Penicillin Allergy Testing and Delabeling for Patients Who Are Prescribed Penicillin: A Systematic Review for a World Health Organization Guideline
AbstractSecondary prevention with penicillin aims to prevent further episodes of acute rheumatic fever and subsequent development of rheumatic heart disease (RHD). Penicillin allergy, self-reported by 10% of the population, can affect secondary prevention programs. We aimed to assess the role for (i) routine penicillin allergy testing and the (ii) safety of penicillin allergy delabeling approaches in this context. We searched MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, WHO ICTRP, ISRCTN, and CPCI-S to identify the relevant reports. We found 2419 records, but no studies addressed our initial question. Following advice fro...
Source: Clinical Reviews in Allergy and Immunology - May 2, 2024 Category: Allergy & Immunology Source Type: research
2024 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society. The Special Report discusses the larger health care system for older adults with cognitive issues, focusing on the role of caregivers and non-physician health care professionals. An estimated 6.9 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060, barring the development of medical breakthroughs to prevent ...
Source: The Journal of Alzheimers Association - May 1, 2024 Category: Psychiatry Source Type: research
A lipid activated color switchable probe for the imaging of diseased aortic valves
Talanta. 2024 Apr 20;275:126069. doi: 10.1016/j.talanta.2024.126069. Online ahead of print.ABSTRACTLipid deposition has been considered one of the key factors in the occurrence of valvular heart disease (VHD) and a great potential target for the diagnosis of VHD. However, the development of lipid imaging technologies and efficient lipid specific probes is in urgent demand. In this work, we have prepared a lipid droplets (LDs) targeted fluorescence probe CPTM based on a push-pull electronic structure for the imaging of diseased aortic valves. CPTM showed obvious twisted intramolecular charge transfer (TICT) effect and its e...
Source: Talanta - May 1, 2024 Category: Chemistry Authors: Weihua Zhuang Junli Li Tianyi Qu Ruochen Shao Jingruo Chen Shufen Li Mao Chen Yunbing Wang Source Type: research
2024 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society. The Special Report discusses the larger health care system for older adults with cognitive issues, focusing on the role of caregivers and non-physician health care professionals. An estimated 6.9 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060, barring the development of medical breakthroughs to prevent ...
Source: The Journal of Alzheimers Association - May 1, 2024 Category: Psychiatry Source Type: research
The Association Between Religious Belief and Postoperative Psychological Status and Quality of Life of Parents of Children with Congenital Heart Disease: A Single Center Experience in Southeast China
This study aimed to investigate the association of religious belief on the postoperative psychological status and quality of life of parents of children with congenital heart disease (CHD). This was a cross-sectional study conducted at a provincial children ’s hospital in Fujian Province, China. Parents of postoperative children with CHD in the early postoperative period were included in this study between January 2020 and September 2020. The parents were divided into a religious belief group (n = 39) and a nonreligious belief group (n = 42) depending on whether they had religious beliefs. The Religious Coping Qu...
Source: Journal of Religion and Health - May 1, 2024 Category: Medical Ethics Source Type: research
Rheumatic heart disease of the mitral valve alongside the papillary fibroelastoma of the aortic valve: A case report
We present the case of a 47-year-old woman who was admitted to the hospital due to worsening dyspnea and fatigue, during which time she discovered an aortic valve papillary fibroelastoma. Further investigations revealed two thrombi in her left atrium and left atrial appendage, along with significant rheumatic mitral valve stenosis. The patient underwent thrombectomy, mitral valve replacement, and valve-sparing aortic valve tumor resection. Following surgery, the patient's recovery was unremarkable. This case report emphasizes the need for a comprehensive evaluation in patients with rheumatic mitral stenosis, considering al...
Source: Clinical Case Reports - May 1, 2024 Category: General Medicine Authors: Naser Khezerlouy Aghdam,
Mitra Delkhah,
Saeid Danayi,
Navid Sobhi Tags: CASE REPORT Source Type: research
Cost analysis for initiating an integrated package of essential non-communicable disease interventions (PEN-Plus) in Kondoa District Hospital, Tanzania: a time-driven activity-based costing (TDABC) study protocol
This study aims to estimate the cost of initiating PEN-Plus for rheumatic heart disease, sickle cell disease and type 1 diabetes at Kondoa district hospital in Tanzania.
Methods and analysis
We will employ time-driven activity-based costing (TDABC) to quantify the capacity cost rates (CCR), and capital and recurrent costs associated with the implementation of PEN-Plus. Data on resource consumption will be collected through direct observations and interviews with nurses, the medical officer in charge and the heads of laboratory and pharmacy units/departments. Data on contact times for targeted NCDs will be collected by obs...
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Ndumwa, H. P., Mori, A. T., Ruhago, G. M., Willilo, R., McBain, R., Boudreaux, C., Wroe, E., Adler, A. J., Bukhman, G., Mayige, M. T., Kaarboe, O. Tags: Open access, Health economics Source Type: research
Therapeutic benefit of laughter yoga and deep breathing exercises with oral doses of Withania somnifera root extracts in Parkinson's disease patients.
