Science Snippet: Lipids in the Limelight
This study could inform the advancement of new antibiotics.Developing new imaging technologies to track lipid droplet formation and breakdown in cancer cells. Understanding this phenomenon could shed light on why lipid droplets accumulate in these cells, which could aid in creating new therapies.
Learn about other scientific terms with the NIGMS glossary. (Source: Biomedical Beat Blog - National Institute of General Medical Sciences)
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 27, 2022 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes COVID-19 Medicines Science-snippet Source Type: blogs
Considering the Longevity of Elephants
Much of the recent research into the longevity of large mammals such as elephants has focused on Peto's paradox. If the odds of cancer are based on the number of cells in the body, all of which undergo stochastic and potentially cancerous mutations at some rate, then how is it that large mammals, with many times more cells in their body, do not exhibit a correspondingly larger risk of cancer? The answer being that for larger mammals to evolve at all, their cancer risk must be managed downward by changes in cellular biochemistry that reduce mutation rate or more efficiently destroy potentially cancerous cells. In elephants ...
Source: Fight Aging! - July 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How to Interpret and Break through Creative Blocks
By Ronald Alexander
As a mind-body therapist working with creative clients for more than 40 years, I discovered that blocks to creativity can be rooted in old losses or trauma and can occur unexpectedly.
That’s what happened to one of my clients who was a writer and who had been successful in her craft for many years. But suddenly she developed writer’s block. When she came into my office, she reported that she felt as if she were inside a large block of ice and her arms and hands were frozen. She had no ideas and would stare at her laptop screen paralyzed, unable to type more than a few sentenc...
Source: PickTheBrain | Motivation and Self Improvement - July 18, 2022 Category: Consumer Health News Authors: Ronald Alexander Tags: career confidence creativity featured motivation psychology self-improvement creative blocks mind-body therapy writers block Source Type: blogs
Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease.
Reversing Ovarian Fibrosis in Mice
https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibro...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Does Systemic Inflammation in the Body Cause Neuroinflammation in the Brain?
The chronic inflammation of aging is harmful, disruptive of tissue structure and function, altering cell behavior for the worse. The immune system reacts to many of the varied signs of molecular damage that become prevalent in old tissues, such as DNA debris from dying cells, and the result is unresolved inflammatory signaling. Neurodegenerative conditions in particular appear to be driven by inflammation, but given that the brain is separated from the body by the blood-brain barrier, and the immune systems of brain and body are also distinct and separate, how is it that inflammation in the body generates neuroinflammation...
Source: Fight Aging! - July 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
OTC Birth Control Pills –Just What The Doctor Ordered
Jeffrey A. SingerLast week, at its annual meeting, the American Medical Associationvoted to join the American College of Obstetrics and Gynecology and the American Academy of Family Physicians in calling on the Food and Drug Administration to make birth control pills available over the counter. As I have writtenhere, ACOG and AAFP have been calling for making hormonal contraception available over the counter for decades. While late to the game, the AMA ’s endorsement of OTC birth control is a welcome development.Two drug companies,HRA Pharma andCadence Health have been workingsince 2016 to develop new birth control pi...
Source: Cato-at-liberty - June 21, 2022 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Five Reasons Why Restrictive Diets Do More Harm Than Good
If you’re anything like the vast majority of the population, you started this year with one of these goals as a top priority: “get in shape”, “lose weight”, “get fit” or “get healthy”.
I get it. For the longest time my Januarys started with a rigid healthy eating plan to get back in shape and lose the holiday bulge.
Having tried almost every diet imaginable, it’s clear that most diets we follow do one of two things, they either restrict calories or restrict food groups. Even so-called it’s not a diet but a lifestyles are still a diet because you cut the amount of food, or food groups (despite th...
Source: PickTheBrain | Motivation and Self Improvement - June 14, 2022 Category: Consumer Health News Authors: drlarazib Tags: diet featured health and fitness self-improvement Source Type: blogs
Nocturnal hypertension : Something Important is being cooked in the hypertensive world !
Some physics: Why is blood under pressure?
In perfect vascular climatic conditions, the human circulatory system is comparable to a smooth flowing river irrigating 100 trillion cells, traversing many kilometers of the capillary network, to the far away tissue bed. One major difference in the river analogy is, that in human biology, the entire blood has to return back to the heart in about 30 seconds. (The fact that the venous system does this in style with near-zero pressure head is the greatest wonder in circulatory physiology)
The force per unit area, that drives the blood is the blood pressure. It is expressed...
Source: Dr.S.Venkatesan MD - June 12, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Hypertension systemic hypertension acc aha esc hypertension guidelines dippers non dippers melatonin for nocturnal hypertension night time bp reverse dipper Source Type: blogs
Perfusion Machine Restores Donor Liver for Transplant
Clinical researchers at the University of Zurich in Switzerland have created a perfusion machine to store donor livers before transplant. We originally reported on the machine back in 2020, but now the team has announced that they stored and treated a damaged liver in the machine, which would ordinarily not be suitable for transplantation. After three days of treatment the liver was healthy enough to be implanted, and was successfully placed into a patent, who is still doing well one year later. The technique could expand the potential pool of available donor livers, as it may be possible to “refurbish” less healthy li...
Source: Medgadget - June 7, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Anesthesiology Critical Care Medicine Pathology Surgery liver transplant Liver4Life transplantation UZH_en Source Type: blogs
Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology.
Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Evaluating Continuous versus Intermittent Methionine Restriction in Mice
Researchers here show that intermittent methionine restriction (four days off, three days on, alternating) produces the same metabolic benefits as continuous methionine restriction, though to a lesser degree. Methionine sensing is one of the major mechanisms by which cells respond to low calorie intake, so it is possible to trigger this response without reduced calorie intake by reducing only levels of the essential amino acid methionine in the diet. To my eyes, the most interesting outcome here is that there is a large difference in metrics between the groups placed on a zero methionine diet for three days versus those pl...
Source: Fight Aging! - June 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The ‘ Love Hormone ’ That Makes People Happier With Age (M)
Why many people become more satisfied with life as they age. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - May 30, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Happiness subscribers-only Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Removal of Lipofuscin Extends Life in Nematode Worms
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan. (Source: Fight Aging!)
Source: Fight Aging! - May 17, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Sugar and Mental Health
Sugar tastes amazing and is in so many products that most people aren’t even aware of how much they are consuming daily.
Most people are aware that sugar isn’t a healthy food, but may not realize how detrimental sugar is to your overall health.
More recent research is showing a strong link between mental health and diet, suggesting that there is a two-way street between our bellies and our brains.
What has sugar in it?
When people talk about sugar, the first thing that comes to mind is the white, granulated stuff that the Brits pour into their tea.
However, there are many forms of sugar...
Source: PickTheBrain | Motivation and Self Improvement - May 17, 2022 Category: Consumer Health News Authors: Erin Falconer Tags: diet featured happiness health and fitness psychology self-improvement sugar Source Type: blogs
