The Interaction Between Metabolism and Stem Cell Aging
In today's open access paper, researchers discuss the influence of metabolism on the aging of stem cells. Stem cells maintain tissue by providing a supply of daughter somatic cells to replace losses. Animals have evolved to minimize the risk of cancer by limiting the ability of near all cells to replicate. Somatic cells operate under the Hayflick limit, driven by loss of telomere length with each cell division, leading to senescence or self-destruction when telomeres are short. Stem cells use telomerase to maintain long telomeres and thus continually produce replacement somatic cells with long telomeres.
Unfortunate...
Source: Fight Aging! - March 17, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A mother ’s early life experiences of adversity can influence her baby’s sensitivity to stress
By Emma Young
Over the past few decades, it’s become clear that experiences even before birth influence later psychological wellbeing. A mother’s stress levels during pregnancy have emerged as a key influence. Greater stress seems to programme her child to “expect” a difficult environment, and so to be more sensitive to potential threats — and more vulnerable to developing an anxiety disorder. It’s uncertain, though, whether adversity earlier in life affects stress levels during pregnancy, and so might impact the child’s sensitivity to stress. So Cassandra L. Hendrix at New York University and col...
Source: BPS RESEARCH DIGEST - March 15, 2022 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Babies Emotion Source Type: blogs
Digesting Foods and Fads - A Chat with Judi Nath | TAPP 111
AuthorJudi Nath stops by once more for a chat about another of her new books, this one titledDigesting Foods and Fads. We discuss the book'scontent, why Judi wrote it, and how we canuse the book's content to become better teachers of human anatomy& physiology.00:00 | Introduction00:42 | Introducing Judi Nath03:56 | Sponsored by AAA03:12 | Digesting Food and Fads18:11 | Sponsored by HAPI19:00 | Stories for Learning29:14 | Sponsored by HAPS30:21 | Million Dollar Words Explained39:13 | Staying Connected★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-episode-111.html🏅 ...
Source: The A and P Professor - March 14, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying reasons that appear to involve gene expression changes that reduce the effectiveness of mitochondrial quality control mechanisms. This has profound effects on tissue function throughout the body, and is an important contribution to degenerative aging. Here, researchers discuss some of the effects on fat tissue specifically.
Researchers looked at the role of age and physical training in mainta...
Source: Fight Aging! - February 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Against Testosterone Treatments for Older People
This cutting opinion piece is written in opposition to the prevalence of testosterone therapy, offered in many cases with the (dubious) promise of it being a way to push back the advance of aging. Hormone therapies in general are not to be taken lightly, but are widely used. Anyone should be free to try whatever they feel may work for them, but this approach may not be justified for most people given the balance of risk and benefit. That isn't a justification for restriction of personal freedom, but rather for greater efforts to educate in the face of overly enthusiastic marketing.
It is not easy in the present en...
Source: Fight Aging! - February 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A 40-something without past history presents with wide complex tachycardia and crushing chest pain
See Ken Grauer ' s important and detailed ECG analysis at the bottom.CaseA 40-something with no PMH presented with palpitations, tachycardia, and crushing chest pain.This was the prehospital ECG.Sustained wide complex tachycardia. Is it VT or SVT with Aberrancy?Also: there is no concordant ST segments or clearly excessively discordant ST segments, so superimposed Occlusion MI (OMI) is unlikely.There is a regular wide complex tachycardia, without P-waves, and anLBBB configuration andinferior axis. [LBBB "configuration" is different from LBBB: it means that there is a predominant S-wave in V1 and V2 and...
Source: Dr. Smith's ECG Blog - February 14, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs
Q & A with Dr. Wendy Suzuki on the parasympathetic nervous system and harnessing anxiety for good
Anxiety can feel like a heavy weight that we didn’t ask to carry. Who wouldn’t love to get rid of it?
But neuroscientist Wendy Suzuki wants to challenge the way we look at our anxiety. In fact, her new book is called Good Anxiety: Harnessing the Power of the Most Misunderstood Emotion.
If you’re skeptical, so was I. But Suzuki’s point is that anxiety is a natural human emotion, one that evolved to serve a purpose. We feel anxious when there is some kind of danger; it primes our body to fight or flee from that danger, in hopes that we’ll end up better off (i.e., alive). In the same way, our modern anxieties can be...
Source: SharpBrains - February 7, 2022 Category: Neuroscience Authors: Greater Good Science Center Tags: Education & Lifelong Learning anxiety chronic-stress deep breathing hippocampus human emotion neuroscientist parasympathetic nervous system prefrontal-cortex Stress Response uncertainty Source Type: blogs
Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity.
This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Considering the Longevity of Eusocial Insect Queens
Eusocial species are characterized by reproductive and non-reproductive castes, such as the familiar division of queens and workers in common insect species. Eusociality is more common in insects and less so in other classes of life, although there are a few eusocial mammals, such as the naked mole-rat. For researchers who investigate the comparative biology of aging, one of the more interesting aspects of eusociality is that queens live longer than workers, many times longer in some species, while being genetically identical. Why is this?
Comparing very similar species with divergent life spans is a desirable start...
Source: Fight Aging! - February 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
First Xenotransplantation of Engineered Porcine Organs to Human Patients
Sourcing organs from genetically engineered pigs is one of the options under development for the production of organs on demand for patients who need transplants. Ethically, growing organs from cells would be a better option, but we live in a world in which animals are widely seen only as tools to be used and consumed; one might hope that our descendants will grow to be better than us in that regard. Major surgery is a high risk undertaking in older people, and the best of all options would be to find ways to spur controlled regrowth and repair in native tissues. That remains more of an aspirational goal at this point, and...
Source: Fight Aging! - February 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Imperfectly Regrowing a Frog Limb Using Growth Factors to Change Cell Behavior
Researchers here report on a promising advance in making a non-regenerative species more regenerative. In recent years, research has focused on differences in the behavior of macrophages and injury-induced senescent cells in those species capable of regeneration of organs. It is presently thought likely that the capability for regeneration of organs exists in all higher animals, but it is in some way suppressed after embryonic development. Thus suitable coercion of cell behavior may unlock this ability. In this case, applying a combination of growth factors and other compounds for a short period of time sufficiently change...
Source: Fight Aging! - February 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction.
Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice
https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/
Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning a...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Popular Science Overview of the State of Development for Epigenetic Clocks
The development of rejuvenation therapies is haphazard and inefficient in part because measuring rejuvenation is costly, uncertain, and slow. On the one hand, rigorous and convincing data is needed to persuade conservative, risk-averse regulators and sources of funding to support work on rejuvenation at all. Further, cost-effective early guidance on whether one approach is better or worse than another is needed in to order to avoid a great deal of effort directed towards programs that cannot produce sizable outcomes for health.
With this in mind, the research community is in search of a way to rapidly assess biologi...
Source: Fight Aging! - January 28, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
