A Novel Artificial Coronary Plaque to Model Coronary Heart Disease
CONCLUSION: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.PMID:38667208 | PMC:PMC11048636 | DOI:10.3390/biomimetics9040197 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Philipp Lindenhahn Jannik Richter Iliyana Pepelanova Bettina Seeger Holger A Volk Rabea Hinkel Bernhard Hiebl Thomas Scheper Jan B Hinrichs Lena S Becker Axel Haverich Tim Kaufeld Source Type: research
Comparison of four predictive scores for cardiovascular risk in Mexican people living with HIV
This study aimed to assess the agreement between different predictive CVR scores and explore their relationship with clinical and demographic data in Mexican PWH. A descriptive cross-sectional analysis was conducted in 200 PWH with a mean age of 42 years who were treated at a Mexican urban center from 2017 to 2018. The majority (83%) were on antiretroviral treatment and 79.5% had undetectable viral loads. Moderate-to-high risk scores were infrequent, with Framingham Risk Score for Hard Coronary Heart Disease (FRS-HCHD) scores showing higher values, with very low concordance among all scores. Logistic regression analysis re...
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Pablo Franco Oliva-S ánchez Salvador Landeros-L ópez Maria Margarita Rosas-Dossetti Samuel Grobeisen-Levin Jorge Alberto Islas-Mart ínez Daniel Aznar-Guerra Aneth Paola Valdez-Celiz Luis Soto-Ramirez Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Important molecular mechanisms in ferroptosis
Mol Cell Biochem. 2024 Apr 26. doi: 10.1007/s11010-024-05009-w. Online ahead of print.ABSTRACTFerroptosis is a type of cell death that is caused by the oxidation of lipids and is dependent on the presence of iron. It was first characterized by Brent R. Stockwell in 2012, and since then, research in the field of ferroptosis has rapidly expanded. The process of ferroptosis-induced cell death is genetically, biochemically, and morphologically distinct from other forms of cellular death, such as apoptosis, necroptosis, and non-programmed cell death. Extensive research has been devoted to comprehending the intricate process of ...
Source: Molecular and Cellular Biochemistry - April 26, 2024 Category: Biochemistry Authors: Lunmeng Lai Menglei Tan Mingming Hu Xiyue Yue Lulu Tao Yanru Zhai Yunsen Li Source Type: research
Unravelling the role of cathepsins in cardiovascular diseases
Mol Biol Rep. 2024 Apr 26;51(1):579. doi: 10.1007/s11033-024-09518-1.ABSTRACTLysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as abdominal aortic aneurysm, hypertension, cardiomyopathy, coronary heart disease, atherosclerosis, etc. They are ubiquitous lysosomal proteases with papain-like folded protein structures that are involved in a variety of physiological processes, such as the digestion of proteins, activation of pro-inflammatory molecules, degradation of extracellular matrix components, and maturation of peptide hormone...
Source: Molecular Biology Reports - April 26, 2024 Category: Molecular Biology Authors: Sonali Maheshwari Bhoomika M Patel Source Type: research
Role of cyclophilin A in aggravation of myocardial ischemia reperfusion injury via regulation of apoptosis mediated by thioredoxin-interacting protein
CONCLUSION: These findings highlight the critical role CypA plays in myocardial injury caused by oxidative stress-induced apoptosis, indicating that CypA can be a viable biomarker and a therapeutic target candidate for MI/RI.PMID:38669522 | DOI:10.3233/CH-242142 (Source: Work)
Source: Work - April 26, 2024 Category: Occupational Health Authors: Madina Mahesutihan Ju Yan Hasidaer Midilibieke Li Yu Reyizha Dawulin Wen-Xian Yang Muhuyati Wulasihan Source Type: research
Cardiovascular Risk Associated With Social Determinants of Health at Individual and Area Levels
CONCLUSIONS AND RELEVANCE: In this cohort study, both individual- and area-level SDOH were associated with ASCVD risk; adding both individual- and area-level SDOH to the PCEs modestly improved discrimination and calibration for estimating ASCVD risk for Black individuals, and adding individual-level SDOH to PREVENT plus SDI also modestly improved calibration. These findings suggest that both individual- and area-level SDOH may be considered in future development of ASCVD risk assessment tools, particularly among Black individuals.PMID:38669015 | DOI:10.1001/jamanetworkopen.2024.8584 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Mengying Xia Jaejin An Monika M Safford Lisandro D Colantonio Mario Sims Kristi Reynolds Andrew E Moran Yiyi Zhang Source Type: research
