Safety and immunogenicity of locally produced trivalent inactivated influenza vaccine (Tri Fluvac) in healthy Thai adults aged 18-64 years in Nakhon Phanom: A Phase III double blinded, three-arm, randomized, controlled trial
CONCLUSIONS: Tri Fluvac was well tolerated, and immunogenicity was non-inferior to the active comparator, meeting U.S. Food and Drug Administration (FDA) criteria for adult vaccine licensure. Few acute respiratory infections were reported during intense COVID-19 pandemic restrictions, resulting in insufficient power to evaluate clinical efficacy.PMID:38042698 | DOI:10.1016/j.vaccine.2023.11.050 (Source: Vaccine)
Source: Vaccine - December 2, 2023 Category: Allergy & Immunology Authors: Kriengkrai Prasert Prabda Praphasiri Hatairat Lerdsamran Sutthichai Nakphook Darunee Ditsungnoen Sutthinan Chawalchitiporn Kanlaya Sornwong Kittisak Poopipatpol Ponthip Wirachwong Piengthong Narakorn Somchaiya Surichan Nava Suthepakul Napawan Thangsupanim Source Type: research
Safety and immunogenicity of locally produced trivalent inactivated influenza vaccine (Tri Fluvac) in healthy Thai adults aged 18-64 years in Nakhon Phanom: A Phase III double blinded, three-arm, randomized, controlled trial
CONCLUSIONS: Tri Fluvac was well tolerated, and immunogenicity was non-inferior to the active comparator, meeting U.S. Food and Drug Administration (FDA) criteria for adult vaccine licensure. Few acute respiratory infections were reported during intense COVID-19 pandemic restrictions, resulting in insufficient power to evaluate clinical efficacy.PMID:38042698 | DOI:10.1016/j.vaccine.2023.11.050 (Source: Vaccine)
Source: Vaccine - December 2, 2023 Category: Allergy & Immunology Authors: Kriengkrai Prasert Prabda Praphasiri Hatairat Lerdsamran Sutthichai Nakphook Darunee Ditsungnoen Sutthinan Chawalchitiporn Kanlaya Sornwong Kittisak Poopipatpol Ponthip Wirachwong Piengthong Narakorn Somchaiya Surichan Nava Suthepakul Napawan Thangsupanim Source Type: research
Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid
CONCLUSION: Our supplemented CHG formulation showed immediate antiviral effectiveness, which is important for management of the infections. CHG can be combined with salicylic acid to exhibit synergistic antiviral activity at lower concentrations and reduce the time required for inactivation. Furthermore, in the presence of interfering substances, the combination has higher antiviral activity than CHG alone.PMID:38036721 | DOI:10.1007/s00705-023-05932-1 (Source: Herpes)
Source: Herpes - November 30, 2023 Category: Infectious Diseases Authors: Niloofar Jamshidinia Fatemeh Saadatpour Ehsan Arefian Fatemeh Mohammadipanah Source Type: research
Viruses, Vol. 15, Pages 2365: The Mobility of Eurasian Avian-like M2 Is Determined by Residue E79 Which Is Essential for Pathogenicity of 2009 Pandemic H1N1 Influenza Virus in Mice
In this study, it is found that the M2 protein of the (H1N1)pdm09 virus showed a lower mobility rate than the North America triple-reassortant influenza M2 protein in Polyacrylamide Gel Electrophoresis (PAGE). The site-directed mutations of the amino acids of (H1N1)pdm09 M2 revealed that E79 is responsible for the mobility rate change. Further animal studies showed that the (H1N1)pdm09 containing a single M2-E79K was significantly attenuated compared with the wild-type virus in mice and induced lower proinflammatory cytokines and IFNs in mouse lungs. Further in vitro studies indicated that this mutation also affected NLRP3...
