Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Immune System Mediates Some of the Benefits of Exercise
It is uncontroversial to point out that exercise is good for long-term health. It slows aging, reduces risk of age-related disease, reduces mortality. A mountain of evidence supports these assertions, both animal studies demonstrating causation, and any number of large human studies showing correlation. Exercise, like the practice of calorie restriction, produces sweeping changes in the operation of metabolism. Near everything is different, both in the short term following exercise, and over the long term when looking at differences between the biochemistry of a fit individual versus that a sedentary individual. This can m...
Source: Fight Aging! - November 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Specific Gut Bacteria Influence Oxytocin Levels
Circulating oxytocin levels decline with age, and a number of research groups have demonstrated that oxytocin upregulation produces benefits in animal studies. Here, researchers provide evidence for a species of bacteria resident in the intestine to contribute to changes in oxytocin expression and secretion. As the balance of different microbial populations of the gut change with age, this might lead to ways to restore more youthful levels of oxytocin in the body via manipulation of the gut microbiome.
The gut microbiome, a community of trillions of microbes living in the human intestines, has an increasing reputa...
Source: Fight Aging! - November 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Role of Senescent Cells in Age-Related Skeletal Diseases
Compelling evidence obtained from many studies in mice show that the accumulation of senescent cells with age is a major contributing factor in all of the common, inflammatory age-related conditions: cardiovascular disease, dementia, degeneration of bone tissue, and so forth. Senescent cells are created throughout life, mostly as somatic cells reach the Hayflick limit on replication, but accumulate in later life in large part because the immune system falters in its clearance of senescent cells. It still performs this function, but less efficiently, and the balance between creation and destruction of senescent cells tips t...
Source: Fight Aging! - November 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Joanna Strober, CEO, Midi Health
Women’s health in their mid-life has been very poorly treated. No one has been managing all of women’s health, and almost no one has been delivering hormone replacement therapy since a now debunked 2002 study. Midi is a new company with protocols for many conditions, and it has been training NPs to deliver the care (because no one has been training them!). CEO Joanna Strober explained how Midi is providing care in 14 states now and will be in all 50 next year, and how Midi is delivering virtual and comprehensive care to women–many of whom do not have access to any other type of regular care. They just rai...
Source: The Health Care Blog - November 6, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Medical Practice Joanna Strober Matthew Holt Midi Health Women's Health Source Type: blogs
Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
...
Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Anabolic Resistance in Sarcopenia
Anabolic resistance is a description of a state, not a starting point for a therapy. Anabolism is the metabolism of growth and repair, and in a state of anabolic resistance cells become less responsive to the signaling environment that normally encourages growth and repair. If the goal is therapies, then why this anabolic resistance occurs becomes the question. Muscles lose mass and strength with age, leading to the condition called sarcopenia. This, obviously, must involve anabolic resistance, and here researchers discuss what is known of this view of the sarcopenia of old age.
The development of sarcopenia in th...
Source: Fight Aging! - November 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The hypoglycemia fear syndrome
In this episode of BDI Briefs, we dive into causes, symptoms, and strategies for managing fear of hypoglycemia for people with type 1 and type 2 diabetes.Learn about the Be Safe and Feel Safe strategies, the importance of diabetes technology, and how to regain confidence in blood sugar management.Polonsky, W. H., Guzman, S. J., & Fisher, L. (2023). The Hypoglycemic Fear Syndrome: Understanding and Addressing This Common Clinical Problem in Adults With Diabetes. Clinical diabetes : a publication of the American Diabetes Association, 41(4), 502–509. https://doi.org/10.2337/cd22-0131
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Source: Scott's Diabetes Blog - October 30, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sex Differences in Cholinergic Neurons in the Context of Alzheimer's Disease
Why are most Alzheimer's disease patients women? The longer female life expectancy is not enough to explain all of this difference, so researchers investigate the underlying biochemical differences between sexes in search of an explanation. The goal is to use this difference in outcomes to identify mechanisms that are important to disease progression in all humans. One might look at a recent paper on microglial biochemistry, for example, and compare with this examination of the activity of cholinergic neurons. It is worth noting that the two are linked, with cholinergic neurons likely regulating microglial behavior to some...
Source: Fight Aging! - October 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How Do Medicines Work?
Credit: iStock.
What we put into our bodies can affect how they function and what they do. For example, a sugary snack will probably make you feel differently than a high-protein meal. Similarly, different medicines elicit different responses in your body, and pharmacologists try to fine-tune each medicine to balance the desired (on-target) with the undesired (off-target) effects—a branch of pharmacology called pharmacodynamics.
Most medicines work by binding to a molecular target, usually proteins like receptors or enzymes, and either blocking or supporting its activity, which results in their therapeutic effects.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 16, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Source Type: blogs
Midi Health Raises $25M in Series A Funding Led by GV (Google Ventures) to Expand Access to Expert and Affordable Midlife Care for Women
The Leading Virtual Clinic Delivering Insurance-Covered, Expert Care for Women Perimenopause and Menopause, Midi Health Plans Major Expansion of National Footprint
Midi Health, the emerging digital leader in women’s midlife healthcare, today announced the close of a $25M Series A funding round led by GV (Google Ventures). Investors Frederique Dame and Cathy Friedman from GV are joined by current investors Felicis, Semper Virens, Icon, 25M, and Operator Collective, bringing the company’s total funding raised to date to $40M.
In the year since the company officially launched to consumers, Midi Health has...
Source: EMR and HIPAA - October 16, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 25M Cathy Friedman Felicis Frederique Dame Google Ventures GV Health IT Funding Health IT Fundings Health IT Investment ICON Joanna Strober Midi Health Operator Collective Semper Virens Source Type: blogs
The Mindful Body argues against mindlessly accepting age-related decline in cognition and health as inevitable
In 1979, Harvard researcher Ellen Langer invited elderly men to spend a week at a retreat designed to remind them of their younger days, surrounded by the art, music, food, games, décor, and more from the late 1950s. Afterward, the men were tested and found to have made significant gains in hearing, memory, dexterity, posture, and general well-being. It was as if being in a place signaling their younger days made them physiologically “younger.”
Maybe you, too, have had an experience where your mind seemed to affect your health. It turns out there’s a reason for that, according to Langer, author of the new book The M...
Source: SharpBrains - October 9, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning anti-anxiety medication anti-depressants book cognition cognitive change cognitive-abilities Ellen Langer mind mindfulness-meditation mindlessly physiology placebo studies Th Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aging Rate Indicators as Speedometers for Aging Research
Is it possible to measure the pace of aging at any given moment? Are there biomarkers that reveal not the biological age of the individual, but rather how fast that biological age is changing? The field is presently focused on developing measures of biological age, such as the extensive work on epigenetic clocks. Some information about pace of aging might be inferred from whether biological age is higher or lower than chronological age, assuming a biological age measurement that is actually accurate, something that still a topic for contention. But that doesn't say anything about the momentary pace of aging at any given ti...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
