Early and Long-Term Results of Simultaneous and Staged Revascularization of Coronary and Carotid Arteries
CONCLUSIONS: This study revealed no significant difference in the impact of simultaneous CABG + CEA or staged CABG/CEA on the incidence of death, stroke, MI, and MACEs over a 30-day and long-term follow-up period. Although the immediate results indicated an increased risk of a complicated course (attributable to overall complications) and more prolonged ventilation after simultaneous CABG + CEA compared with staged CABG/CEA, this did not lead to an increase in fatal complications. Therefore, the implementation of either tactic is considered eligible and appropriate following a thorough operative risk assessment.PMID:386514...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Elena Golukhova Igor Sigaev Milena Keren Inessa Slivneva Bektur Berdibekov Nina Sheikina Olga Kozlova Valery Arakelyan Irina Volkovskaya Tatiana Zavalikhina Susanna Avakova Source Type: research
Clinical Value of the Diagonal Earlobe Crease in Patients with Chest Pain for Diagnosing Coronary Heart Disease
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 23, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Very short sleep duration reveals a proteomic fingerprint that is selectively associated with incident diabetes mellitus but not with incident coronary heart disease: a cohort study
The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns as... (Source: BMC Medicine)
Source: BMC Medicine - April 23, 2024 Category: Internal Medicine Authors: Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Gunnar Engstr öm, Jan Nilsson, Marju Orho-Melander, Peter M. Nilsson and Olle Melander Tags: Research article Source Type: research
Fetal transposition of the great arteries: 3D virtual and physical models from ultrasound datasets
AbstractTransposition of the great arteries (TGA) is a cyanotic congenital heart disease characterized by ventriculoarterial discordance and atrioventricular concordance with the great arteries in a parallel relationship. Prenatal diagnosis of TGA has implications for postnatal outcomes, allowing for planned delivery and perinatal management. Three-dimensional virtual or physical models of fetal TGA allow better understanding of fetal cardiac anomalies by parents and interactive discussion among the multidisciplinary team (obstetricians, pediatricians, maternal-fetal specialists, pediatric cardiologists, and cardiovascular...
Source: The International Journal of Cardiovascular Imaging - April 23, 2024 Category: Radiology Source Type: research
Intracoronary physiology: Easier to measure, but still complex. The art of interpreting intracoronary pressure wire data.
Since the introduction of fractional flow reserve (FFR) [1], coronary physiology has progressively gained prominence in coronary diagnosis and intervention. Its implementation has led to improved outcomes, safely avoiding unnecessary revascularisations without increasing or even decreasing the number of adverse events. Recently, FFR has facilitated a new approach to understanding ischemic heart disease, explaining its symptoms and consequences beyond coronary stenoses [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 23, 2024 Category: Cardiology Authors: Ram ón López-Palop, Pilar Carrillo, Alfonso Freites Source Type: research
From phenotype to mechanism: Prenatal spectrum of NKAP mutation-related disorder and its pathogenesis inducing congenital heart disease
J Cell Mol Med. 2024 Apr;28(8):e18305. doi: 10.1111/jcmm.18305.ABSTRACTNKAP mutations are associated with Hackmann-Di Donato-type X-linked syndromic intellectual developmental disorder (MRXSHD, MIM: #301039). Here, we elucidate the potential prenatal manifestation of NKAP mutation-associated disorder for the first time, alongside revealing the relationship between NKAP mutations and congenital heart defect (CHD) in the Chinese population. An NKAP mutation (NM_024528.4: c.988C>T, p.Arg330Cys) was identified in two foetuses presenting with CHD. Subsequent mechanistic exploration revealed a marked downregulation of NKAP tr...
Source: J Cell Mol Med - April 22, 2024 Category: Molecular Biology Authors: Xiayuan Xu Chengcheng Gao Fenglei Ye Aohui Peng Jianbo Xu Keqin Jin Jun Zhang Yun Ye Yanfen Yang Xuan Zhang Shuangshuang Shen Fan Jin Source Type: research
From phenotype to mechanism: Prenatal spectrum of NKAP mutation-related disorder and its pathogenesis inducing congenital heart disease
J Cell Mol Med. 2024 Apr;28(8):e18305. doi: 10.1111/jcmm.18305.ABSTRACTNKAP mutations are associated with Hackmann-Di Donato-type X-linked syndromic intellectual developmental disorder (MRXSHD, MIM: #301039). Here, we elucidate the potential prenatal manifestation of NKAP mutation-associated disorder for the first time, alongside revealing the relationship between NKAP mutations and congenital heart defect (CHD) in the Chinese population. An NKAP mutation (NM_024528.4: c.988C>T, p.Arg330Cys) was identified in two foetuses presenting with CHD. Subsequent mechanistic exploration revealed a marked downregulation of NKAP tr...
