Microstructural White Matter Abnormalities in Children and Adolescents With Narcolepsy Type 1
In 2010, the H1N1 Pandemrix vaccination campaign was followed by a sudden increase in narcolepsy type 1 (NT1). We investigated the brain white matter microstructure in children with onset of NT1 within two years after the Pandemrix vaccination. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 11, 2024 Category: Neurology Authors: Marita Hovi, Ulrika Roine, Taina Autti, Hannu Heiskala, Timo Roine, Turkka Kirjavainen Tags: Research Paper Source Type: research
Self-adjuvant multiepitope nanovaccine based on ferritin induced long-lasting and effective mucosal immunity against H3N2 and H1N1 viruses in mice
Int J Biol Macromol. 2024 Jan 6:129259. doi: 10.1016/j.ijbiomac.2024.129259. Online ahead of print.ABSTRACTThe influenza A virus (IAV) is a ubiquitous and continuously evolving respiratory pathogen. The intranasal vaccination mimicking natural infections is an attractive strategy for controlling IAVs. Multiepitope vaccines accurately targeting multiple conserved domains have the potential to broaden the protective scope of current seasonal influenza vaccines and reduce the risk of generating escape mutants. Here, multiple linear epitopes from the matrix protein 2 ectodomain (M2e) and the hemagglutinin stem domain (HA2) are...
Source: International Journal of Biological Macromolecules - January 8, 2024 Category: Biochemistry Authors: Jiaojiao Nie Yongfei Zhou Fan Ding Xiaoxi Liu Xin Yao Lipeng Xu Yaotian Chang Zeyu Li Qingyu Wang Li Zhan Lvzhou Zhu Kunpeng Xie Chenxi Li Yuhua Shi Qi Zhao Yaming Shan Source Type: research
Zoonosis and zooanthroponosis of emerging respiratory viruses
Lung infections in Influenza-Like Illness (ILI) are triggered by a variety of respiratory viruses. All human pandemics have been caused by the members of two major virus families, namely Orthomyxoviridae (influenza A viruses (IAVs); subtypes H1N1, H2N2, and H3N2) and Coronaviridae (severe acute respiratory syndrome coronavirus 2, SARS−CoV−2). These viruses acquired some adaptive changes in a known intermediate host including domestic birds (IAVs) or unknown intermediate host (SARS-CoV-2) following transmission from their natural reservoirs (e.g. migratory birds or bats, respectively). Verily, these acquired adaptive su...
Source: Frontiers in cellular and infection microbiology - January 5, 2024 Category: Microbiology Source Type: research
Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice
AbstractAlthough zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with supplemental zinc) for such a role in lower respiratory tract infection are somewhat ambiguous. In the current study, we provide the first preclinical evidence demonstrating that although diet-induced acute zinc deficiency (Zn-D: ~50% decrease) did not worsen infection induced by either influenza A (H1N1) or methicillin-resistant staph aureus (MRSA), Zn-D mice were sensitive t...
Source: Physiological Reports - January 2, 2024 Category: Physiology Authors: Radha Gopal,
Egemen Tutuncuoglu,
Veli Bakalov,
Karla Wasserloos,
HuiHua Li,
David Lemley,
Louis J. DeVito,
Nicholas J. Constantinesco,
Douglas S. Reed,
Kevin J. McHugh,
Baskaran Chinnappan,
Alexis R. Andreas,
Abigail Maloy,
Daniel Bain,
John Tags: ORIGINAL ARTICLE Source Type: research
CD46 inhibits the replication of swine influenza viruses by promoting the production of type I IFNs in PK-15 cells
AbstractSwine flu caused by swine influenza A virus (swIAV) is an acute respiratory viral disease that is spreading in swine herds worldwide. Although the effect of some host factors on replication of swIAV has been identified, the role of CD46 in this process is unclear. Here, we report that CD46 inhibits the replication of swIAV by promoting the production of type I interferons (IFNs) in porcine kidney (PK-15) cells. CD46 knockout (CD46-KO) and stably expressing (CD46-overexpression) PK-15 cells were prepared using lentivirus-mediated CRISPR/Cas9 gene editing and seamless cloning technology. The results of virus infectio...
