The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease
Clin Immunol. 2024 Mar 7:110178. doi: 10.1016/j.clim.2024.110178. Online ahead of print.ABSTRACTControlling the excessive inflammatory response is one of the key ways to reduce the severity and mortality of severe influenza virus infections. RAGE is involved in inflammatory responses and acute lung injuries. Here, we investigated the role of RAGE and its potential application as a target for severe influenza treatment through serological correlation analysis for influenza patients, and treatment with the RAGE inhibitor FPS-ZM1 on A549 cells or mice with influenza A (H1N1) infection. The results showed high levels of RAGE w...
Source: Clinical Immunology - March 9, 2024 Category: Allergy & Immunology Authors: Wenhui Guo Junhao Luo Song Zhao Li Li Wenge Xing Rongbao Gao Source Type: research
The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease
Clin Immunol. 2024 Mar 7:110178. doi: 10.1016/j.clim.2024.110178. Online ahead of print.ABSTRACTControlling the excessive inflammatory response is one of the key ways to reduce the severity and mortality of severe influenza virus infections. RAGE is involved in inflammatory responses and acute lung injuries. Here, we investigated the role of RAGE and its potential application as a target for severe influenza treatment through serological correlation analysis for influenza patients, and treatment with the RAGE inhibitor FPS-ZM1 on A549 cells or mice with influenza A (H1N1) infection. The results showed high levels of RAGE w...
Source: Clinical Immunology - March 9, 2024 Category: Allergy & Immunology Authors: Wenhui Guo Junhao Luo Song Zhao Li Li Wenge Xing Rongbao Gao Source Type: research
Omics-based profiles and biomarkers of respiratory infections: are we there yet?
Extract
From the influenza pandemic of 1918–1919 to the most recent COVID-19 pandemic, respiratory infections remain a leading cause of mortality worldwide [1, 2]. Concurrently, the development of high-throughput omics technologies has revolutionised research about host responses to known and emerging respiratory pathogens [3], accelerating our understanding of highly prevalent pulmonary diseases [4]. Notably, omics technology-based characterisation of pathogens and host pathophysiology have critically supported diagnostic and therapeutic global health efforts during both the influenza A H1N1 and SARS-CoV-2 pandemics...
Source: European Respiratory Journal - March 7, 2024 Category: Respiratory Medicine Authors: Pantaleon Garcia, J., Evans, S. E. Tags: Editorials Source Type: research
Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies
CONCLUSIONS It seems important to determine whether the influenza virus strains tested for drug resistance as part of global influenza surveillance are equally representative of viruses circulating in populations with high and low vaccination rates, for all countries. Our results suggest that countries with low levels of influenza immunization may constitute reservoirs of drug-resistant influenza viruses.PMID:38446736 | DOI:10.12659/MSM.942125 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 6, 2024 Category: Research Authors: Ewelina Hallmann Aleksander Masny Anna Pozna ńska Francisco Pozo Inmaculada Casas Lidia Bernadeta Brydak Source Type: research
Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
Non-pharmaceutical interventions implemented during the COVID-19 pandemic resulted in a marked reduction in influenza infections globally. The absence of influenza has raised concerns of waning immunity, and p... (Source: Virology Journal)
Source: Virology Journal - March 6, 2024 Category: Virology Authors: Even Fossum, Andreas Rohringer, Torstein Aune, Kjersti Margrethe Rydland, Karoline Bragstad and Olav Hungnes Tags: Research Source Type: research
A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno ‐Stimulating Effects
In this study, an immuno-stimulating antiviral system (ISAS) is introduced, which is composed of the immuno-stimulating adjuvant lipopeptide Pam3CSK4 that acts as a scaffold onto which it is covalently bound 3 to 4 influenza-inhibiting peptides. The multivalent display of peptides on the scaffold leads to a potent inhibition against H1N1 (EC50 = 20 nM). Importantly, the resulting lipopeptide, Pam3FDA, shows an irreversible inhibition mechanism. The chemical modification of peptides on the scaffold maintains Pam3CSK4's ability to stimulate dendritic cell maturation, thereby rendering Pam3FDA a unique antiviral. This is...