Unravelling the role of cathepsins in cardiovascular diseases
Mol Biol Rep. 2024 Apr 26;51(1):579. doi: 10.1007/s11033-024-09518-1.ABSTRACTLysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as abdominal aortic aneurysm, hypertension, cardiomyopathy, coronary heart disease, atherosclerosis, etc. They are ubiquitous lysosomal proteases with papain-like folded protein structures that are involved in a variety of physiological processes, such as the digestion of proteins, activation of pro-inflammatory molecules, degradation of extracellular matrix components, and maturation of peptide hormone...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Sonali Maheshwari Bhoomika M Patel Source Type: research
A Novel Artificial Coronary Plaque to Model Coronary Heart Disease
CONCLUSION: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.PMID:38667208 | DOI:10.3390/biomimetics9040197 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Philipp Lindenhahn Jannik Richter Iliyana Pepelanova Bettina Seeger Holger A Volk Rabea Hinkel Bernhard Hiebl Thomas Scheper Jan B Hinrichs Lena S Becker Axel Haverich Tim Kaufeld Source Type: research
Maternal cardiovascular health in early pregnancy and the risk of congenital heart defects in offspring
This study aimed to explore the association between maternal cardiovascular health (CVH) and the CHD risk in offspring. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 26, 2024 Category: OBGYN Authors: Dan-wei Zhang, Yi-bing Zhu, Si-jia Zhou, Xiu-hua Chen, Hai-bo Li, Wen-juan Liu, Zheng-qin Wu, Qiang Chen and Hua Cao Tags: Research Source Type: research
Could a rare mutation that causes dwarfism also slow ageing?
Nature, Published online: 26 April 2024; doi:10.1038/d41586-024-01201-6People with Laron syndrome have a low risk of heart disease and a number of other age-related disorders, hinting at strategies for new treatments. (Source: Nature AOP)
Source: Nature AOP - April 26, 2024 Category: Research Authors: Mariana Lenharo Source Type: research
A gene mutation turned these fish into intrepid explorers
The 240 species of cichlid fish in Africa’s Lake Tanganyika come in an astonishing variety of shapes and sizes, from the paper clip–size “sheller” that lives in abandoned snail shells to the nearly meter-long emperor cichlid. Biologists have long wondered what drove this burst of evolutionary creativity. Now, researchers have demonstrated what many suspected but had not been able to prove: that the behavior of an ancestral species—in this case, an appetite for exploration—set the stage for the rapid evolution.
The work, which appears today in
Science
, also
ties this behavioral trait to a...
Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
Can science find ways to ease loneliness?
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Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
Temporal trend in mortality due to congenital heart disease in China from 2008 to 2021
CONCLUSIONS: CHD mortality in China has dramatically decreased from 2008 to 2021. The slower decrease in CHD mortality in the central and western regions than in the eastern regions suggested that public health policymakers should pay more attention to health resources and health education for central and western regions.PMID:38663857 | DOI:10.1097/CM9.0000000000003057 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 25, 2024 Category: General Medicine Authors: Youping Tian Xiaojing Hu Qing Gu Miao Yang Pin Jia Xiaojing Ma Xiaoling Ge Quming Zhao Fang Liu Ming Ye Weili Yan Guoying Huang Source Type: research
Temporal trend in mortality due to congenital heart disease in China from 2008 to 2021
CONCLUSIONS: CHD mortality in China has dramatically decreased from 2008 to 2021. The slower decrease in CHD mortality in the central and western regions than in the eastern regions suggested that public health policymakers should pay more attention to health resources and health education for central and western regions.PMID:38663857 | DOI:10.1097/CM9.0000000000003057 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 25, 2024 Category: General Medicine Authors: Youping Tian Xiaojing Hu Qing Gu Miao Yang Pin Jia Xiaojing Ma Xiaoling Ge Quming Zhao Fang Liu Ming Ye Weili Yan Guoying Huang Source Type: research
