Preventable Premature Deaths from the Five Leading Causes of Death in Nonmetropolitan and Metropolitan Counties, United States, 2010-2022
This report provides estimates of preventable premature deaths for additional years (2010-2022).PERIOD COVERED: 2010-2022.DESCRIPTION OF SYSTEM: Mortality data for U.S. residents from the National Vital Statistics System were used to calculate preventable premature deaths from the five leading causes of death among persons aged <80 years. CDC's National Center for Health Statistics urban-rural classification scheme for counties was used to categorize the deaths according to the urban-rural county classification level of the decedent's county of residence (1: large central metropolitan [most urban], 2: large fringe metro...
Source: MMWR Surveill Summ - April 30, 2024 Category: Epidemiology Authors: Macarena C Garc ía Lauren M Rossen Kevin Matthews Gery Guy Katrina F Trivers Cheryll C Thomas Linda Schieb Michael F Iademarco Source Type: research

Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research

Dronedarone for the Treatment of Atrial Arrhythmias in Adults With Congenital Heart Disease
CONCLUSION: Dronedarone can be effective for adult patients with congenital heart disease and atrial arrhythmias for whom more established therapies have failed, and with close monitoring it can be safely tolerated.PMID:38686681 | DOI:10.14503/THIJ-22-7993 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Mahdi S Agha Peter R Ermis Wayne J Franklin Dhaval R Parekh Angeline D Opina Jeffrey J Kim Christina Y Miyake Santiago O Valdes Wilson W Lam Source Type: research

Study on the Influence of Management Style Based on the HOPE Model on GRACE Score, LVEF, and Quality of Life of Patients with Myocardial Infarction
CONCLUSIONS: The HOPE management model can effectively improve the cardiac function and quality of life of patients with myocardial infarction, and reduce GRACE scores and the incidence of in-hospital cardiovascular adverse events, which can as a comprehensive approach to improve clinical outcomes and enhance the quality of life for patients with myocardial infarction.PMID:38687863 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Yan Li Yu Wang Source Type: research

Sex differences in delay times in ST-segment elevation myocardial infarction: A cohort study
CONCLUSIONS: Women took longer to go to health care services and had a longer delay both in the diagnosis of STEMI and in coronary reperfusion. It is imperative to emphasize the necessity of educating women about the recognition of ischemic heart disease symptoms, empowering them to raise early alarms and seek timely medical attention.PMID:38688735 | DOI:10.1016/j.medcli.2024.02.015 (Source: Medicina Clinica)
Source: Medicina Clinica - April 30, 2024 Category: General Medicine Authors: Pablo Juan-Salvadores Mar ía Castro-Rodríguez V íctor Alfonso Jiménez-Díaz Cesar Veiga Laura Busto Saleta Fern ández-Barbeira Andr és Iñiguez-Romo Source Type: research

TriKSV-LG: a robust approach to disease prediction in healthcare systems using AI and Levy Gazelle optimization
Comput Methods Biomech Biomed Engin. 2024 Apr 30:1-17. doi: 10.1080/10255842.2024.2339479. Online ahead of print.ABSTRACTA seamless connection between the Internet and people is provided by the Internet of Things (IoT). Furthermore, lives are enhanced using the integration of the cloud layer. In the healthcare domain, a reactive healthcare strategy is turned into a proactive one using predictive analysis. The challenges faced by existing techniques are inaccurate prediction and a time-consuming process. This paper introduces an Artificial Intelligence (AI) and IoT-based disease prediction method, the TriKernel Support Vect...
Source: Computer Methods in Biomechanics and Biomedical Engineering - April 30, 2024 Category: Biomedical Engineering Authors: Kavitha Dhanushkodi Prema Vinayagasundaram Vidhya Anbalagan Surendran Subbaraj Ravikumar Sethuraman Source Type: research

Preventable Premature Deaths from the Five Leading Causes of Death in Nonmetropolitan and Metropolitan Counties, United States, 2010-2022
This report provides estimates of preventable premature deaths for additional years (2010-2022).PERIOD COVERED: 2010-2022.DESCRIPTION OF SYSTEM: Mortality data for U.S. residents from the National Vital Statistics System were used to calculate preventable premature deaths from the five leading causes of death among persons aged <80 years. CDC's National Center for Health Statistics urban-rural classification scheme for counties was used to categorize the deaths according to the urban-rural county classification level of the decedent's county of residence (1: large central metropolitan [most urban], 2: large fringe metro...
Source: MMWR Surveill Summ - April 30, 2024 Category: Epidemiology Authors: Macarena C Garc ía Lauren M Rossen Kevin Matthews Gery Guy Katrina F Trivers Cheryll C Thomas Linda Schieb Michael F Iademarco Source Type: research