Source: Small - March 5, 2024 Category: Nanotechnology Authors: Yong Zhu,
Lixia Wei,
Arnaud Charles ‐Antoine Zwygart,
Pablo Gaínza,
Quy Ong Khac,
Francesca Olgiati,
Armand Kurum,
Li Tang,
Bruno Correia,
Caroline Tapparel,
Francesco Stellacci Tags: Research Article Source Type: research
Influenza a H1N1 infection complicated with encephalopathy and acute pancreatitis: a case report
This paper reports a case of influenza complicated with influenza associated encephalopathy complicated with acute pancreatitis. This kind of disease is relatively rare, we hope to draw people ’s attention to i... (Source: BMC Pediatrics)
Source: BMC Pediatrics - March 5, 2024 Category: Pediatrics Authors: Junhao Cui, Wanyu Jia, Peng Li, Xue Zhang, Zheng Li and Chunlan Song Tags: Case Report Source Type: research
Viruses, Vol. 16, Pages 388: Impact of the H274Y Substitution on N1, N4, N5, and N8 Neuraminidase Enzymatic Properties and Expression in Reverse Genetic Influenza A Viruses
In conclusion, the H274Y-NA substitution of different group-1-NAs systematically reduced their affinity for MUNANA substrate without a significant impact on NA Vm. The impact of the H274Y-NA substitution on viral NA expression was different according to the studied NA. (Source: Viruses)
Source: Viruses - March 1, 2024 Category: Virology Authors: Alexandre Gaymard Caroline Picard Guilhem Vazzoler Pascale Massin Emilie Frobert Murielle Sabatier Mendy Barthelemy Martine Valette Mich èle Ottmann Jean-S ébastien Casalegno Bruno Lina Vanessa Escuret Tags: Communication Source Type: research
Real-world effectiveness of seasonal influenza vaccination and age as effect modifier: A systematic review, meta-analysis and meta-regression of test-negative design studies
CONCLUSIONS: Influenza vaccines provided moderate protection against laboratory-confirmed influenza and related outpatient visit and hospitalization. However, the effectiveness may vary substantially by virus type and age group, suggesting the necessity to tailor vaccination strategies especially for older individuals and against the A/H3N2 strain, and to promote annual immunization and annual analysis of vaccine effectiveness.PMID:38423813 | DOI:10.1016/j.vaccine.2024.02.059 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: Jinxin Guo Xin Chen Yu Guo Mengze Liu Pei Li Yiming Tao Zhike Liu Zhirong Yang Siyan Zhan Feng Sun Source Type: research
Immunogenicity and safety of a quadrivalent recombinant influenza vaccine manufactured in Iran (FluGuard) in volunteers aged 18-60 years: A double-blind, non-inferiority, randomized controlled trial
CONCLUSION: Our findings support the non-inferiority of the FluGuard vaccine to the Vaxigrip vaccine regarding immunogenicity and safety.CLINICAL TRIAL REGISTRY: The study protocol was approved by the Iranian Registry of Clinical Trials (IRCT20210901052358N5).PMID:38423811 | DOI:10.1016/j.vaccine.2024.02.073 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: Davood Yadegarynia Amirreza Keyvanfar Hossein Keyvani Shabnam Tehrani Shahnaz Sali Sara Abolghasemi Source Type: research
Real-world effectiveness of seasonal influenza vaccination and age as effect modifier: A systematic review, meta-analysis and meta-regression of test-negative design studies
CONCLUSIONS: Influenza vaccines provided moderate protection against laboratory-confirmed influenza and related outpatient visit and hospitalization. However, the effectiveness may vary substantially by virus type and age group, suggesting the necessity to tailor vaccination strategies especially for older individuals and against the A/H3N2 strain, and to promote annual immunization and annual analysis of vaccine effectiveness.PMID:38423813 | DOI:10.1016/j.vaccine.2024.02.059 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: Jinxin Guo Xin Chen Yu Guo Mengze Liu Pei Li Yiming Tao Zhike Liu Zhirong Yang Siyan Zhan Feng Sun Source Type: research
