You need to ask these questions to teens starting hormone therapy
In medical practice today, we have all types of providers in charge of birth control counseling and treatment: medical doctors, nurse practitioners, registered nurses, licensed vocational nurses, and even medical assistants who report to their licensed providers. Having a standardized questionnaire that all providers can easily use and incorporate into their practice would help safeguard
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You need to ask these questions to teens starting hormone therapy originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 17, 2022 Category: General Medicine Authors: Maria Mba Wright, MD and Carol Reavis, RN Tags: Conditions Primary Care Source Type: blogs
Evidence for Hypertension to Lead to Earlier Onset of Osteoporosis
Researchers here provide evidence for the raised blood pressure of hypertension to accelerate the progression of osteoporosis, the loss of bone density characteristic of old age, leading to an earlier onset of the condition. They speculate that inflammation is the mechanism of interest, based on the differences in outcome following induced hypertension in old mice, already suffering the inflammation of aging, versus induced hypertension in young mice. There are already many good reasons to work to minimize both chronic inflammation and any increase in blood pressure with age; more evidence for just how bad these aspects of...
Source: Fight Aging! - September 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
“ The social ” – a brief look at family
Our most important relationships, the ones we learn most from, probably occur in families (Bowlby, 1978). As kids, even before we begin to speak, we observe our family members – and there’s reasonable evidence showing that how well these early relationships develop influences our experience of pain and how we express it.
I had the occasion to read a little about adolescent and children’s pain, and the influence of parents on young people as they grow up. There’s a great deal of research interest in children’s pain because children with persistent pain grow up to be adults – usually al...
Source: HealthSkills Weblog - September 11, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Back pain Chronic pain Low back pain Research Science in practice adolescents biopsychosocial family pain management partners spouse Source Type: blogs
Fight Aging! Newsletter, September 12th 2022
Discussion of Present Drug Development to Target Senescent Cells
Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy
Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome
Arguing for an Expansion of the Hallmarks of Aging
https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/
The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. Thi...
Source: Fight Aging! - September 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Germline Stem Cells in Ovaries and Female Reproductive Aging
In today's open access paper, researchers discuss the evidence for the existence of germline stem cells in the ovaries, responsible for maintaining fertility in the usual manner of stem cells, by generating daughter cells that replace losses and ensure function. Is ovarian aging, leading into age-related infertility, much accelerated over the aging of other organs in our species because this stem cell population loses function more rapidly than those in other tissues? That is a reasonable hypothesis, and some of the possible mechanisms are discussed. That overies are a hypoxic environment to begin with, and that supply of ...
Source: Fight Aging! - September 6, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH.
First Generation Stem Cell Therapies Remain Comparatively Poorly Understood
https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/
We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metabolic Changes in Aging Humans
Within a species, variations in the operation of metabolism correlate with later life health and life span. Insulin metabolism is one of the more prominent and well studied examples. Much of this may stem from the lifestyle choices that epidemiology shows explain the majority of the variation in human life expectancy. Become sedentary or overweight and this pushes metabolism into a less optimal, more harmful state. The consequences to health and risk of mortality accrue over a long period of time, but are no less real for it.
The study of aging has long been linked with the study of metabolism, as early theories p...
Source: Fight Aging! - August 26, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Lilly Pulls the Plug on Mix-and-Inject Glugagon Rescue Kits
For those who didn ' t hear the news when it broke, diaTribe news reported (seehttps://diatribe.org/glucagon-options-expand-lilly-discontinues-emergency-kit for the news) that Lilly announced that the company intends to discontinue manufacturing its traditional Glucagon Emergency Kitshttps://www.lillyglucagon.com/ by the end of 2022. The kits are old-school, mix& inject kits that many patients (and caregivers alike) really despise because they are rather cumbersome and inconvenient to use when time is of the essence. Having an unpopular product works in the absence of competition, but when newer, more convenient produc...
Source: Scott's Web Log - August 17, 2022 Category: Endocrinology Tags: Eli Lilly and Company glucagon PBM rebates Source Type: blogs
Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pace of Life and and the Longevity Resulting From Growth Hormone Deficiency in Mice
The longest lived mice to date are those in which growth hormone signaling is disrupted, such as via growth hormone receptor knockout. While larger species tend to be longer lived, within a given mammalian species greater body size (and thus greater growth hormone activity) appears to reduce life expectancy. The effect is much more pronounced in short-lived species such as mice than in long-lived species such as our own, however. An inherited loss of function mutation in growth hormone receptor in humans produces Laron syndrome in a small population, but these individuals do not appear to live any longer than the rest of u...
Source: Fight Aging! - August 12, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Government Is the Scourge of Diabetics, Not Their Savior
Michael F. CannonCongressional Republicans have defeated a proposal by congressional Democrats to mandate that private insurance companies cap out ‐of‐pocket spending on insulin by their enrollees at $35 per month. Republicans were right to do so. Government is already driving insulin prices sky‐high. Further intervention would make matters worse.Diabetics need insulin to live. Insulin prices should be falling over time, yet they have more thandoubled over the last 10 years. Many diabeticsstruggle with those rising prices, sometimes withdeadly consequences. A humane health system would make in...
Source: Cato-at-liberty - August 8, 2022 Category: American Health Authors: Michael F. Cannon Source Type: blogs
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Are Pharmacological Approaches to Slow Aging in Fact Promising?
Today's open access review paper looks over a selection of what I would consider to be largely unpromising small molecules, each with evidence for their ability to slow aging, but very modestly and unreliably in most cases. Looking at the bigger picture, for much of the public it is still surprising to hear that the pace of aging can be adjusted via any form of therapy, so there is probably a role for simple, low-cost small molecule drugs in the process of education that leads to more serious efforts aimed at producing the means of human rejuvenation. Still, entirely too much effort is devoted towards small molecules that ...
Source: Fight Aging! - August 3, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Aging and the Severity of Inflammatory Infectious Disease Such as SARS-CoV-2
This article provides a pathophysiologic view of COVID-19 in older adults within the frame of inflammaging, with a focus on antiinflammatory treatments for acute and postacute disease.
How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 disease, independently from the presence of preexisting diseases. The COVID-19 mortality risk sharply increases for elderly subjects, as showed by the reports of China, Italy, and the United States. In particular, in Italy, case fatality rate for patient a...
Source: Fight Aging! - August 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
