Cellular Senescence in the Aging of Bone
Senescent cells accumulate with age, and disrupt tissue function via the signaling that they generate, the senescence-associated secretory phenotype (SASP). In bone tissue, the SASP contributes to breaking the balance between the activities of osteoblast cells, constantly building bone, and osteoclast cells, constantly deconstructing bone. Osteoclast activity in older people outweighs osteoblast activity, leading to a progressive loss of bone mineral density and eventual osteoporosis.
Maintaining lifelong mobility is one aim of healthy aging that allows independence and autonomy. However, falls and fragility fract...
Source: Fight Aging! - May 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing Present Biomarkers of Aging
Today's open access paper, with more than 120 contributing authors, is a tour of the broad topic of biomarkers of aging, an attempt to say at least something about every aspect of cellular biochemistry and functional capacity that is either used or proposed to be used to measure biological age, from grip strength to epigenetic clocks. Biological age is in one sense an aspirational concept, a way to measure the progression of aging that will accurately reflect mortality and disease risk. In another sense, biological age is self-evidently real. Different people age at different rates, and exhibit very different risk levels f...
Source: Fight Aging! - May 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How Your Brain Is Connected to Your Gut: 7 Facts About Gut Health
We've all had a "gut feeling," or someone has told us to "follow our gut." It's that feeling that we may know something just by knowing—our intuition telling us something. It turns out that this feeling is more than just a feeling. The human body is an intricate series of systems, each individually playing a vital role in our overall health and well-being, and at the same time, they are all connected to make our whole body work.
One of these systems is the gut, also known as the gastrointestinal tract, which is responsible for digesting food and absorbing nutrients. When we combine its superpowers with the brain...
Source: PickTheBrain | Motivation and Self Improvement - April 28, 2023 Category: Consumer Health News Authors: Irene Rondom Tags: health and fitness self-improvement brain health gut health Source Type: blogs
Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved.
Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Overview of Early Work on the mTOR Inhibitor Rapamycin
The path to understanding that pharmacological inhibition of mTOR replicates some of the calorie restriction response to cause a slowing of aging started with studies of rapamycin. The primary mechanism of interest is upregulation of autophagy, a cellular housekeeping mechanism that is involved in a range of interventions that slow aging in short-lived species. Other mechanisms may well turn out to be involved, as altering metabolism is a complex business and still incompletely understood.
The various mTOR inhibitors are collectively one of the most studied, and arguably best of the existing approaches to alter meta...
Source: Fight Aging! - April 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context.
Glycine Supplementation as a Methionine Restriction Mimetic
https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/
Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Odor Influences Female Mouse Development and Life Span
Olfactory clues can be added to the many items that influence the highly plastic life span of short-lived species. You might recall that flies respond to the scent of food in ways that accelerate aging, while here researchers show that female odors slow development and extend life in female mice by 8% to 9%, give or take. This mechanism is one of many reasons as why one should be skeptical of any life span study in mice that shows effect sizes of much less than 20%, and was conducted in anything less than a very rigorous, controlled manner, with a large number of mice. The life span of short lived species is just very sens...
Source: Fight Aging! - April 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Tradeoff of Working with Short-Lived Laboratory Species
It is cheaper and faster to study aging - and potential approaches to treat aging - in short-lived species. The disadvantage is that much of what is learned and achieved will be irrelevant to aging as it occurs in longer-lived species such as our own. The response to calorie restriction, an upregulation of cellular housekeeping mechanisms that lengthens life, fortunately evolved early on in the development of life, and the biochemistry is surprisingly consistent even across widely divergent species. Thus much can be learned of it in lower animals with short life spans. Unfortunately, it turns out that this class of interve...
Source: Fight Aging! - March 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Benefits of Intermittent Fasting
The paper noted here discusses a range of studies assessing the ability of forms of intermittent fasting to improve long-term health and life expectancy. Results are generally positive, but one should expect long-lived mammals to exhibit smaller gains in longevity than are observed in short-lived mammals, following the known outcomes of calorie restriction. Intermittent fasting is not as well studied as the practice of calorie restriction, but does appear to work via a similar set of mechanisms, even when overall calorie intake is not much reduced. Time spent in a state of hunger, and the metabolic changes provoked by hung...
Source: Fight Aging! - March 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Levels Is Making Metabolism and Blood Glucose Tracking Accessible To Everyone
Levels has done something truly transformative: the company made continuous glucose monitors (CGMs) accessible to the general population and every day consumer.
In many circles, it seems the trend of bringing healthcare to the home and directly to the patient is continuing, but understanding metabolism and lifestyle habits through this new tech trend of smart, wearable devices adds another important component to enjoying improved health and well-being.
If you imagine your body as a well-oiled machine that needs to be maintained, the sources of fuel and nutrition that you provide it are paramount for its efficiency an...
Source: Medgadget - March 23, 2023 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Medicine Sports Medicine CGM glucose Levels Source Type: blogs
The orgasmic heart beat
TL:DR – Sex can double or treble a person’s heart rate, but this is a normal physiological response provided the rate goes back to normal within a few minutes.
Love might make your heart skip a beat, but love-making definitely gets it pumping. Indeed, sexual activity will inevitably raise your bpm, beats per minute, especially as a person approaches orgasm. A friend with a fake FitBit was curious about the trajectory of heart rate during sex and wore his monitor (around his wrist) in the bedroom one night. As he and his missus slid between the sheets, he set it to “other” workout and then synced th...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 17, 2023 Category: Science Authors: David Bradley Tags: Health and Medicine Sex Source Type: blogs
Breaking the cycle of childhood obesity
Every specialty has its burden, and pediatric endocrinology’s is obesity. Primary care providers refer because they or the child’s parents suspect the cause is hormonal. It almost never is. The overly adipose child invariably has, using older terminology, exogenous obesity. Traditionally, this has implied excessive calorie intake and inadequate expenditure (the “overactive fork and underactive
Read more…
Breaking the cycle of childhood obesity originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 14, 2023 Category: General Medicine Authors: Martin C. Young, MD Tags: Conditions Obesity Pediatrics Source Type: blogs
Fool women twice? Drug makers revive menopause as a “ disease. ”
In the words of the late soccer great Pelé spoofed on Saturday Night Live, women’s health has been “very, very good” for drug makers. In 2002, 61 million prescriptions were written for women in the U.S. for hormones to treat the so-called “disease” of menopause (which was once treated with electroshock therapy—yes, ECT). Until the
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Fool women twice? Drug makers revive menopause as a “disease.” originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 8, 2023 Category: General Medicine Authors: Martha Rosenberg Tags: Conditions OB/GYN Source Type: blogs
Semaglutide – the “ skinny jab ”
TL:DR – Semaglutide is known to US celebrities as the “skinny jab” and has apparently been the subject of a weight-loss craze. It has now been approved in the UK for weight-loss in the clinically obese.
Semaglutide is a pharmaceutical that can help control the symptoms of Type 2 diabetes for which it was first used. The nickname, the “skinny jab” comes from the drug’s activity as an appetite suppressant used in helping overweight people and the obese reduce their body weight. It is sold under the brand names Ozempic, Wegovy and Rybelsus and was originally developed by Novo Nordisk in 20...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 8, 2023 Category: Science Authors: David Bradley Tags: Health and Medicine Obesity Source Type: blogs
