Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What is Known of the Contribution of Cellular Senescence to Osteoporosis
The vast majority of senescent cells are produced when somatic cells reach the Hayflick limit to cell division, their telomeres shortened to a point at which they either self-destruct or enter the senescent state. Damage due to mutation or cytotoxic compounds can also induce senescence, as can the regenerative processes following injury. Senescent cells cease replication, become larger, and change their behavior in many other ways. Senescent cells secrete a pro-growth, pro-inflammatory mix of signals, the senescence-associated secretory phenotype (SASP), that attracts the attention of immune cells capable of destroying sen...
Source: Fight Aging! - March 1, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Amie Fornah Sankoh Achieves a Scientific Dream
Credit: LinkedIn.
“I wanted to give up so many times. Although I tried to remain positive, I never thought I’d be able to finish my Ph.D. But I made it, and I’m extremely proud of myself,” says Amie Fornah Sankoh, Ph.D., a research scientist with Dow Chemical Company who received NIGMS support as a graduate student.
Human and Plant Communication
Dr. Sankoh has loved science and mathematics since she was just a child growing up in Sierra Leone. When she was 3 years old, Dr. Sankoh became deaf from a childhood disease. Math, unlike other subjects, is very visual, which played a part in her interest in it. “...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 28, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Training Source Type: blogs
Digital Health, Menopause, And The $150 Billion Ignorance
The idea of this story came from personal experience. During the past year, I have spent countless hours and a bucketload of money trying to figure out what the heck is wrong with my health. I was feeling worse and worse, having various symptoms, totally inexplicable with my impeccable test results. During this journey, not a single doctor asked or suggested that my symptoms may come from entering perimenopause – the stage of life of women preceding menopause.
I am 47 years old, and as I have learned since then, extremely average in starting to have perimenopause symptoms at the age of 47. Also very average ...
Source: The Medical Futurist - February 22, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Lifestyle medicine female health menopause tech Source Type: blogs
Fight Aging! Newsletter, February 19th 2024
This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples. Spearman's correlation analysis was used to identify the potential serum and fecal metabolites associated with HGS.
We assessed the levels of serum and fecal metabolites belonging to...
Source: Fight Aging! - February 18, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cool Images: Radiant in Red
Happy Valentine’s Day! In place of red roses, we hope you’ll accept a bouquet of beautiful scientific images featuring rich, red hues. Be sure to click all the way through to see the festive protein flowing through your blood!
For more scientific photos, illustrations, and videos in all the colors of the rainbow, visit our image and video gallery.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 14, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Molecular Structures Cellular Imaging Cool Images Proteins Source Type: blogs
Allostatic Load as a Correlate of Aging
Allostatic load is the concept of wear and tear on the body that emerges from stresses via overactivation of the neuroendocrine system. Causative stresses can range from starvation to psychological stress to a high burden of age-related dysfunction. At some point reactions to stress that are compensatory tip over into being themselves damaging. Thus one could expect allostatic load to correlate with degenerative aging and risk of mortality to at least some degree. In practice, however, there is little agreement on how to measure allostatic load, particularly in human patients, which makes it hard to compare results from st...
Source: Fight Aging! - February 14, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DEL-1 Upregulation Promotes Bone Regeneration in Aged Mice
Bone is constantly remodeled throughout life. The extracellular matrix making up bone tissue is continually broken down by osteoclast cells and built up by osteoblast cells. In youth, these activities are balanced. With aging, however, the activity of osteoclast cells progressively outweighs the activity of osteoblast cells. The consequence is an ever greater loss of bone mineral density leading to osteoporosis. This process is also found in the bone loss characteristic of advanced periodontitis. There are many contributing factors leading to the imbalance in bone remodeling, and it isn't all that clear as to which of them...
Source: Fight Aging! - February 1, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Wrong lessons in lipidology : Eradicating LDL is not our goal !
15 % of body weight is fat. (10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand fat, lipid and cholesterol are different entities. LDL is obviously a target against atherosclerosis. While the total body fat seems to do little in determining blood cholesterol levels, what is more scientifically shocking is the slope of curve between blood LDL levels and plaque burden is rarely linear. Mind you, LDL constitutes .000025% of total fat. We have many other targets in dyslipidemia like free cholesterol, harmful fatty acids, remnant cholesterol, TGLs, dysfunctional HDLs
LDL is not innocen...
Source: Dr.S.Venkatesan MD - January 9, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized cut off value for ldl esc aha guidlines for lipids functions of ldl molecule good and bad cholesterol how low ldl can go inclisiron lipid metabolism lipidology pcsk inhibitors repatha Source Type: blogs
How Can the Immune System Go Awry?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
The immune system is designed to closely monitor the body for signs of intruders that may cause infection. But what happens if it malfunctions? Overactive and underactive immune systems can both have negative effects on your health.
Autoimmune Disorders
To effectively monitor the body for pathogens, the adaptive immune system has to learn what a pathogen “looks like” on a molecular level. During their development, white blood cells go through training to learn how to differe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Injury and Illness Diseases Immunology Miniseries Infectious Diseases Microbes Sepsis Source Type: blogs
Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in the Aging and Dysfunction of Skin
A great deal of research and development effort is now focused on finding ways to reduce the contribution of senescent cells to degenerative aging. Initiatives range from fundamental research into the biochemistry of senescent cells to clinical trials of early senolytic therapies capable of selectively destroying senescent cells. A growing burden of senescent cells is a feature of all organs and tissues in the body, the skin included. Researchers here discuss what is known of the role of cellular senescence in aging and dysfunction of skin, and what might be done about it.
The skin is the largest organ of the huma...
Source: Fight Aging! - January 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
CD38 in Ovarian Aging
The ovaries, like the thymus, are interesting for their comparatively early exhibition of age-related degeneration. Is there anything useful that can be learned about aging more generally by looking at the portions of the body that experience aging more rapidly? That remains to be seen. Here, researchers investigate NAD+ metabolism in the ovaries versus other tissues, noting that CD38, an enzyme that removes NAD+, is more active earlier in life. Approaches to maintain NAD+ levels slow ovarian aging, including knocking out CD38.
Delayed childbearing is prevalent worldwide, and ovarian senescence occurs earlier than...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
