Viruses, Vol. 15, Pages 2264: Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses
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Takao Shishido
Influenza remains a worldwide health concern. Antiviral drugs are considered as one of the useful options for its prevention as a complementary measure to vaccination. Baloxavir acid selectively inhibits the cap-dependent endonuclease of influenza viruses and exhibits marked viral titre reduction in patients. Here, we describe the prophylactic potency of baloxavir acid against lethal infection with influenza A and B viruses in mice. BALB/c mice were subcutaneously administered once with baloxavir acid suspension, or orally administered once daily for 10 days with oseltamivir phosphate solution at hu...
Source: Viruses - November 16, 2023 Category: Virology Authors: Keita Fukao Takeshi Noshi Shinya Shano Kaoru Baba Kenji Sato Masashi Sakuramoto Naohisa Kitade Hideki Tanioka Shinji Kusakabe Takao Shishido Tags: Article Source Type: research
Reassortant H9N2 canine influenza viruses containing the pandemic H1N1/2009 ribonucleoprotein complex circulating in pigs acquired enhanced virulence in mice
This study generated 20 reassortant viruses with the introduction of H1N1/2009 internal genes from EA H1N1 virus into H9N2 virus. 12 of these recovered the replication capability both in the lungs and turbinate samples. 10 of 12 obtained PA gene segments from the ribonucleoprotein (RNP) complexes of the EA H1N1 virus, and 3 exhibited extreme virulence. Specially, the combination of PB2, PA and NP genes could overcome the species-specific restriction in human cells. Analysis of the polymerase activities found that introduction of the PA gene resulted in increased polymerase activity. These findings indicated that RNP comple...
Source: Virology - November 11, 2023 Category: Virology Authors: Min Zhu Hao Zeng Jianqiao He Yaohui Zhu Pingping Wang Jianing Guo Jinfan Guo Huabo Zhou Yifeng Qin Kang Ouyang Zuzhang Wei Weijian Huang Ying Chen Source Type: research
Reassortant H9N2 canine influenza viruses containing the pandemic H1N1/2009 ribonucleoprotein complex circulating in pigs acquired enhanced virulence in mice
This study generated 20 reassortant viruses with the introduction of H1N1/2009 internal genes from EA H1N1 virus into H9N2 virus. 12 of these recovered the replication capability both in the lungs and turbinate samples. 10 of 12 obtained PA gene segments from the ribonucleoprotein (RNP) complexes of the EA H1N1 virus, and 3 exhibited extreme virulence. Specially, the combination of PB2, PA and NP genes could overcome the species-specific restriction in human cells. Analysis of the polymerase activities found that introduction of the PA gene resulted in increased polymerase activity. These findings indicated that RNP comple...
Source: Virology - November 11, 2023 Category: Virology Authors: Min Zhu Hao Zeng Jianqiao He Yaohui Zhu Pingping Wang Jianing Guo Jinfan Guo Huabo Zhou Yifeng Qin Kang Ouyang Zuzhang Wei Weijian Huang Ying Chen Source Type: research
Two new Aspera chaetominines A and B, and a new derivative of terrein, isolated from marine sponge associated fungus < em > Aspergillus versicolour < /em > SCSIO XWS04 F52
Nat Prod Res. 2023 Nov 7:1-13. doi: 10.1080/14786419.2023.2275744. Online ahead of print.ABSTRACTTwo new alkaloids, Aspera chaetominines A (1) and B (2), a new derivative (3) of terrein, and together with 11 known compounds (4-14) were isolated from marine sponge Callyspongia sp. -derived fungus Aspergillus versicolour SCSIO XWS04 F52, which was identified on the basis of morphology and ITS sequence analysis. The planar structures of 1-3 were determined by spectroscopic (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), and MS analysis. Compounds 1 and 2 showed cytotoxic activity against leukaemia K562 and colon cancer cells SW111...
Source: Natural Product Research - November 7, 2023 Category: Biochemistry Authors: Mangaladoss Fredimoses Wen Ai Xiuping Lin Xuefeng Zhou Shengrong Liao Li Pan Yonghong Liu Source Type: research
Two new Aspera chaetominines A and B, and a new derivative of terrein, isolated from marine sponge associated fungus < em > Aspergillus versicolour < /em > SCSIO XWS04 F52
Nat Prod Res. 2023 Nov 7:1-13. doi: 10.1080/14786419.2023.2275744. Online ahead of print.ABSTRACTTwo new alkaloids, Aspera chaetominines A (1) and B (2), a new derivative (3) of terrein, and together with 11 known compounds (4-14) were isolated from marine sponge Callyspongia sp. -derived fungus Aspergillus versicolour SCSIO XWS04 F52, which was identified on the basis of morphology and ITS sequence analysis. The planar structures of 1-3 were determined by spectroscopic (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), and MS analysis. Compounds 1 and 2 showed cytotoxic activity against leukaemia K562 and colon cancer cells SW111...
