How does stress cause heart disease? Cardiology Basics
Stress and heart disease have various aspects. Stress can lead to increase in risk factors for cardiovascular disease as well as precipitate symptoms in a hitherto silent cardiovascular disease. There is also a condition known as stress cardiomyopathy or broken heart syndrome, typically precipitated by an acute stressful event like loss of spouse in an elderly female.
Most older persons have build-up of atherosclerotic plaques in the coronary arteries. When there is a sudden severe stress, heart rate and blood pressure can shoot up due to sympathetic overactivity. There is also the release of stress hormones like adrenali...
Source: Cardiophile MD - October 16, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Weekly Overseas Health IT Links – 15th October, 2022.
This article uses the one that divides providers into groups depending on the life cycle stage the clinic is at the given moment. According to this classification, medical providers fall into three groups:BeginnersGrowing clinicsWell-established providersHealth care providers are business entities, so their life cycle, like that of any business, consists of the early stage or launch, growth and maturity. At each stage, providers have different priorities and goals, and the choice of medical software solutions should be made accordingly.Medical software for beginnersThe launch phase can be tough. At this stage, the profits ...
Source: Australian Health Information Technology - October 15, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
In Health and Mortality, Do Human Genetic Variants Matter More With Age Or Less With Age?
To what degree do genetic variants drive the observed differences in human life expectancy? The old consensus guesstimate was that environment determines 75% of life expectancy, and genetic variants the other 25%. Further, it is the common wisdom that gene variants become more important to life expectancy in later life, either by providing greater resilience to specific forms of damage and dysfunction, or slowing the pace at which that damage and dysfunction accumulates. A great deal of medical research is based on the insight that gene variants are thought to provide on disease processes.
Views on genetic variants ...
Source: Fight Aging! - October 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
High Allostatic Load Correlates with Greater Risk of Cancer Mortality
Allostatic load is a compound measure of stress on the body, usually including an emphasis on inflammatory activity in the immune system. The measures making up allostatic load are raised by psychological stress, chronic exposure to pathogens or pollutants, and similar circumstances. Researchers here note that this, perhaps unsurprisingly, correlates with increased cancer mortality. Greater inflammation produces a more hospitable environment for cancer to occur and then grow, and the relationship between allostatic load and cancer may indeed be largely determined by the state of the immune system.
Allostatic load ...
Source: Fight Aging! - October 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
FOLX Health Raises $30M in Series B Funding Led by 7wireVentures; Launches Expert-Led Support Groups for LGBTQIA+ Community
The New Funding Enables the LGBTQIA+ Digital Healthcare Provider to Launch Mental and Behavioral Health Products and Further Invest in Direct-to Employer Offering
FOLX Health, the first digital healthcare service provider designed by and for the medical needs of the LGBTQIA+ community, today announced $30 million in new financing led by 7wireVentures, with participation from new investor Foresite Capital and existing investors, including Bessemer Venture Partners, Define Ventures, and Polaris Partners. Lee Shapiro, Managing Partner at 7wireVentures and former Chief Financial Officer at Livongo Health, will join FOLX Health...
Source: EMR and HIPAA - October 13, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Telemedicine and Remote Monitoring 7wireVentures behavioral health Bessemer Venture Partners Define Ventures FOLX Health Foresite Capital General Health Health IT Funding Health IT Fundings Health IT Source Type: blogs
RAS/MAPK Pathway Inhibition as an Example of the Way in Which Cancer Research Informs Aging Research
A sizable number of potential approaches to slowing aging via metabolic manipulation were first tested in the cancer research community. In part, this is because that side of the research community has tested near every compound in the libraries at some point in time, but it is also the case there are deep ties between approaches that might impact cancer and changes that might slow aging. This is particularly the case in the matter of cellular senescence, of great relevance to both cancer and aging, and the first senolytic drugs to clear senescent cells had already seen some success in the cancer field. In at least one cas...