Immunogenicity and safety of a quadrivalent recombinant influenza vaccine manufactured in Iran (FluGuard) in volunteers aged 18-60 years: A double-blind, non-inferiority, randomized controlled trial
CONCLUSION: Our findings support the non-inferiority of the FluGuard vaccine to the Vaxigrip vaccine regarding immunogenicity and safety.CLINICAL TRIAL REGISTRY: The study protocol was approved by the Iranian Registry of Clinical Trials (IRCT20210901052358N5).PMID:38423811 | DOI:10.1016/j.vaccine.2024.02.073 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: Davood Yadegarynia Amirreza Keyvanfar Hossein Keyvani Shabnam Tehrani Shahnaz Sali Sara Abolghasemi Source Type: research
Plitidepsin as an Immunomodulator against Respiratory Viral Infections
J Immunol. 2024 Feb 28:ji2300426. doi: 10.4049/jimmunol.2300426. Online ahead of print.ABSTRACTPlitidepsin is a host-targeted compound known for inducing a strong anti-SARS-CoV-2 activity, as well as for having the capacity of reducing lung inflammation. Because IL-6 is one of the main cytokines involved in acute respiratory distress syndrome, the effect of plitidepsin in IL-6 secretion in different in vitro and in vivo experimental models was studied. A strong plitidepsin-mediated reduction of IL-6 was found in human monocyte-derived macrophages exposed to nonproductive SARS-CoV-2. In resiquimod (a ligand of TLR7/8)-stimu...
Source: Journal of Immunology - February 28, 2024 Category: Allergy & Immunology Authors: Alejandro Losada Nuria Izquierdo-Useros Pablo Aviles J úlia Vergara-Alert Irene Latino Joaquim Segal és Santiago F Gonzalez Carmen Cuevas D àlia Raïch-Regué Mar ía J Muñoz-Alonso Daniel Perez-Zsolt Jordana Mu ñoz-Basagoiti Jordi Rodon Lauren A Cha Source Type: research
Plitidepsin as an Immunomodulator against Respiratory Viral Infections
J Immunol. 2024 Feb 28:ji2300426. doi: 10.4049/jimmunol.2300426. Online ahead of print.ABSTRACTPlitidepsin is a host-targeted compound known for inducing a strong anti-SARS-CoV-2 activity, as well as for having the capacity of reducing lung inflammation. Because IL-6 is one of the main cytokines involved in acute respiratory distress syndrome, the effect of plitidepsin in IL-6 secretion in different in vitro and in vivo experimental models was studied. A strong plitidepsin-mediated reduction of IL-6 was found in human monocyte-derived macrophages exposed to nonproductive SARS-CoV-2. In resiquimod (a ligand of TLR7/8)-stimu...
Source: Journal of Immunology - February 28, 2024 Category: Allergy & Immunology Authors: Alejandro Losada Nuria Izquierdo-Useros Pablo Aviles J úlia Vergara-Alert Irene Latino Joaquim Segal és Santiago F Gonzalez Carmen Cuevas D àlia Raïch-Regué Mar ía J Muñoz-Alonso Daniel Perez-Zsolt Jordana Mu ñoz-Basagoiti Jordi Rodon Lauren A Cha Source Type: research
Immunogenicity of chimeric hemagglutinins delivered by an orf virus vector platform against swine influenza virus
Orf virus (ORFV) is a large DNA virus that can harbor and efficiently deliver viral antigens in swine. Here we used ORFV as a vector platform to deliver chimeric hemagglutinins (HA) of Influenza A virus of swine (IAV-S). Vaccine development against IAV-S faces limitations posed by strain-specific immunity and the antigenic diversity of the IAV-S strains circulating in the field. A promising alternative aiming at re-directing immune responses on conserved epitopes of the stalk segment of the hemagglutinin (HA2) has recently emerged. Sequential immunization with chimeric HAs comprising the same stalk but distinct exotic head...
Source: Frontiers in Immunology - February 28, 2024 Category: Allergy & Immunology Source Type: research