Source: Molecular Medicine - April 22, 2024 Category: Molecular Biology Authors: Xiayuan Xu Chengcheng Gao Fenglei Ye Aohui Peng Jianbo Xu Keqin Jin Jun Zhang Yun Ye Yanfen Yang Xuan Zhang Shuangshuang Shen Fan Jin Source Type: research
The combination of deep learning and pseudo-MS image improves the applicability of metabolomics to congenital heart defect prenatal screening
In conclusion, the CNN model based on pseudo-MS images holds promise for real-world and clinical applications due to its better repeatability.PMID:38648686 | DOI:10.1016/j.talanta.2024.126109 (Source: Talanta)
Source: Talanta - April 22, 2024 Category: Chemistry Authors: Borui Sun Yiwei Fang Hui Yang Fan Meng Chao He Yun Zhao Kai Zhao Huiping Zhang Source Type: research
Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among U.S. Residents
CONCLUSIONS: Our findings identified critical pollutants for targeted emission controls and suggested that abnormal temperature changes chronically affected cardiovascular health by interacting with air pollution, not directly.PMID:38648692 | DOI:10.1016/j.envint.2024.108651 (Source: Environment International)
Source: Environment International - April 22, 2024 Category: Environmental Health Authors: Yaguang Wei Heresh Amini Xinye Qiu Edgar Castro Tingfan Jin Kanhua Yin Bryan N Vu James Healy Yijing Feng Jiangshan Zhang Brent Coull Joel Schwartz Source Type: research
The association of pre-cancer diagnosis cardiovascular risk factors with memory aging after a cancer diagnosis, overall and by race/ethnicity
ConclusionsCVRFs were associated with worse baseline memory function, but not decline, for cancer-free adults and cancer survivors. Racial disparities were largely similar between cancer survivors and cancer-free adults.Implications for Cancer SurvivorsThese findings may inform hypotheses about pre-diagnosis multimorbidity and cognitive aging of cancer survivors from diverse groups. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - April 22, 2024 Category: Cancer & Oncology Source Type: research
Genes, Vol. 15, Pages 518: 22q11.2 Deletion Syndrome: Influence of Parental Origin on Clinical Heterogeneity
This study aimed to explore the association between clinical heterogeneity in 22q11.2DS and the parental origin of the deletion. The parental origin of the deletion was determined for 61 individuals with 22q11.2DS by genotyping DNA microsatellite markers and single-nucleotide polymorphisms (SNPs). Among the 61 individuals, 29 (47.5%) had a maternal origin of the deletion, and 32 (52.5%) a paternal origin. Comparison of the frequency of the main clinical features between individuals with deletions of maternal or paternal origin showed no statistically significant difference. However, Truncus arteriosus, pulmonary atresia, s...
Source: Genes - April 21, 2024 Category: Genetics & Stem Cells Authors: Melissa Bittencourt de Wallau Ana Carolina Xavier Carolina Ara újo Moreno Chong Ae Kim Elaine Lustosa Mendes Erlane Marques Ribeiro Amanda Oliveira T êmis Maria Félix Agnes Cristina Fett-Conte Luciana Cardoso Bonadia Gabriela Rold ão Correia-Costa Isa Tags: Article Source Type: research
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print.ABSTRACTBACKGROUND: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate m...
Source: Australian Family Physician - April 20, 2024 Category: Primary Care Authors: GBD 2021 Diseases and Injuries Collaborators Source Type: research
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print.ABSTRACTBACKGROUND: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate m...
Source: Australian Family Physician - April 20, 2024 Category: Primary Care Authors: GBD 2021 Diseases and Injuries Collaborators Source Type: research
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print.ABSTRACTBACKGROUND: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate m...
Source: Australian Family Physician - April 20, 2024 Category: Primary Care Authors: GBD 2021 Diseases and Injuries Collaborators Source Type: research
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print.ABSTRACTBACKGROUND: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate m...
Source: Australian Family Physician - April 20, 2024 Category: Primary Care Authors: GBD 2021 Diseases and Injuries Collaborators Source Type: research
