E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population
This study was conducted on 200 participants who were admitted to the surgical specialty hospital-cardiac center in Erbil City, Iraq between October 2021 and May 2022. Based on the outcomes of the clinical examination, laboratory tests, coronary angiography (COA), acute myocardial infarction (MI) type ST-elevation myocardial infarction (STEMI), stable angina pectoris (SAP), and healthy control groups were tested. Each sample was subjected to Sanger sequencing. The polymorphism was significantly linked to stable angina and myocardial infarction Genotype CC was higher in SAP when compared with MI and control groups which was...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Lajan Qasim Rahman Ruqaya Muhammad Ghareeb Source Type: research
ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):125-129. doi: 10.14715/cmb/2024.70.3.18.ABSTRACTMyocardial ischemia/reperfusion injury (MIRI) is an irreversible adverse event during the management of coronary heart disease that lacks effective controls. The underlying mechanism of MIRI still requires further investigation. Recent studies have suggested that overexpression of ATF3 protects against MIRI by regulating inflammatory responses, ferroptosis, and autophagy. The downstream target of ATF3, EGR1, also showed cardioprotective properties against MIRI by promoting autophagy. Therefore, further investigating the effect...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Li Li Gang Fu Caiyun Liu Yanling Liu Source Type: research
Differential age-specific associations of LDL cholesterol and body mass index with coronary heart disease
CONCLUSIONS: There were differential age-specific associations of LDLc and BMI with the risk of developing CHD, calling for future efforts to discriminate the age-different benefits from lipids management or weight control on the primary prevention for CHD.PMID:38652975 | DOI:10.1016/j.atherosclerosis.2024.117542 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Jun Xiao Hongye Wei Ziting Gao Liangwan Chen Weimin Ye Wuqing Huang Source Type: research
Early and Long-Term Results of Simultaneous and Staged Revascularization of Coronary and Carotid Arteries
CONCLUSIONS: This study revealed no significant difference in the impact of simultaneous CABG + CEA or staged CABG/CEA on the incidence of death, stroke, MI, and MACEs over a 30-day and long-term follow-up period. Although the immediate results indicated an increased risk of a complicated course (attributable to overall complications) and more prolonged ventilation after simultaneous CABG + CEA compared with staged CABG/CEA, this did not lead to an increase in fatal complications. Therefore, the implementation of either tactic is considered eligible and appropriate following a thorough operative risk assessment.PMID:386514...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Elena Golukhova Igor Sigaev Milena Keren Inessa Slivneva Bektur Berdibekov Nina Sheikina Olga Kozlova Valery Arakelyan Irina Volkovskaya Tatiana Zavalikhina Susanna Avakova Source Type: research
ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):125-129. doi: 10.14715/cmb/2024.70.3.18.ABSTRACTMyocardial ischemia/reperfusion injury (MIRI) is an irreversible adverse event during the management of coronary heart disease that lacks effective controls. The underlying mechanism of MIRI still requires further investigation. Recent studies have suggested that overexpression of ATF3 protects against MIRI by regulating inflammatory responses, ferroptosis, and autophagy. The downstream target of ATF3, EGR1, also showed cardioprotective properties against MIRI by promoting autophagy. Therefore, further investigating the effect...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Li Li Gang Fu Caiyun Liu Yanling Liu Source Type: research
E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population
This study was conducted on 200 participants who were admitted to the surgical specialty hospital-cardiac center in Erbil City, Iraq between October 2021 and May 2022. Based on the outcomes of the clinical examination, laboratory tests, coronary angiography (COA), acute myocardial infarction (MI) type ST-elevation myocardial infarction (STEMI), stable angina pectoris (SAP), and healthy control groups were tested. Each sample was subjected to Sanger sequencing. The polymorphism was significantly linked to stable angina and myocardial infarction Genotype CC was higher in SAP when compared with MI and control groups which was...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Lajan Qasim Rahman Ruqaya Muhammad Ghareeb Source Type: research
RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention
Mol Aspects Med. 2024 Apr 22;97:101274. doi: 10.1016/j.mam.2024.101274. Online ahead of print.ABSTRACTPhysical exercise has been widely acknowledged as a beneficial lifestyle alteration and a potent non-pharmacological treatment for heart disease. Extensive investigations have revealed the beneficial effects of exercise on the heart and the underlying mechanisms involved. Exercise is considered one of the key factors that can lead to epigenetic alterations. The increasing number of identified molecules in the exercised heart has led to many studies in recent years that have explored the cellular function of ncRNAs and RNA ...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Lijun Wang Wensi Wan Shuang Zhang Tarun Keswani Guoping Li Junjie Xiao Source Type: research
