Adult Disruption of Growth Hormone Receptor in Mice Produces Improved Health and Longevity
Genetic engineering of mouse lineages to produce life-long disruption of growth hormone metabolism, either growth hormone itself or growth hormone receptor, extends life. Animals are smaller, more challenged in maintaining body temperature, have more fat tissue, yet enhanced insulin sensitivity, and exhibit as much as a 70% longer life span. The present record for engineered mouse longevity has been held since 2003 by growth hormone receptor knockout (GHRKO) mice. That this record still stands in 2021 might be taken as a sign that the research and development community are not yet trying hard enough to produce therapies ca...
Source: Fight Aging! - December 2, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Women Are No More Emotionally Turbulent Than Men
By Emily Reynolds
Women are commonly assumed to be more emotionally turbulent than men: moodier, more volatile, and more likely to experience rapid changes in affect across the course of the menstrual cycle. Aside from being the basis of many a sexist joke, this assumption has had an impact on research, with cisgender women excluded from research due to apparent fluctuations in mood.
Building on research exploring fluctuations in rodents, a team from the University of Michigan has looked more closely at such variability in humans. Their study in Scientific Reports finds no difference in emotional variance between ci...
Source: BPS RESEARCH DIGEST - December 2, 2021 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Emotion Sex Source Type: blogs
Results from a Trial of the Senolytic Fisetin in a Single Individual with Autoimmunity
Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
Source: Fight Aging! - November 30, 2021 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Narrow Window for Exercise to Improve Neurogenesis via Growth Hormone in Aged Mice
There is mixed evidence for exercise to improve neurogenesis and cognitive function in very old mice. Researchers here suggest that this is because the duration of an exercise program matters greatly, and there is a comparatively narrow window of time in which the result is a net gain in function. This may be an example of the frailty of old age: mild stresses such as exercise that are robustly beneficial in younger individuals become more of a balancing act between cost and benefit in age-damaged individuals. The results are interesting, and will likely guide further explorations of the effects of exercise in very old hum...
Source: Fight Aging! - November 24, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Considering Mechanistic Links Between Vascular Calcification and Osteoporosis
With advancing age, regulatory pathways involved in bone remodeling are activated inappropriately in smooth muscle cells of blood vessel walls and cardiac tissue. The result is calcification of tissue, making it inflexible, and disrupting the normal elasticity. That leads to hypertension and other, worse cardiovascular issues. Inflammatory signaling and the presence of senescent cells appear to be involved in causing this process, but firmly proven chains of cause and effect are yet to be established, as is the case for all too much of the panoply of dysfunctions that arise in the progression of degenerative aging.
...
Source: Fight Aging! - November 23, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Toothache, incidental Wide Complex Tachycardia
Discussion by our ElectrophysiologistSmith: “I thought that the wide complex tachy (WCT) could be AVRT or VT” EP: " Antidromic AVRT morphology would essentially be the same as “VT” originating from ventricular the insertion site of the accessory pathway. Therefore, traditional criteria for SVT with aberrancy do not apply to antidromic AVRT (except, that negative concordance can never be AVRT!) " Smith: “But then when the patient converted and had PVCs of exactly the same morphology as the WCT, that it must be VT and not AVRT ” EP: " In cases of intermittent pre-excitation, you cou...
Source: Dr. Smith's ECG Blog - November 17, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Woman ’ s Health Startup Pollie Wins Bayer G4A ’ s Attention With Female-Focused Chronic Condition Play
By JESSICA DaMASSA, WTF HEALTH
Forget being pigeon-holed as a “femtech” company! VERY early-stage women’s health startup, Pollie, is taking an integrated care approach to complex chronic conditions that either just affect women, OR impact women differently or disproportionally than men. Think not only about conditions caused by hormone imbalances like PCOS (polycystic ovarian syndrome) or endometriosis, but also auto-immune disorders and digestive disorders that present differently or more frequently in women.
Co-Founder and CEO, Jane Sagui, drops by to talk us through the platform Pollie is building (and I mea...
Source: The Health Care Blog - November 5, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology Jessica DaMassa WTF Health Chronic conditions chronic disease management femtech Jane Sagui Pollie woman's health Women's Health Source Type: blogs
Fight Aging! Newsletter, October 25th 2021
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx.
A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports
https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/
Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medic...
Source: Fight Aging! - October 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Latest Defiant Health podcast: The Magic of Oxytocin
While many call the hormone oxytocin “the love hormone” due to its effects on enhancing feelings of affection and closeness to other people, we could also call it “the hormone of youthfulness.” Boosting oxytocin blood levels yield effects such as smoother skin with reduced wrinkles, accelerated healing, restoration of youthful muscle and strength, deeper sleep with vivid dreams, and preservation of bone density—all markers of youthfulness.
Increasing oxytocin has, until recently, been problematic, as injectable forms last only 3 minutes, while intranasal delivery lasts only around 90 minutes.
...
Source: Wheat Belly Blog - October 22, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open anti-aging microbiota oxytocin probiotic Source Type: blogs
Machine Learning Can Make Lab Testing More Precise
An analysis of over 2 billion lab test results suggests a deep learning model can help create personalized reference ranges, which in turn would enable clinicians to monitor health and disease better.Paul Cerrato, MA, senior research analyst and communications specialist, Mayo Clinic Platform and John Halamka, M.D., president, Mayo Clinic Platform, wrote this article.Almost every patient has blood drawn to measure a variety of metabolic markers. Typically, test results come back as a numeric or text value accompanied by a reference range which represents normal values. If total serum cholesterol level is below 200 mg/dl or...
Source: Life as a Healthcare CIO - October 21, 2021 Category: Information Technology Source Type: blogs
Calorie Restriction versus Cancer, Viewed in Terms of Growth Signaling
The practice of calorie restriction, eating fewer calories while still obtaining sufficient micronutrients, is well demonstrated to reduce cancer risk in animal models, and also appears to improve outcomes in the case of an established cancer. This is similarly the case for practices such as intermittent fasting or fasting mimicking diets, the latter having undergone trials as an adjuvant therapy in human cancer patients. Researchers here review this topic through the lens of nutrient sensing and growth signaling in the body, such as the well studied pathways involving growth hormone and IGF-1. More growth means more DNA d...
Source: Fight Aging! - October 18, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards a Small Molecule Approach to Thymic Regeneration
The thymus is vital to a sustained and functional immune system. Thymocytes generated in the bone marrow migrate to the thymus, where a complex process of maturation and selection takes place, turning the thymocytes into T cells of the adaptive immune system. T cells must be capable of recognizing and reacting to pathogens and cancerous cells, without mistakenly attacking any of the normal systems of the body and its diverse cell population. That risk of self-immunity is the price of an adaptive immune system. The wide range of autoimmune conditions observed in the human population demonstrates that evolution does not prod...
Source: Fight Aging! - October 15, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Jekyll And Hyde Emotion? Research On Anger, Digested
This study provided evidence of “the important role of anger in the psychological process underlying moral courage,” the team wrote. Of course, a person’s individual moral framework is crucial here, though. If the sight of women venturing outdoors alone or going to work, say, deeply offends you, then your resulting outrage will likely propel you to action, too.
Expressing anger can also make you seem more authentic and sincere. At least, this was suggested by a 2021 study of Kickstarter pitch videos. Entrepreneurs are often encouraged to be only positive about their ventures, commented the researchers. But they fo...
Source: BPS RESEARCH DIGEST - October 12, 2021 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Anger Source Type: blogs
