Lessons learned from COVID-19, H1N1, and routine vaccine pharmacovigilance in the United States: a path to a more robust vaccine safety program
Expert Opin Drug Saf. 2024 Feb;23(2):161-175. doi: 10.1080/14740338.2024.2305707. Epub 2024 Feb 11.ABSTRACTINTRODUCTION: Vaccine pharmacovigilance is an essential component of vaccine safety programs. Vaccine pharmacovigilance refers to detecting uncommon adverse events following immunization (AEFI), determining whether they are due to the vaccine or are only a coincidence, and, for those AEFI considered related to vaccination, characterizing them further. When AEFI are due to vaccination, it is important to characterize the attributable risk and ascertain the biological mechanism causing the adverse reaction to inform eff...
Source: Expert Opinion on Drug Safety - February 12, 2024 Category: Drugs & Pharmacology Authors: Daniel A Salmon Robert T Chen Steve Black Joshua Sharfstein Source Type: research
Influenza vaccination during the 2021/22 season: A data-linkage test-negative case-control study of effectiveness against influenza requiring emergency care in England and serological analysis of primary care patients
We present England 2021/22 end-of-season adjusted vaccine effectiveness (aVE) against laboratory confirmed influenza related emergency care use in children aged 1-17 and in adults aged 50+, and serological findings in vaccinated vs unvaccinated adults by hemagglutination inhibition assay. Influenza vaccination has been routinely offered to all children aged 2-10 years and adults aged 65 years + in England. In 2021/22, the offer was extended to children to age 15 years, and adults aged 50-64 years. Influenza activity rose during the latter half of the 2021/22 season, while remaining comparatively low due to COVID-19 pandemi...
Source: Vaccine - February 11, 2024 Category: Allergy & Immunology Authors: Heather J Whitaker Katie Hassell Katja Hoschler Linda Power Julia Stowe Nicki L Boddington Camille Tsang Hongxin Zhao Ezra Linley Elizabeth Button Cecilia Okusi Carole Aspden Rachel Byford Simon deLusignan Gayatri Amirthalingam Maria Zambon Nick J Andrews Source Type: research
Isolation and characterization of genotype 4 Eurasian avian-like H1N1 influenza virus in pigs suffering from pneumonia
Virology. 2024 Feb 2;592:110009. doi: 10.1016/j.virol.2024.110009. Online ahead of print.ABSTRACTSwine influenza viruses pose ongoing threat to pork industry throughout the world. In 2023, fattening pigs from a swine farm in Inner Mongolia of China experienced influenza-like symptoms. Co-infection of influenza A virus with Pasteurella multocida was diagnosed in lung tissues of diseased pigs and a genotype 4 (G4) Eurasian avian-like (EA) H1N1 virus was isolated, which was named as A/swine/Neimenggu/0326/2023. We demonstrated the virus preferentially bound human-like SAα2,6Gal receptor. It was noteworthy that the virus poss...
Source: Virology - February 8, 2024 Category: Virology Authors: Jizhe Yang Riguo Lan Haoyu Chang Han Li Haili Yu Qi Tong Jinhua Liu Honglei Sun Source Type: research
Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition of nucleic acid synthesis, mRNA splicing, and protein stability
Volume 15, Issue 1, December 2024 . (Source: Virulence)
Source: Virulence - February 6, 2024 Category: Virology Authors: Xin WangFeiyang PuXuanye YangXili FengJiayou ZhangKai DuanXuanxuan NianZhongren MaXiao-Xia MaXiao-Ming Yanga Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lan Source Type: research
The lingering challenge: addressing vaccine hesitancy in a post-pandemic world
This article discusses the role of anti-vaxxers and vaccine-hesitant groups, electronic social media, and politics in vaccine hesitancy among people. It describes the strategies to combat the roadblocks in the vaccination programmes and health benefits, offered by recent advances in scientific and technological developments.PMID:38309708 | DOI:10.21101/cejph.a7593 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - February 3, 2024 Category: International Medicine & Public Health Authors: Ethan Ayaan Mir Source Type: research