Background: Laughter has been shown to generally improve mood in physically healthy adults, and specifically in adults with heart disease or cancer, but little research exists regarding the impact of laughter in adults with Parkinson ’s disease (PD). To study new methods of controlling Parkinson’s disease complications by laughter yoga and deep breathing exercise with Withania somnifera root extract (WSE) dose in PD patients in rural Delhi metro population. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Kumar, V. Sharma Source Type: research
Outcomes After Transcatheter Mitral Valve Intervention: Threatened by Tricuspid Regurgitation
The tricuspid valve (TV) was historically referred to as the forgotten valve and considered to be a passive structure, on the systemic venous side of the heart, without clinically significant function. However, recent studies showed all-cause mortality was higher for tricuspid regurgitation (TR) than for aortic-valve disease or mitral-valve disease (hazard ratios: 2.74, 1.62, 1.25 respectively).1 TR is classified into primary, secondary or implantable device related. Primary tricuspid regurgitation occurs because of intrinsic valve disease and is attributable to congenital anomalies, infective endocarditis, rheumatic disea...
Source: The American Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Srinivasa Potluri Tags: Editorial Source Type: research
Navigating complex waters: Revascularization strategies and outcomes in post-CABG patients
Cardiovascular disease (CVD), in particular ischemic heart disease (IHD), remains a leading cause of mortality worldwide [1]. Patients with advanced coronary artery disease often require coronary artery bypass grafting (CABG) to restore sufficient blood flow to the myocardium. Managing patients post-CABG presents substantial challenges due to complex comorbidities that can impede cardiac rehabilitation and hasten atherosclerosis, often necessitating repeat revascularization. Although CABG is a long-established effective revascularization strategy, the durability of bypass grafts is threatened by the progression of native c...
Source: International Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Mohammed Alghammass, Shilpkumar Arora Source Type: research
Dronedarone for the Treatment of Atrial Arrhythmias in Adults With Congenital Heart Disease
CONCLUSION: Dronedarone can be effective for adult patients with congenital heart disease and atrial arrhythmias for whom more established therapies have failed, and with close monitoring it can be safely tolerated.PMID:38686681 | DOI:10.14503/THIJ-22-7993 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Mahdi S Agha Peter R Ermis Wayne J Franklin Dhaval R Parekh Angeline D Opina Jeffrey J Kim Christina Y Miyake Santiago O Valdes Wilson W Lam Source Type: research
Study on the Influence of Management Style Based on the HOPE Model on GRACE Score, LVEF, and Quality of Life of Patients with Myocardial Infarction
CONCLUSIONS: The HOPE management model can effectively improve the cardiac function and quality of life of patients with myocardial infarction, and reduce GRACE scores and the incidence of in-hospital cardiovascular adverse events, which can as a comprehensive approach to improve clinical outcomes and enhance the quality of life for patients with myocardial infarction.PMID:38687863 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Yan Li Yu Wang Source Type: research
TriKSV-LG: a robust approach to disease prediction in healthcare systems using AI and Levy Gazelle optimization
Comput Methods Biomech Biomed Engin. 2024 Apr 30:1-17. doi: 10.1080/10255842.2024.2339479. Online ahead of print.ABSTRACTA seamless connection between the Internet and people is provided by the Internet of Things (IoT). Furthermore, lives are enhanced using the integration of the cloud layer. In the healthcare domain, a reactive healthcare strategy is turned into a proactive one using predictive analysis. The challenges faced by existing techniques are inaccurate prediction and a time-consuming process. This paper introduces an Artificial Intelligence (AI) and IoT-based disease prediction method, the TriKernel Support Vect...
Source: Computer Methods in Biomechanics and Biomedical Engineering - April 30, 2024 Category: Biomedical Engineering Authors: Kavitha Dhanushkodi Prema Vinayagasundaram Vidhya Anbalagan Surendran Subbaraj Ravikumar Sethuraman Source Type: research
Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
A Structure-Based Pharmacophore Modelling Approach to Identify and Design New Neprilysin (NEP) Inhibitors: An in silico-based investigation
Arch Biochem Biophys. 2024 Apr 28:110019. doi: 10.1016/j.abb.2024.110019. Online ahead of print.ABSTRACTNeutral endopeptidase or neprilysin (NEP) cleaves the natriuretic peptides, bradykinin, endothelin, angiotensin II, amyloid β protein, substance P, etc., thus modulating their effects on heart, kidney, and other organs. NEP has a proven role in hypertension, heart disease, renal disease, Alzheimer's, diabetes, and some cancers. NEP inhibitor development has been in focus since the US FDA approved a combination therapy of angiotensin II type 1 receptor inhibitor (valsartan) and NEP inhibitor (sacubitril) for use in heart...
Source: Archives of Biochemistry and Biophysics - April 30, 2024 Category: Biochemistry Authors: Shikha Thakur Apurba Sinhari Anil Bhanudas Gaikwad Hemant R Jadhav Source Type: research