Source: Natural Product Research - November 7, 2023 Category: Biochemistry Authors: Mangaladoss Fredimoses Wen Ai Xiuping Lin Xuefeng Zhou Shengrong Liao Li Pan Yonghong Liu Source Type: research
Superior anti-pulmonary viral potential of Natrialba sp. M6-producing surfactin and C50 carotenoid pigment with unveiling its action modes
CONCLUSION: This study declared the promising efficacy of Sur as an efficient pharmacological treatment option for these pulmonary viruses and considered as guide for further in vivo research.PMID:37904234 | DOI:10.1186/s12985-023-02215-8 (Source: Herpes)
Source: Herpes - October 31, 2023 Category: Infectious Diseases Authors: Ghada E Hegazy Marwa M Abu-Serie Nadia A Soliman Mohamed Teleb Yasser R Abdel-Fattah Source Type: research
Superior anti-pulmonary viral potential of Natrialba sp. M6-producing surfactin and C50 carotenoid pigment with unveiling its action modes
CONCLUSION: This study declared the promising efficacy of Sur as an efficient pharmacological treatment option for these pulmonary viruses and considered as guide for further in vivo research.PMID:37904234 | PMC:PMC10614327 | DOI:10.1186/s12985-023-02215-8 (Source: Herpes)
Source: Herpes - October 31, 2023 Category: Infectious Diseases Authors: Ghada E Hegazy Marwa M Abu-Serie Nadia A Soliman Mohamed Teleb Yasser R Abdel-Fattah Source Type: research
Viruses, Vol. 15, Pages 2198: Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing
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Bin Ma
Influenza A virus (IAV) is known to cause mild to severe respiratory illness. Under some conditions, the infection can lead to pneumonia (viral or bacterial), acute respiratory distress syndrome, and other complications that can be fatal, especially in vulnerable populations such as the elderly, young children, and individuals with underlying health conditions. Despite previous studies, little is known about the host immune response and neuroimmune interactions in IAV infection. Using RNA sequencing, we performed transcriptomic analysis of murine lung tissue 21 days post infection (dpi) with IAV (H1N1) in...
Source: Viruses - October 31, 2023 Category: Virology Authors: Huda A. M. Al-Shalan Dailun Hu Penghao Wang Jasim Uddin Abha Chopra Wayne K. Greene Bin Ma Tags: Article Source Type: research
VISN: virus instance segmentation network for TEM images using deep attention transformer
Brief Bioinform. 2023 Sep 22;24(6):bbad373. doi: 10.1093/bib/bbad373.ABSTRACTThe identification of viruses from negative staining transmission electron microscopy (TEM) images has mainly depended on experienced experts. Recent advances in artificial intelligence have enabled virus recognition using deep learning techniques. However, most of the existing methods only perform virus classification or semantic segmentation, and few studies have addressed the challenge of virus instance segmentation in TEM images. In this paper, we focus on the instance segmentation of severe acute respiratory syndrome coronavirus type 2 (SARS-...
Source: Briefings in Bioinformatics - October 30, 2023 Category: Bioinformatics Authors: Chi Xiao Jun Wang Shenrong Yang Minxin Heng Junyi Su Hao Xiao Jingdong Song Weifu Li Source Type: research
VISN: virus instance segmentation network for TEM images using deep attention transformer
Brief Bioinform. 2023 Sep 22;24(6):bbad373. doi: 10.1093/bib/bbad373.ABSTRACTThe identification of viruses from negative staining transmission electron microscopy (TEM) images has mainly depended on experienced experts. Recent advances in artificial intelligence have enabled virus recognition using deep learning techniques. However, most of the existing methods only perform virus classification or semantic segmentation, and few studies have addressed the challenge of virus instance segmentation in TEM images. In this paper, we focus on the instance segmentation of severe acute respiratory syndrome coronavirus type 2 (SARS-...