Source: Viruses - November 30, 2023 Category: Virology Authors: Rujuan Wu Xinyu Zeng Mingqing Wu Lixiang Xie Guanlong Xu Yaqing Mao Zhaofei Wang Yuqiang Cheng Heng ’an Wang Yaxian Yan Jianhe Sun Jingjiao Ma Tags: Article Source Type: research
Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid
ConclusionOur supplemented CHG formulation showed immediate antiviral effectiveness, which is important for management of the infections. CHG can be combined with salicylic acid to exhibit synergistic antiviral activity at lower concentrations and reduce the time required for inactivation. Furthermore, in the presence of interfering substances, the combination has higher antiviral activity than CHG alone. (Source: Archives of Virology)
Source: Archives of Virology - November 30, 2023 Category: Virology Source Type: research
Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus
CONCLUSION: This is the first study that identified adequate immune protection against H3N2-influenza strain with additional vaccine-induced increment of immune response and an adequate safety profile in JSLE. ( www.CLINICALTRIALS: gov , NCT03540823).PMID:38017564 | DOI:10.1186/s42358-023-00339-7 (Source: Adv Data)
Source: Adv Data - November 29, 2023 Category: Epidemiology Authors: Nadia Emi Aikawa Eduardo Ferreira Borba Verena Andrade Balbi Adriana Maluf Elias Sallum Izabel Mantovani Buscatti Lucia Maria Arruda Campos K átia Tomie Kozu Cristiana Couto Garcia Artur Silva Vidal Cap ão Adriana Coracini Tonacio de Proen ça Elaine Pi Source Type: research
Viruses, Vol. 15, Pages 2300: Antiviral Potential of Azelastine against Major Respiratory Viruses
Valeria Szijarto
The Coronavirus Disease 2019 (COVID-19) pandemic and the subsequent increase in respiratory viral infections highlight the need for broad-spectrum antivirals to enable a quick and efficient reaction to current and emerging viral outbreaks. We previously demonstrated that the antihistamine azelastine hydrochloride (azelastine-HCl) exhibited in vitro antiviral activity against SARS-CoV-2. Furthermore, in a phase 2 clinical study, a commercial azelastine-containing nasal spray significantly reduced the viral load in SARS-CoV-2-infected individuals. Here, we evaluate the efficacy of azelastine-HCl agains...
Source: Viruses - November 23, 2023 Category: Virology Authors: Katrin Fischhuber Zolt án Bánki Janine Kimpel Natalie Kragl Annika R össler Annika Bolze Brigitte Muellauer Joachim Angerer G ábor Nagy Eszter Nagy Valeria Szijarto Tags: Article Source Type: research
Identification of potential antiviral compounds from Egyptian marine algae against influenza A virus
Nat Prod Res. 2023 Nov 22:1-8. doi: 10.1080/14786419.2023.2284865. Online ahead of print.ABSTRACTInfluenza is a contagious viral infection of the respiratory tract, affecting nearly 10% of the world's population, each year. The aim of this study was to extract and identify antiviral compounds against the influenza-A virus (H1N1) from different species of Egyptian marine algae. Three samples of marine macroalgae species were extracted and the antiviral activity of the extracts were tested on Madin Darby Canine Kidney cells. The bioactive compounds present in the most active fractions were identified using gas chromatography...
Source: Natural Product Research - November 22, 2023 Category: Biochemistry Authors: Bassel M Hassen Sarah H Rashedy Ahmed Mostafa Noura Mahrous Mohamed S Nafie Dalia Elebeedy A Z Abdel Azeiz Source Type: research
Identification of potential antiviral compounds from Egyptian marine algae against influenza A virus
Nat Prod Res. 2023 Nov 22:1-8. doi: 10.1080/14786419.2023.2284865. Online ahead of print.ABSTRACTInfluenza is a contagious viral infection of the respiratory tract, affecting nearly 10% of the world's population, each year. The aim of this study was to extract and identify antiviral compounds against the influenza-A virus (H1N1) from different species of Egyptian marine algae. Three samples of marine macroalgae species were extracted and the antiviral activity of the extracts were tested on Madin Darby Canine Kidney cells. The bioactive compounds present in the most active fractions were identified using gas chromatography...
Source: Natural Product Research - November 22, 2023 Category: Biochemistry Authors: Bassel M Hassen Sarah H Rashedy Ahmed Mostafa Noura Mahrous Mohamed S Nafie Dalia Elebeedy A Z Abdel Azeiz Source Type: research
Identification of potential antiviral compounds from Egyptian marine algae against influenza A virus
Nat Prod Res. 2023 Nov 22:1-8. doi: 10.1080/14786419.2023.2284865. Online ahead of print.ABSTRACTInfluenza is a contagious viral infection of the respiratory tract, affecting nearly 10% of the world's population, each year. The aim of this study was to extract and identify antiviral compounds against the influenza-A virus (H1N1) from different species of Egyptian marine algae. Three samples of marine macroalgae species were extracted and the antiviral activity of the extracts were tested on Madin Darby Canine Kidney cells. The bioactive compounds present in the most active fractions were identified using gas chromatography...
