Viruses, Vol. 16, Pages 246: Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters
Caroline J. Zeiss
Seasonal infection rates of individual viruses are influenced by synergistic or inhibitory interactions between coincident viruses. Endemic patterns of SARS-CoV-2 and influenza infection overlap seasonally in the Northern hemisphere and may be similarly influenced. We explored the immunopathologic basis of SARS-CoV-2 and influenza A (H1N1pdm09) interactions in Syrian hamsters. H1N1 given 48 h prior to SARS-CoV-2 profoundly mitigated weight loss and lung pathology compared to SARS-CoV-2 infection alone. This was accompanied by the normalization of granulocyte dynamics and accelerated antigen-presenting...
Source: Viruses - February 3, 2024 Category: Virology Authors: Caterina Di Pietro Ann M. Haberman Brett D. Lindenbach Peter C. Smith Emanuela M. Bruscia Heather G. Allore Brent Vander Wyk Antariksh Tyagi Caroline J. Zeiss Tags: Article Source Type: research
“There's a little bit of mistrust”: Red River Métis experiences of the H1N1 and COVID‐19 pandemics
We examined the perspectives of the Red River M étis citizens in Manitoba, Canada, during the H1N1 and COVID-19 pandemics and how they interpreted the communication of government/health authorities’ risk management decisions. For Indigenous populations, pandemic response strategies play out within the context of ongoing colonial relationships with government institutions characterized by significant distrust. A crucial difference between the two pandemics was that the Métis in Manitoba were prioritized for early vaccine access during H1N1 but not for COVID-19. Data collection involved 17 focus groups with Métis citize...
Source: Risk Analysis - January 30, 2024 Category: International Medicine & Public Health Authors: S. Michelle Driedger,
Ryan Maier,
Gabriela Capurro,
Cindy Jardine,
Jordan Tustin,
Frances Chartrand,
Julianne Sanguins,
Olena Kloss Tags: ORIGINAL ARTICLE Source Type: research
Characteristics of two zoonotic swine influenza A(H1N1) viruses isolated in Germany from diseased patients
Int J Med Microbiol. 2024 Jan 24;314:151609. doi: 10.1016/j.ijmm.2024.151609. Online ahead of print.ABSTRACTInterspecies transmission of influenza A viruses (IAV) from pigs to humans is a concerning event as porcine IAV represent a reservoir of potentially pandemic IAV. We conducted a comprehensive analysis of two porcine A(H1N1)v viruses isolated from human cases by evaluating their genetic, antigenic and virological characteristics. The HA genes of those human isolates belonged to clades 1C.2.1 and 1C.2.2, respectively, of the A(H1N1) Eurasian avian-like swine influenza lineage. Antigenic profiling revealed substantial c...
Source: International Journal of Medical Microbiology - January 29, 2024 Category: Microbiology Authors: Alla Heider Marianne Wedde Viola Weinheimer Stephanie D öllinger Masyar Monazahian Ralf D ürrwald Thorsten Wolff Brunhilde Schweiger Source Type: research
Viruses, Vol. 16, Pages 201: Hypoxia and Activation of Neutrophil Degranulation-Related Genes in the Peripheral Blood of COVID-19 Patients
In this study, consensus gene dysregulation in the blood was obtained from 13 independent transcriptome studies on COVID-19. Among the up-regulated genes, the most prominent functional categories were neutrophil degranulation and cell cycle, which is clearly different from the classical activation of interferon signaling pathway in seasonal flu. As for the potential upstream causal factors of the atypical gene dysregulation, systemic hypoxia was further examined because it is much more widely reported in COVID-19 than that in seasonal flu. It was found that both physiological and pathological hypoxia can induce activation ...
Source: Viruses - January 28, 2024 Category: Virology Authors: Hongxing Lei Tags: Article Source Type: research
Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results
Antiviral Res. 2024 Feb;222:105818. doi: 10.1016/j.antiviral.2024.105818. Epub 2024 Jan 25.ABSTRACTIn this research, we employed a deep reinforcement learning (RL)-based molecule design platform to generate a diverse set of compounds targeting the neuraminidase (NA) of influenza A and B viruses. A total of 60,291 compounds were generated, of which 86.5 % displayed superior physicochemical properties compared to oseltamivir. After narrowing down the selection through computational filters, nine compounds with non-sialic acid-like structures were selected for in vitro experiments. We identified two compounds, DS-22-inf-009 a...