Source: Herpes - October 30, 2023 Category: Infectious Diseases Authors: Chi Xiao Jun Wang Shenrong Yang Minxin Heng Junyi Su Hao Xiao Jingdong Song Weifu Li Source Type: research
VISN: virus instance segmentation network for TEM images using deep attention transformer
Brief Bioinform. 2023 Sep 22;24(6):bbad373. doi: 10.1093/bib/bbad373.ABSTRACTThe identification of viruses from negative staining transmission electron microscopy (TEM) images has mainly depended on experienced experts. Recent advances in artificial intelligence have enabled virus recognition using deep learning techniques. However, most of the existing methods only perform virus classification or semantic segmentation, and few studies have addressed the challenge of virus instance segmentation in TEM images. In this paper, we focus on the instance segmentation of severe acute respiratory syndrome coronavirus type 2 (SARS-...
Source: Briefings in Bioinformatics - October 30, 2023 Category: Bioinformatics Authors: Chi Xiao Jun Wang Shenrong Yang Minxin Heng Junyi Su Hao Xiao Jingdong Song Weifu Li Source Type: research
VISN: virus instance segmentation network for TEM images using deep attention transformer
Brief Bioinform. 2023 Sep 22;24(6):bbad373. doi: 10.1093/bib/bbad373.ABSTRACTThe identification of viruses from negative staining transmission electron microscopy (TEM) images has mainly depended on experienced experts. Recent advances in artificial intelligence have enabled virus recognition using deep learning techniques. However, most of the existing methods only perform virus classification or semantic segmentation, and few studies have addressed the challenge of virus instance segmentation in TEM images. In this paper, we focus on the instance segmentation of severe acute respiratory syndrome coronavirus type 2 (SARS-...
Source: Briefings in Bioinformatics - October 30, 2023 Category: Bioinformatics Authors: Chi Xiao Jun Wang Shenrong Yang Minxin Heng Junyi Su Hao Xiao Jingdong Song Weifu Li Source Type: research
VISN: virus instance segmentation network for TEM images using deep attention transformer
Brief Bioinform. 2023 Sep 22;24(6):bbad373. doi: 10.1093/bib/bbad373.ABSTRACTThe identification of viruses from negative staining transmission electron microscopy (TEM) images has mainly depended on experienced experts. Recent advances in artificial intelligence have enabled virus recognition using deep learning techniques. However, most of the existing methods only perform virus classification or semantic segmentation, and few studies have addressed the challenge of virus instance segmentation in TEM images. In this paper, we focus on the instance segmentation of severe acute respiratory syndrome coronavirus type 2 (SARS-...
Source: Briefings in Bioinformatics - October 30, 2023 Category: Bioinformatics Authors: Chi Xiao Jun Wang Shenrong Yang Minxin Heng Junyi Su Hao Xiao Jingdong Song Weifu Li Source Type: research
VISN: virus instance segmentation network for TEM images using deep attention transformer
Brief Bioinform. 2023 Sep 22;24(6):bbad373. doi: 10.1093/bib/bbad373.ABSTRACTThe identification of viruses from negative staining transmission electron microscopy (TEM) images has mainly depended on experienced experts. Recent advances in artificial intelligence have enabled virus recognition using deep learning techniques. However, most of the existing methods only perform virus classification or semantic segmentation, and few studies have addressed the challenge of virus instance segmentation in TEM images. In this paper, we focus on the instance segmentation of severe acute respiratory syndrome coronavirus type 2 (SARS-...
Source: Briefings in Bioinformatics - October 30, 2023 Category: Bioinformatics Authors: Chi Xiao Jun Wang Shenrong Yang Minxin Heng Junyi Su Hao Xiao Jingdong Song Weifu Li Source Type: research
Viruses, Vol. 15, Pages 2176: Epidemiology of Influenza-like Illness and Respiratory Viral Etiology in Adult Patients in Taiyuan City, Shanxi Province, China between 2018 and 2019
This study provides a baseline epidemiological characterization of ILI and highlights the need for a nationwide detection and surveillance system for multiple respiratory pathogens. (Source: Viruses)
Source: Viruses - October 30, 2023 Category: Virology Authors: Zhao Jia Puna Xue Ruihong Gao Rui Wang Lifeng Zhao Zhihong Zuo Li Gao Rui Han Hong Yao Jiane Guo Jihong Xu Zhen Zhu Jitao Wang Tags: Article Source Type: research