Interrupting Effect of Social Distancing on Ischemic Heart Disease, Asthma, Stroke, and Suicide Attempt Patients by PM < sub > 2.5 < /sub > Exposure
CONCLUSION: While the interrupting effect of SD was not as pronounced as anticipated, this study did validate the effectiveness of SD in modifying health behaviors and minimizing avoidable visits to EDs in addition to curtailing the occurrence of infectious diseases.PMID:38653569 | DOI:10.3349/ymj.2023.0135 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Minseo Choi Mia Son Sanghyuk Bae Whanhee Lee Kyung-Nam Kim Jung K Hyun Source Type: research
E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population
This study was conducted on 200 participants who were admitted to the surgical specialty hospital-cardiac center in Erbil City, Iraq between October 2021 and May 2022. Based on the outcomes of the clinical examination, laboratory tests, coronary angiography (COA), acute myocardial infarction (MI) type ST-elevation myocardial infarction (STEMI), stable angina pectoris (SAP), and healthy control groups were tested. Each sample was subjected to Sanger sequencing. The polymorphism was significantly linked to stable angina and myocardial infarction Genotype CC was higher in SAP when compared with MI and control groups which was...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Lajan Qasim Rahman Ruqaya Muhammad Ghareeb Source Type: research
ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):125-129. doi: 10.14715/cmb/2024.70.3.18.ABSTRACTMyocardial ischemia/reperfusion injury (MIRI) is an irreversible adverse event during the management of coronary heart disease that lacks effective controls. The underlying mechanism of MIRI still requires further investigation. Recent studies have suggested that overexpression of ATF3 protects against MIRI by regulating inflammatory responses, ferroptosis, and autophagy. The downstream target of ATF3, EGR1, also showed cardioprotective properties against MIRI by promoting autophagy. Therefore, further investigating the effect...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Li Li Gang Fu Caiyun Liu Yanling Liu Source Type: research
Early and Long-Term Results of Simultaneous and Staged Revascularization of Coronary and Carotid Arteries
CONCLUSIONS: This study revealed no significant difference in the impact of simultaneous CABG + CEA or staged CABG/CEA on the incidence of death, stroke, MI, and MACEs over a 30-day and long-term follow-up period. Although the immediate results indicated an increased risk of a complicated course (attributable to overall complications) and more prolonged ventilation after simultaneous CABG + CEA compared with staged CABG/CEA, this did not lead to an increase in fatal complications. Therefore, the implementation of either tactic is considered eligible and appropriate following a thorough operative risk assessment.PMID:386514...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Elena Golukhova Igor Sigaev Milena Keren Inessa Slivneva Bektur Berdibekov Nina Sheikina Olga Kozlova Valery Arakelyan Irina Volkovskaya Tatiana Zavalikhina Susanna Avakova Source Type: research
Clinical Value of the Diagonal Earlobe Crease in Patients with Chest Pain for Diagnosing Coronary Heart Disease
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 23, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Very short sleep duration reveals a proteomic fingerprint that is selectively associated with incident diabetes mellitus but not with incident coronary heart disease: a cohort study
The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns as... (Source: BMC Medicine)
Source: BMC Medicine - April 23, 2024 Category: Internal Medicine Authors: Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Gunnar Engstr öm, Jan Nilsson, Marju Orho-Melander, Peter M. Nilsson and Olle Melander Tags: Research article Source Type: research
Fetal transposition of the great arteries: 3D virtual and physical models from ultrasound datasets
AbstractTransposition of the great arteries (TGA) is a cyanotic congenital heart disease characterized by ventriculoarterial discordance and atrioventricular concordance with the great arteries in a parallel relationship. Prenatal diagnosis of TGA has implications for postnatal outcomes, allowing for planned delivery and perinatal management. Three-dimensional virtual or physical models of fetal TGA allow better understanding of fetal cardiac anomalies by parents and interactive discussion among the multidisciplinary team (obstetricians, pediatricians, maternal-fetal specialists, pediatric cardiologists, and cardiovascular...
Source: The International Journal of Cardiovascular Imaging - April 23, 2024 Category: Radiology Source Type: research
Intracoronary physiology: Easier to measure, but still complex. The art of interpreting intracoronary pressure wire data.
Since the introduction of fractional flow reserve (FFR) [1], coronary physiology has progressively gained prominence in coronary diagnosis and intervention. Its implementation has led to improved outcomes, safely avoiding unnecessary revascularisations without increasing or even decreasing the number of adverse events. Recently, FFR has facilitated a new approach to understanding ischemic heart disease, explaining its symptoms and consequences beyond coronary stenoses [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 23, 2024 Category: Cardiology Authors: Ram ón López-Palop, Pilar Carrillo, Alfonso Freites Source Type: research
