Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
P. Daulagala et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - December 18, 2023 Category: Infectious Diseases Source Type: research
Influenza Vaccination in Pregnancy —Rolling Up Sleeves for Pregnant Persons and Infants
As the world transitions from COVID-19 pandemic to endemic, influenza continues to adapt and challenge our immune systems and our public health initiatives. Influenza remains an important respiratory illness among all populations, including pregnant persons and infants, who both have increased susceptibility to severe disease. Notably, infants younger than 6 months have the highest hospitalization rate of all children. Maternal influenza vaccination protects expectant persons from illness and its complications as well as infants in the first 6 months of life through transplacental transfer of antibodies. The US Centers for...
Source: JAMA Pediatrics - December 18, 2023 Category: Pediatrics Source Type: research
Viruses, Vol. 15, Pages 2446: Genomic Analysis of Influenza A and B Viruses Carrying Baloxavir Resistance-Associated Substitutions Serially Passaged in Human Epithelial Cells
yushina
Baloxavir marboxil (baloxavir) is an FDA-approved inhibitor of the influenza virus polymerase acidic (PA) protein. Here, we used next-generation sequencing to compare the genomic mutational profiles of IAV H1N1 and H3N2, and IBV wild type (WT) and mutants (MUT) viruses carrying baloxavir resistance-associated substitutions (H1N1—PA I38L, I38T, and E199D; H3N2—PA I38T; and IBV—PA I38T) during passaging in normal human bronchial epithelial (NHBE) cells. We determined the ratio of nonsynonymous to synonymous nucleotide mutations (dN/dS) and identified the location and type...
Source: Viruses - December 16, 2023 Category: Virology Authors: Brady T. Hickerson Bruce K. Huang Svetlana N. Petrovskaya Natalia A. Ilyushina Tags: Article Source Type: research
Viruses, Vol. 15, Pages 2447: Pre-Clinical Evaluation of the Antiviral Activity of Epigalocatechin-3-Gallate, a Component of Green Tea, against Influenza A(H1N1)pdm Viruses
This study aimed to explore the antiviral efficacy of EGCG in vitro and in ferrets. We first performed studies in Madin-Darby Canine Kidney (MDCK) and human lung carcinoma (Calu-3) cells, which demonstrated antiviral activity. In MDCK cells, we observed a selective index (SI, CC50/IC50) of 77 (290 µM/3.8 µM) and 96 (290 µM/3.0 µM) against A/California/07/2009 and A/Victoria/2570/2019 (H1N1)pdm09 influenza virus, respectively. Calu-3 cells demonstrated a SI of 16 (420 µM/26 µM) and 18 (420 µM/24 µM). Ferrets infec...
Source: Viruses - December 16, 2023 Category: Virology Authors: Harry Stannard Paulina Koszalka Nikita Deshpande Yves Desjardins Mariana Baz Tags: Article Source Type: research
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
P. Daulagala et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - December 15, 2023 Category: Infectious Diseases Source Type: research
GSE230656 RNA sequencing of lungs from WT and GSDMD knockout mouse lungs after influenza virus H1N1 strain PR8 infection
Contributor : Jacob YountSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWT and GSDMD KO mice were infected with 50 TCID50 influenza virus strain PR8. 7 days post infection, RNA was extracted from lung tissue using TRIzol. RNA library preparation and sequencing was performed by Genewiz. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Influenza immune imprinting synergizes PEI-HA/CpG nanoparticle vaccine protection against heterosubtypic infection in mice
Vaccine. 2023 Dec 14:S0264-410X(23)01485-8. doi: 10.1016/j.vaccine.2023.12.039. Online ahead of print.ABSTRACTThe first influenza virus infection (imprinting) can lead to long-term immune memory and influence subsequent vaccinations and infections. Previously, we reported a polyethyleneimine (PEI)-Aichi hemagglutinin (HA)/CpG (PHC) nanoparticle with cross-protective potential against homologous and heterologous influenza strains. Here we studied how influenza immune imprinting influences the antibody responses to the PHC vaccination and the protection against heterosubtypic virus challenges. We found that pre-existing viru...
Source: Vaccine - December 14, 2023 Category: Allergy & Immunology Authors: Chunhong Dong Yao Ma Wandi Zhu Ye Wang Joo Kim Lai Wei Harvinder Singh Gill Sang-Moo Kang Bao-Zhong Wang Source Type: research
Influenza immune imprinting synergizes PEI-HA/CpG nanoparticle vaccine protection against heterosubtypic infection in mice
Vaccine. 2023 Dec 14:S0264-410X(23)01485-8. doi: 10.1016/j.vaccine.2023.12.039. Online ahead of print.ABSTRACTThe first influenza virus infection (imprinting) can lead to long-term immune memory and influence subsequent vaccinations and infections. Previously, we reported a polyethyleneimine (PEI)-Aichi hemagglutinin (HA)/CpG (PHC) nanoparticle with cross-protective potential against homologous and heterologous influenza strains. Here we studied how influenza immune imprinting influences the antibody responses to the PHC vaccination and the protection against heterosubtypic virus challenges. We found that pre-existing viru...