Source: Fight Aging! - October 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
We cannot ignore nutrition ’ s impact on both pain and obesity
An excerpt from Epigenetics and the Psychology of Weight Loss: How to Lose More Weight with Less Effort. We know that people with chronic pain are more likely to be obese; but does this happen because people with chronic pain struggle to exercise and suffer from a high load of stress hormones which promote stress
Read more…
We cannot ignore nutrition’s impact on both pain and obesity originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 9, 2022 Category: General Medicine Authors: Francisco M. Torres, MD Tags: Conditions Nutrition Pain Management Source Type: blogs
TLC Todd-versations: Todd Linsky in Conversation with Dr. Alan Greene
Todd Linsky, a food and organic industry veteran, hosts the podcast Todd-versations. He interviews guests from around the globe — influencers, leaders, and innovators in their respective fields. In this episode, Todd and Dr. Greene discuss the pediatric roots of longevity, the importance of nutrition in health, Dr. Greene’s reasons for creating DrGreene.com, his next projects, and a whole host of side topics.
Transcript of Todd-versation Podcast with Todd Linsky and Dr. Greene
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this conversation is brought to you in part by Calavo Growers the family of fresh!
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hey there everybody good ...
Source: Conversations with Dr Greene - October 6, 2022 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rapamycin in Early Life Delays Development and Modestly Extends Life Span in Mice
As a general rule, 10% life extension in mice via metabolic alteration is uninteresting. It depends on the fine details, of course, but most age-slowing interventions so far discovered are in some way upregulating cellular stress response mechanisms, or adjusting growth hormone signaling. Neither of these approaches works anywhere near as well in long-lived mammals, such as our own species, as it does in short-lived mammals, such as mice, and in lower animal species. Short-lived species have life spans that are very plastic in response to environmental cues, such as the lack of nutrients that provoke greater stress respons...
Source: Fight Aging! - September 30, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Phosphodiesterase-9 inhibitors for the treatment of heart failure?
Phosphodiesterase-9 (PDE9) has the highest binding affinity among phosphodiesterases with cyclic guanosine monophosphate [1]. Cardioprotective effects of natriuretic peptides released in response to ventricular stretch in heart failure are mediated by the second messenger cyclic guanosine monophosphate (cGMP) [2]. Intracellular levels of cGMP and cAMP are governed by the activity of cyclic nucleotide phosphodiesterases. 11 phosphodiesterases with varying tissue selectivity and substrate affinity for cGMP and cAMP have been identified (PDE1 to PDE11) so far.
Increased mortality with high doses of PDE3 inhibitors milrinone,...
Source: Cardiophile MD - September 28, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021.
We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Study: Building muscle mass helps delay cognitive decline beyond the value of exercise itself
A new reason to build muscle: brain health (The Globe and Mail):
… a recent study from researchers at McGill University, published in the journal JAMA Network Open, offers a new reason for continuing to work on building muscle: It’s good for your brain, not just your biceps. Greater muscle mass, the results suggest, helps ward off cognitive decline in older adults beyond what you’d expect based on their exercise levels alone.
The findings are drawn from more than 8,000 older adults in the Canadian Longitudinal Study on Aging, with an average age of 73. They underwent a series of baseline assessments that included an ...
Source: SharpBrains - September 19, 2022 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health brain health building muscle cognitive cognitive decline cognitive-domains Cognitive-tests exercise muscle mass myokines older-adults ward off cognitive decline Source Type: blogs
β2-microglobulin in Buccal Cells as a Biomarker of Aging
In this study, we used buccal cells to examine the expression of β2M in different age groups. The expression of β2M increased significantly with fold change 3.40, 4.80, 6.60, 8.20 and 12.04 for the group of age 18-25 years, 26-35 years, 36-45 years, 46-55 years, and 56-70 years respectively. The same observation was seen with markers of biological aging (p16INK4a) with fold change 3.19, 3.90, 4.80, 8.50 and 12.40 for the group of age 18-25 years, 26-35 years, 36-45 years, 46-55 years, and 56-70 years respectively.
As expected, there was an increase in expression of inflammatory genes (IL-1β and IL-6) in the elder...
Source: Fight Aging! - September 19, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 19th 2022
Conclusion
Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life.
Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