Source: Veterinary Research Communications - December 28, 2023 Category: Veterinary Research Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.ABSTRACTWe detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.PMID:38147510 | DOI:10.3201/eid3001.230756 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Pavithra Daulagala Samuel M S Cheng Alex Chin Leo L H Luk Kathy Leung Joseph T Wu Leo L M Poon Malik Peiris Hui-Ling Yen Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.ABSTRACTWe detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.PMID:38147510 | DOI:10.3201/eid3001.230756 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Pavithra Daulagala Samuel M S Cheng Alex Chin Leo L H Luk Kathy Leung Joseph T Wu Leo L M Poon Malik Peiris Hui-Ling Yen Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.ABSTRACTWe detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.PMID:38147510 | DOI:10.3201/eid3001.230756 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Pavithra Daulagala Samuel M S Cheng Alex Chin Leo L H Luk Kathy Leung Joseph T Wu Leo L M Poon Malik Peiris Hui-Ling Yen Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.ABSTRACTWe detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.PMID:38147510 | DOI:10.3201/eid3001.230756 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Pavithra Daulagala Samuel M S Cheng Alex Chin Leo L H Luk Kathy Leung Joseph T Wu Leo L M Poon Malik Peiris Hui-Ling Yen Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.ABSTRACTWe detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.PMID:38147510 | PMC:PMC10756388 | DOI:10.3201/eid3001.230756 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Pavithra Daulagala Samuel M S Cheng Alex Chin Leo L H Luk Kathy Leung Joseph T Wu Leo L M Poon Malik Peiris Hui-Ling Yen Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.ABSTRACTWe detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.PMID:38147510 | PMC:PMC10756388 | DOI:10.3201/eid3001.230756 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Pavithra Daulagala Samuel M S Cheng Alex Chin Leo L H Luk Kathy Leung Joseph T Wu Leo L M Poon Malik Peiris Hui-Ling Yen Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.ABSTRACTWe detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.PMID:38147510 | PMC:PMC10756388 | DOI:10.3201/eid3001.230756 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Pavithra Daulagala Samuel M S Cheng Alex Chin Leo L H Luk Kathy Leung Joseph T Wu Leo L M Poon Malik Peiris Hui-Ling Yen Source Type: research
Polyphenol rich sugarcane extract (PRSE) has potential antiviral activity against influenza A virus in vitro
In conclusion, we show that PRSE displays antiviral activity against a broad range of IAV strains, in vitro.PMID:38118269 | DOI:10.1016/j.virol.2023.109969 (Source: Virology)
Source: Virology - December 20, 2023 Category: Virology Authors: Caolingzhi Tang Julio Carrera Montoya Svenja Fritzlar Matthew Flavel Sarah L Londrigan Jason M Mackenzie Source Type: research
Polyphenol rich sugarcane extract (PRSE) has potential antiviral activity against influenza A virus in vitro
In conclusion, we show that PRSE displays antiviral activity against a broad range of IAV strains, in vitro.PMID:38118269 | DOI:10.1016/j.virol.2023.109969 (Source: Virology)
Source: Virology - December 20, 2023 Category: Virology Authors: Caolingzhi Tang Julio Carrera Montoya Svenja Fritzlar Matthew Flavel Sarah L Londrigan Jason M Mackenzie Source Type: research
Polyphenol rich sugarcane extract (PRSE) has potential antiviral activity against influenza A virus in vitro
In conclusion, we show that PRSE displays antiviral activity against a broad range of IAV strains, in vitro.PMID:38118269 | DOI:10.1016/j.virol.2023.109969 (Source: Virology)
Source: Virology - December 20, 2023 Category: Virology Authors: Caolingzhi Tang Julio Carrera Montoya Svenja Fritzlar Matthew Flavel Sarah L Londrigan Jason M Mackenzie Source Type: research