Source: Natural Product Research - November 22, 2023 Category: Biochemistry Authors: Bassel M Hassen Sarah H Rashedy Ahmed Mostafa Noura Mahrous Mohamed S Nafie Dalia Elebeedy A Z Abdel Azeiz Source Type: research
Monoglycosylated SARS-CoV-2 receptor binding domain fused with HA < sub > stem < /sub > -scaffolded protein vaccine confers broad protective immunity against SARS-CoV-2 and influenza viruses
This study demonstrated that HSSRmg produced using a monoglycosylation process and combined with the JR300 adjuvant elicits superior cross-strain immune responses against SARS-CoV-2 and influenza viruses in mice compared with S-2P. JR300-adjuvanted HSSRmg has great potential as a coronavirus-influenza vaccine that provides dual protection against SARS-CoV-2 and influenza infections.PMID:37984568 | DOI:10.1016/j.antiviral.2023.105759 (Source: Antiviral Research)
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Chia-Ying Wu Yung-Chieh Tseng Shao-En Kao Li-Yang Wu Jen-Tzu Hou Yu-Chih Yang Pei-Wen Hsiao Juine-Ruey Chen Source Type: research
Monoglycosylated SARS-CoV-2 receptor binding domain fused with HA < sub > stem < /sub > -scaffolded protein vaccine confers broad protective immunity against SARS-CoV-2 and influenza viruses
This study demonstrated that HSSRmg produced using a monoglycosylation process and combined with the JR300 adjuvant elicits superior cross-strain immune responses against SARS-CoV-2 and influenza viruses in mice compared with S-2P. JR300-adjuvanted HSSRmg has great potential as a coronavirus-influenza vaccine that provides dual protection against SARS-CoV-2 and influenza infections.PMID:37984568 | DOI:10.1016/j.antiviral.2023.105759 (Source: Antiviral Research)
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Chia-Ying Wu Yung-Chieh Tseng Shao-En Kao Li-Yang Wu Jen-Tzu Hou Yu-Chih Yang Pei-Wen Hsiao Juine-Ruey Chen Source Type: research
Monoglycosylated SARS-CoV-2 receptor binding domain fused with HA < sub > stem < /sub > -scaffolded protein vaccine confers broad protective immunity against SARS-CoV-2 and influenza viruses
This study demonstrated that HSSRmg produced using a monoglycosylation process and combined with the JR300 adjuvant elicits superior cross-strain immune responses against SARS-CoV-2 and influenza viruses in mice compared with S-2P. JR300-adjuvanted HSSRmg has great potential as a coronavirus-influenza vaccine that provides dual protection against SARS-CoV-2 and influenza infections.PMID:37984568 | DOI:10.1016/j.antiviral.2023.105759 (Source: Antiviral Research)
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Chia-Ying Wu Yung-Chieh Tseng Shao-En Kao Li-Yang Wu Jen-Tzu Hou Yu-Chih Yang Pei-Wen Hsiao Juine-Ruey Chen Source Type: research
An Observational Study on the Pharmacokinetics of Oseltamivir in Lactating Influenza Patients
Clin Pharmacol Ther. 2023 Nov 17. doi: 10.1002/cpt.3107. Online ahead of print.ABSTRACTInfluenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating women with acute influenza infection, and the consequent infant exposure to oseltamivir are still unknown, and these data would help in assessing risk and the need for dose adjustment in breastfed infants. Six lactating women with influenza-like symptoms, at a standard dose of 75 mg oral os...
Source: Clinical Pharmacology and Therapeutics - November 17, 2023 Category: Drugs & Pharmacology Authors: Eszter Fodor Regina N Nagy Andr ás Nógrádi Stephen Toovey Mohamed A Kamal P éter Vadász P éter Bencsik Anik ó Görbe P éter Ferdinandy Source Type: research
An Observational Study on the Pharmacokinetics of Oseltamivir in Lactating Influenza Patients
Clin Pharmacol Ther. 2023 Nov 17. doi: 10.1002/cpt.3107. Online ahead of print.ABSTRACTInfluenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating women with acute influenza infection, and the consequent infant exposure to oseltamivir are still unknown, and these data would help in assessing risk and the need for dose adjustment in breastfed infants. Six lactating women with influenza-like symptoms, at a standard dose of 75 mg oral os...
Source: Clinical Pharmacology and Therapeutics - November 17, 2023 Category: Drugs & Pharmacology Authors: Eszter Fodor Regina N Nagy Andr ás Nógrádi Stephen Toovey Mohamed A Kamal P éter Vadász P éter Bencsik Anik ó Görbe P éter Ferdinandy Source Type: research
