What Is Ketosis Anyway?
The carb craze may be responsible for thrusting the term ketosis into the mainstream vernacular. Before that, it was a word you rarely heard outside of medicine. Before Dr. Atikins and the low carb evangelists came along, you could relegate ketosis to a power point slide in an occasional diabetes lecture and be done with it.
Now it seems like ketosis is the in-word with soccer moms and zone dieters alike. And, while its conceptual popularity has grown, there’s still a lot of misunderstanding floating around about what ketosis is and what it means for your body. Much like belly button ...
Source: The EMT Spot - November 9, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
High Blood Pressure and Erectile Dysfunction
Research confirms that high blood pressure and ED are closely linked. But did you know the majority of cases of ED are caused by hypertension? Keep reading to find out more.
Experts suggest that “hypertension is sometimes a standalone condition and sometimes it’s associated with other conditions, which also impact erectile dysfunction.”
According to the European Society of Cardiology, this likelihood is almost double in men with uncontrolled high blood pressure.
Long-term exposure to hypertension and elevated blood pressure damages the arterial wall. This leads to atherosclerosis and the narrowing of art...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
High Blood Pressure Can Lead to Kidney Damage
Conclusion
A potential outcome of hypertension is damage to blood vessels and organs such as the kidneys. In addition, a delay in receiving treatment increases the risk of waste fluid build-up, which elevates the chance of complications and, ultimately, renal failure.
If your doctor has diagnosed you with hypertension, you might be recommended adaptations to your lifestyle and medications. It’s vital to take prescription drugs as indicated and attend follow-ups as scheduled to check blood pressure.
References
“High Blood Pressure & Kidney Disease.” National Institute of Diabetes and Digestive and Kidney...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
Connecting IGF1 Signaling and Cellular Senescence
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Link: https://doi.org/10.3390/cells11203260 ...
Source: Fight Aging! - November 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Basic Functions of Abdominal Organs
Most EMT level providers are square on the primary function of the stomach. We can name several things our liver is doing for us and we get the whole kidney concept as well. But when we start drifting beyond the basics, the conversation can turn fuzzy.
OK … It’s been a little while since I studied this. What was the spleen doing again? Something about the immune system right? Oh, the Pancreas that produces Insulin doesn’t it? Or was that the gallbladder?
Fear not. I put together a handy reference for you. Here’s a list of all those abdominal organs for your review. Now you can sort your large...
Source: The EMT Spot - November 7, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Has Omics Data Taught Us About Dementia?
An enormous amount of biological data can now be obtained from any given study population, and at reasonable cost. The resulting databases have grown to become very large. The epigenome, transcriptome, proteome, metabolome, microbiome, and much more, are at the fingertips of every epidemiological researcher, at multiple time points, before and after interventions, and at different ages. It is easy enough to find differences in the data between more healthy subjects and patients suffering from one or more age-related conditions. It is a harder task to build upon that data in order to find useful therapies. Aging causes swee...
Source: Fight Aging! - November 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Growth Hormone Receptor Knockout in Adipose Tissue Extends Life in Mice
The record for mouse life span is held by growth hormone receptor knockout lineages, approaching a 70% gain, but a lot of that increase is due to early life effects. These animals are very small in comparison to their peers. In comparison, growth hormone receptor knockout in adulthood has a greater impact on female mice than on male mice, and the gain in life span is much reduced. In today's open access paper, researchers demonstrate another approach, generating a lineage of mice in which growth hormone receptor is only disabled in fat tissue. Again, the outcomes are different in male and female mice, and smaller than thos...
Source: Fight Aging! - November 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
On cognitive training, muscle mass, neurostimulation, brain teasers, apps, and more
Welcome to a new edition of SharpBrains’ e‑newsletter, featuring timely brain & innovation news and a few fun teasers to test your working memory.
#1. Study: Building muscle mass helps delay cognitive decline beyond the value of exercise itself
“Teasing out exactly how muscle helps the brain remains a challenge. There are plenty of indirect links … But Dr. Chevalier’s results suggest there may be more direct mechanisms too. One possibility is the role of myokines, a set of hormone-like molecules produced by muscle cells that can travel to the brain and influence mood, learning and other cognitive functions. G...
Source: SharpBrains - October 31, 2022 Category: Neuroscience Authors: SharpBrains Tags: Brain Teasers Brain/ Mental Health SharpBrains Monthly eNewsletter Technology & Innovation app ratings brain vitals cognitive decline cognitive profiles Cognitive-functions Cognitive-Training DANA brain vital digital mental health Source Type: blogs
Fight Aging! Newsletter, October 31st 2022
This study used mice to evaluate how their lifestyles - eating fatty foods vs. healthy and exercising vs. not - affected the metabolites of their offspring. Metabolites are substances made or used when the body breaks down food, drugs or chemicals, or its own fat or muscle tissue. "We have previously shown that maternal and paternal exercise improve health of offspring. Tissue and serum metabolites play a fundamental role in the health of an organism, but how parental exercise affects offspring tissue and serum metabolites has not yet been investigated."
Researchers used targeted metabolomics - the study of metaboli...
Source: Fight Aging! - October 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Age of Metabolomics
Obtaining enormous amounts of data on the human metabolome now costs little. Databases of metabolomic data available for analysis have become vast, and continue to grow. Productive analysis trails far behind the production of data, unfortunately, as is true for all of the omics technologies. In this paper, researchers discuss the present state of metabolomic knowledge in the context of aging, and the path forward to producing useful understanding from this deluge of human data, contributing perhaps to the better development of treatments for aging.
Aging is a fundamental part of the human experience, and it has lo...
Source: Fight Aging! - October 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Including Standardized Patients With Diverse Gender Identities in Simulation Cases
On this episode of the Academic Medicine Podcast, guests Luca Petrey and Laura Weingartner, PhD, MS, join hosts Toni Gallo and Research in Medical Education (RIME) Committee members Arianne Teherani, PhD, and Daniele Olveczky, MD, to discuss a new scoping review of the literature on the inclusion of standardized patient characters and actors with diverse gender identities in simulation cases.
This is the second episode in this year’s 3-part series of discussions with RIME authors about their medical education research and its implications for the field.
This episode is now available through Apple Podcast...
Source: Academic Medicine Blog - October 24, 2022 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast gender identity health equity medical education Research in Medical Education RIME simulation standardized patients Source Type: blogs
Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging.
HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes from the Rejuvenation Startup Summit, Held in Berlin in October 2022
We presented recent results showing reversal of liver inflammation and fibrosis in NASH model mice, and noted that we're raising funds to start our clinical development program leading to human trials. Therapies to reverse atherosclerosis progression will follow shortly on the heels of this work on NASH.
Robin Mansukhani of Deciduous Therapeutics discussed their approach to immune system modulation via small molecules, training invariant natural killer cells to attack senescent cells. The point was made that engaging the immune system may be a way to work around many of the present unknowns regarding senescent cell ...
Source: Fight Aging! - October 19, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