Source: Vaccine - December 14, 2023 Category: Allergy & Immunology Authors: Chunhong Dong Yao Ma Wandi Zhu Ye Wang Joo Kim Lai Wei Harvinder Singh Gill Sang-Moo Kang Bao-Zhong Wang Source Type: research
Epidemiological investigation of lower respiratory tract infections during influenza A (H1N1) pdm09 virus pandemic based on targeted next-generation sequencing
ConclusionDuring the current pandemic, the influenza A (H1N1) pdm09 virus may have been influenced by the SARS-CoV-2 pandemic and did not exhibit a strong pathogenicity. In fact, patients infected with influenza A virus showed better prognoses compared to those infected with other pathogens. Additionally, tNGS demonstrated excellent detection performance in this study and showed great potential, prompting clinical physicians to consider its use as an auxiliary diagnostic tool. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - December 14, 2023 Category: Microbiology Source Type: research
Fc γRIIB modulates splenic germinal center response against immune subversion during acute influenza A virus infection
CONCLUSION: Our research underscores the pivotal role of FcγRIIB in host defense and B cell-mediated immunity during acute IAV infection. Additionally, our discoveries hold implications for antiviral treatments, particularly during the initial stages of IAV infection, aimed at enhancing the host's humoral immune response.PMID:38087748 | DOI:10.1016/j.jmii.2023.11.007 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 13, 2023 Category: Microbiology Authors: Yu-Hsuan Wu Wan-Ting Chang Chia-Lang Hsu Yan-Fong Lu Jann-Tay Wang Shiang-Jong Tzeng Source Type: research
An experimental universal swine influenza a virus (IAV) vaccine candidate based on the M2 ectodomain (M2e) peptide does not provide protection against H1N1 IAV challenge in pigs
In conclusion, while the experimental IAV vaccine was able to induce anti-M2e antibodies, when challenged with H1N1, the vaccinated pigs were not protected, perhaps indicating that reactivity to the M2e antigen alone is not sufficient to reduce clinical signs, lesions or shedding associated with experimental IAV challenge.PMID:38087714 | DOI:10.1016/j.vaccine.2023.12.012 (Source: Vaccine)
Source: Vaccine - December 13, 2023 Category: Allergy & Immunology Authors: Tanja Opriessnig Phillip C Gauger Patricia Filippsen Favaro Gaurav Rawal Drew R Magstadt Paul Digard Hui-Min Lee Patrick G Halbur Source Type: research
Fc γRIIB modulates splenic germinal center response against immune subversion during acute influenza A virus infection
CONCLUSION: Our research underscores the pivotal role of FcγRIIB in host defense and B cell-mediated immunity during acute IAV infection. Additionally, our discoveries hold implications for antiviral treatments, particularly during the initial stages of IAV infection, aimed at enhancing the host's humoral immune response.PMID:38087748 | DOI:10.1016/j.jmii.2023.11.007 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 13, 2023 Category: Microbiology Authors: Yu-Hsuan Wu Wan-Ting Chang Chia-Lang Hsu Yan-Fong Lu Jann-Tay Wang Shiang-Jong Tzeng Source Type: research
An experimental universal swine influenza a virus (IAV) vaccine candidate based on the M2 ectodomain (M2e) peptide does not provide protection against H1N1 IAV challenge in pigs
In conclusion, while the experimental IAV vaccine was able to induce anti-M2e antibodies, when challenged with H1N1, the vaccinated pigs were not protected, perhaps indicating that reactivity to the M2e antigen alone is not sufficient to reduce clinical signs, lesions or shedding associated with experimental IAV challenge.PMID:38087714 | DOI:10.1016/j.vaccine.2023.12.012 (Source: Vaccine)
Source: Vaccine - December 13, 2023 Category: Allergy & Immunology Authors: Tanja Opriessnig Phillip C Gauger Patricia Filippsen Favaro Gaurav Rawal Drew R Magstadt Paul Digard Hui-Min Lee Patrick G Halbur Source Type: research
A novel “prime and pull” strategy mediated by the combination of two dendritic cell-targeting designs induced protective lung tissue-resident memory T cells against H1N1 influenza virus challenge
Vaccination is still the most promising strategy for combating influenza virus pandemics. However, the highly variable characteristics of influenza virus make it difficult to develop antibody-based universal v... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - December 13, 2023 Category: Nanotechnology Authors: Zhannan Wang, Yingkai He, Wenfeng Wang, Yawen Tian, Chongbo Ge, Futing Jia, Tongyu Zhang, Gerui Zhang, Mingyue Wang, Jinshuo Gong, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng & hellip; Tags: Research Source Type: research
COVID-19-Related School Closures, United States, July 27, 2020-June 30, 2022
Emerg Infect Dis. 2023 Dec 12;30(1). doi: 10.3201/eid3001.231215. Online ahead of print.ABSTRACTAs part of a multiyear project that monitored illness-related school closures, we conducted systematic daily online searches during July 27, 2020-June 30, 2022, to identify public announcements of COVID-19-related school closures (COVID-SCs) in the United States lasting >1 day. We explored the temporospatial patterns of COVID-SCs and analyzed associations between COVID-SCs and national COVID-19 surveillance data. COVID-SCs reflected national surveillance data: correlation was highest between COVID-SCs and both new PCR test po...
Source: Emerging Infectious Diseases - December 12, 2023 Category: Infectious Diseases Authors: Nicole Zviedrite Ferdous Jahan Sarah Moreland Faruque Ahmed Amra Uzicanin Source Type: research