Source: Antiviral Research - January 27, 2024 Category: Virology Authors: Roza Izmailyan Mher Matevosyan Hamlet Khachatryan Anastasiya Shavina Smbat Gevorgyan Artur Ghazaryan Irina Tirosyan Yeva Gabrielyan Marusya Ayvazyan Boris Martirosyan Vardan Harutyunyan Hovakim Zakaryan Source Type: research
Age-dependent influenza infection patterns and subtype circulation in Denmark, in seasons 2015/16 to 2021/22
ConclusionThe 2021/22 influenza season had a different age distribution compared with pre-COVID-19 pandemic seasons.PMID:38275020 | DOI:10.2807/1560-7917.ES.2024.29.4.2300263 (Source: Euro Surveill)
Source: Euro Surveill - January 26, 2024 Category: Infectious Diseases Authors: Hanne-Dorthe Emborg Amanda Bolt Botnen Jens Nielsen Lasse S Vestergaard Frederikke Kristensen Lomholt Charlotte Munkstrup Karina Lauenborg M øller Charlotte Kjels ø Steen Hulthin Rasmussen Ramona Trebbien Source Type: research
Anti-microbial efficacy of a scientifically developed and standardized herbal-alcohol sanitizer
Arch Microbiol. 2024 Jan 25;206(2):77. doi: 10.1007/s00203-023-03805-4.ABSTRACTHands are the primary mode of transmission of microbe-based infections, as they harbor normal microbiota and pathogenic microbes. SARS-CoV-2 has endangered lives worldwide, and WHO has recommended good hygiene practices, especially hand hygiene. In addition, other infectious diseases like diphtheria, measles, tuberculosis, HIV, malaria, etc. are spreading in the shadow of the COVID-19 pandemic. The anti-microbial efficiency of two in-house developed herbal-alcohol based hand sanitizers containing Azadirachta indica, Citrus limon, Zingiber offici...
Source: Archives of Microbiology - January 25, 2024 Category: Microbiology Authors: Rajkumar Tulsawani Kalyani Verma Ekta Kohli Purva Sharma Yogesh Singh Meena None Amitabh Sarkaraisamy Ponmariappan Prashant Kumar Rekha Maithani Source Type: research
Age-dependent influenza infection patterns and subtype circulation in Denmark, in seasons 2015/16 to 2021/22
ConclusionThe 2021/22 influenza season had a different age distribution compared with pre-COVID-19 pandemic seasons. (Source: Eurosurveillance)
Source: Eurosurveillance - January 25, 2024 Category: Infectious Diseases Authors: Hanne-Dorthe Emborg, Amanda Bolt Botnen, Jens Nielsen, Lasse S. Vestergaard, Frederikke Kristensen Lomholt, Charlotte Munkstrup, Karina Lauenborg M øller, Charlotte Kjelsø, Steen Hulthin Rasmussen and Ramona Trebbien Source Type: research
Multiplex Detection of RNA Viruses Based on Ligation Reaction and Universal PCR Amplification
Curr Microbiol. 2024 Jan 23;81(3):75. doi: 10.1007/s00284-023-03582-9.ABSTRACTTo detect several RNA viruses simultaneously, a method based on multiplex ligation reaction combined with multiplex qPCR or multiplex PCR+capillary electrophoresis was established to detect four RNA viruses: human immunodeficiency virus (HIV), hepatitis C (HCV), influenza A virus (IAV) H1N1 and H5N1. The experimental conditions including ligation probe concentration, annealing procedure, ligation temperature and ligase dosage were optimized intensively. We found that the specificity of the ligation reaction was affected by the probe concentration...
Source: Current Microbiology - January 23, 2024 Category: Microbiology Authors: Lijun Qian Junhua Xiao Kai Li Yuxun Zhou Source Type: research
Influenza vaccine compatibility among hospitalized patients during and after the COVID-19 pandemic
This study compared circulating influenza A and B in hospitalized patients in Israel with the influenza strains in the vaccine following the 2021–2022 winter season which was dominated by the omicron variant.MethodsNasopharyngeal samples of 16,325 patients were examined for the detection of influenza A(H1N1)pdm09, influenza A(H1N1)pdm09 and influenza B. Phylogenetic trees of hemagglutinin were then prepared using sanger sequencing. Vaccine immunogenicity was also performed using the hemagglutination inhibition test.ResultsOf the 16,325 nasopharyngeal samples collected from hospitalized patients between September 2021 (We...
Source: Frontiers in Microbiology - January 23, 2024 Category: Microbiology Source Type: research
Comparison of geological clusters between influenza and COVID-19 in Thailand with unsupervised clustering analysis
In this study, unsupervised clustering techniques were used to identify clusters of disease trends in Thailand. The analysis inc orporated three distinct surveillance datasets: the pandemic influenza outbreak, influenza in the endemic stage, and the early stages of COVID-19. The analysis demonstrated a significant difference in the distribution of provinces between Cluster -1, representing those with unique transmission patte rns, and the other clusters, indicating provinces with similar transmission patterns among their members. Specifically, for Pandemic Influenza, the ratio was 61:16, while for Pandemic COVID-19, it was...
Source: PLoS One - January 22, 2024 Category: Biomedical Science Authors: Thanin Methiyothin Source Type: research
Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome
Int J Med Microbiol. 2024 Jan 11;314:151598. doi: 10.1016/j.ijmm.2024.151598. Online ahead of print.ABSTRACTRespiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized. A patient (age group 5-15 years) displaying symptoms of hemolytic uremic syndrome died one day after hospitalization. qPCR, next generation sequencing, virus isolation, antigenic characterization, resistance analysis was performed and virus replication kinetics in well-differentiated airway cells were determined. Autopsy revealed hemorrhagic pne...
Source: International Journal of Medical Microbiology - January 18, 2024 Category: Microbiology Authors: Yuguang Fu Marianne Wedde Sigrun Smola Djin-Ye Oh Thorsten Pfuhl J ürgen Rissland Michael Zemlin Fidelis A Flockerzi Rainer M Bohle Andrea Th ürmer Susanne Duwe Barbara Biere Janine Reiche Brunhilde Schweiger Christin Mache Thorsten Wolff Georg Herrler Source Type: research
