Fight Aging! Newsletter, October 3rd 2022

In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging. A Popular Science Article on the State of Epigenetic Clocks https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/ This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks using many different combinations of DNA methylation sites on the genome, and greater epigenetic age correlates with greater mortality and risk of age-related disease. What processes of aging actually drive epigenetic age, however? How will epigenetic age change following interventions that target only one or only several of the myriad causes and consequences of aging? Will those changes accurately reflect outcomes on mortality and disease risk? No-one knows, which is why it is currently difficult to use epigenetic clocks to assess the ability of any given approach to produce rejuvenation or a slowing of aging. Despite their obvious promise and growing popularity, epigenetic clocks still have some notable shortcomings. First, it's difficult to tell exactly how accurate biological age measurements are. Epigenetic clocks are much better at predicting...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs