan-Milani, Amin Abdollahzade Fard and Ali Golchin Tags: Research Source Type: research
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson ’s disease model
Parkinson ’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of nigrostriatal dopaminergic neurons and movement impairment. Based on theories, neuroinflammatory proces... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 7, 2023 Category: Drugs & Pharmacology Authors: Zahra Salari, Ghorbangol Ashabi, Ali Fartoosi, Ahmad Fartoosi, Marjan Shariatpanahi, Mehdi Aghsami, Hamed Montazeri and Afshin Kheradmand Tags: Research Source Type: research
Efficacy of intravenous N acetylcysteine as an adjuvant therapy in the treatment of acute aluminum phosphide Poisoning: a systematic review and meta-analysis
Aluminum phosphide toxicity is a serious problem in many countries. Unfortunately, there is no specific antidote. N-acetylcysteine has been used in some studies as adjuvant therapy depending on to its antioxid... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 3, 2023 Category: Drugs & Pharmacology Authors: Heba Othman Shaker, Omar El Sayed Rageh, Maged Alnajar, Nesreen Fares Alshamaly, Walaa Abdelfattah Abdelmaged and Mohamed Abd-ElGawad Tags: Research Source Type: research
GHB toxicokinetics and renal monocarboxylate transporter expression are influenced by the estrus cycle in rats
The illicit use and abuse of gamma-hydroxybutyric acid (GHB) occurs due to its sedative/hypnotic and euphoric effects. Currently, there are no clinically available therapies to treat GHB overdose, and care foc... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - November 2, 2023 Category: Drugs & Pharmacology Authors: Hao Wei, Jieyun Cao, Tyler Fallert, Su Yeo and Melanie A. Felmlee Tags: Research Source Type: research
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells
(Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 27, 2023 Category: Drugs & Pharmacology Authors: Jui-Ting Chang, Yao-Jen Liang, Chia-Yu Hsu, Chao-Yi Chen, Po-Jung Chen, Yi-Feng Yang, Yen-Lin Chen, Dee Pei, Jin-Biou Chang and Jyh-Gang Leu Tags: Correction Source Type: research
Oxidative stress induction by narasin augments doxorubicin ’s efficacy in osteosarcoma
Complications and fata toxicity induced by chemotherapy are the main challenge for clinical management of osteosarcoma. The identification of agents that can augment the efficacy of chemotherapy at lower doses... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 20, 2023 Category: Drugs & Pharmacology Authors: Zhaoming Han, Juguang Yang, Ping Wang, Feng Bian and Jiguang Jia Tags: Research Source Type: research
Correction: Core decompression combined with local DFO administration loaded on polylactic glycolic acid scaffolds for the treatment of osteonecrosis of the femoral head: a pilot study
(Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 17, 2023 Category: Drugs & Pharmacology Authors: Kaveh Gharanizadeh, Ali Mohammad Sharifi, Hamed Tayyebi, Razieh Heidari, Shayan Amiri and Sajad Noorigaravand Tags: Correction Source Type: research
Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
AT-533 is a novel heat shock protein 90 inhibitor that exerting anti-inflammatory, antiviral, and antitumor efficacy. Furthermore, the gel made of AT-533 as raw material named AT-533 gel has the function of re... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 13, 2023 Category: Drugs & Pharmacology Authors: Lishan Zhong, Yanting Wu, Chen Huang, Kaisheng Liu, Cui-fang Ye, Zhe Ren and Yifei Wang Tags: Research Source Type: research
Retraction Note: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
(Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 13, 2023 Category: Drugs & Pharmacology Authors: Omnia I. Ismail, Eman S. Shaltout, Nora Z. Abdellah, Diab F. Hetta, Wael M. A. Abd El-Ghani, Lobna A. Abdelzaher, Ahmed Mohamed Mohamed Mahmoud, Asmaa M. Hasan, Noha A. Rashed and Noha Esmael Ebrahem Tags: Retraction Note Source Type: research
Metformin alleviates adriamycin resistance of osteosarcoma by declining YY1 to inhibit MDR1 transcriptional activity
Chemotherapy resistance hinders the successful treatment of osteosarcoma (OS) to some extent. Previous studies have confirmed that metformin (Met) enhances apoptosis induced by chemotherapeutic drugs, but the ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 12, 2023 Category: Drugs & Pharmacology Authors: Bowen Wu, Peng Li, Eryue Qiu and Jian Chen Tags: Research Source Type: research