A Structure-Based Pharmacophore Modelling Approach to Identify and Design New Neprilysin (NEP) Inhibitors: An in silico-based investigation
Arch Biochem Biophys. 2024 Apr 28:110019. doi: 10.1016/j.abb.2024.110019. Online ahead of print.ABSTRACTNeutral endopeptidase or neprilysin (NEP) cleaves the natriuretic peptides, bradykinin, endothelin, angiotensin II, amyloid β protein, substance P, etc., thus modulating their effects on heart, kidney, and other organs. NEP has a proven role in hypertension, heart disease, renal disease, Alzheimer's, diabetes, and some cancers. NEP inhibitor development has been in focus since the US FDA approved a combination therapy of angiotensin II type 1 receptor inhibitor (valsartan) and NEP inhibitor (sacubitril) for use in heart...
Source: Archives of Biochemistry and Biophysics - April 30, 2024 Category: Biochemistry Authors: Shikha Thakur Apurba Sinhari Anil Bhanudas Gaikwad Hemant R Jadhav Source Type: research

Managing Hepatotoxicity Caused by Anti-tuberculosis Drugs: A Comparative Study of Approaches
CONCLUSION: Drug-induced hepatotoxicity is a common occurrence that often results in treatment discontinuation. Understanding the prevalence of this complication and identifying appropriate methods of rechallenge treatment is crucial to reducing complications and mortality rates.PMID:38685836 | DOI:10.34172/aim.2024.19 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Faeze Abbaspour Malihe Hasannezhad Hossein Khalili SeyedAhmad SeyedAlinaghi Sirous Jafari Source Type: research

Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research

Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research

Dronedarone for the Treatment of Atrial Arrhythmias in Adults With Congenital Heart Disease
CONCLUSION: Dronedarone can be effective for adult patients with congenital heart disease and atrial arrhythmias for whom more established therapies have failed, and with close monitoring it can be safely tolerated.PMID:38686681 | DOI:10.14503/THIJ-22-7993 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Mahdi S Agha Peter R Ermis Wayne J Franklin Dhaval R Parekh Angeline D Opina Jeffrey J Kim Christina Y Miyake Santiago O Valdes Wilson W Lam Source Type: research

Study on the Influence of Management Style Based on the HOPE Model on GRACE Score, LVEF, and Quality of Life of Patients with Myocardial Infarction
CONCLUSIONS: The HOPE management model can effectively improve the cardiac function and quality of life of patients with myocardial infarction, and reduce GRACE scores and the incidence of in-hospital cardiovascular adverse events, which can as a comprehensive approach to improve clinical outcomes and enhance the quality of life for patients with myocardial infarction.PMID:38687863 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Yan Li Yu Wang Source Type: research

Sex differences in delay times in ST-segment elevation myocardial infarction: A cohort study
CONCLUSIONS: Women took longer to go to health care services and had a longer delay both in the diagnosis of STEMI and in coronary reperfusion. It is imperative to emphasize the necessity of educating women about the recognition of ischemic heart disease symptoms, empowering them to raise early alarms and seek timely medical attention.PMID:38688735 | DOI:10.1016/j.medcli.2024.02.015 (Source: Medicina Clinica)
Source: Medicina Clinica - April 30, 2024 Category: General Medicine Authors: Pablo Juan-Salvadores Mar ía Castro-Rodríguez V íctor Alfonso Jiménez-Díaz Cesar Veiga Laura Busto Saleta Fern ández-Barbeira Andr és Iñiguez-Romo Source Type: research

Managing Hepatotoxicity Caused by Anti-tuberculosis Drugs: A Comparative Study of Approaches
CONCLUSION: Drug-induced hepatotoxicity is a common occurrence that often results in treatment discontinuation. Understanding the prevalence of this complication and identifying appropriate methods of rechallenge treatment is crucial to reducing complications and mortality rates.PMID:38685836 | DOI:10.34172/aim.2024.19 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Faeze Abbaspour Malihe Hasannezhad Hossein Khalili SeyedAhmad SeyedAlinaghi Sirous Jafari Source Type: research