Evaluation of disease severity and prediction of severe cases in children hospitalized with influenza A (H1N1) infection during the post-COVID-19 era: a multicenter retrospective study
The rebound of influenza A (H1N1) infection in post-COVID-19 era recently attracted enormous attention due the rapidly increased number of pediatric hospitalizations and the changed characteristics compared to... (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 2, 2024 Category: Pediatrics Authors: Hai-Feng Liu, Xiao-Zhong Hu, Rong-Wei Huang, Zheng-Hong Guo, Jin-Rong Gao, Mei Xiang, Rui Lu, Deng Ban, Cong-Yun Liu, Ya-Yu Wang, Wang Li, Yin Li, Yun-Jie Guo, Quan Lu and Hong-Min Fu Tags: Research Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30;225:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruse...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Viruses, Vol. 16, Pages 548: Pandemic Risk Assessment for Swine Influenza A Virus in Comparative In Vitro and In Vivo Models
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Stephen Mark Tompkins
Swine influenza A viruses pose a public health concern as novel and circulating strains occasionally spill over into human hosts, with the potential to cause disease. Crucial to preempting these events is the use of a threat assessment framework for human populations. However, established guidelines do not specify which animal models or in vitro substrates should be used. We completed an assessment of a contemporary swine influenza isolate, A/swine/GA/A27480/2019 (H1N2), using animal models and human cell substrates. Infection studies in vivo revealed high replicative ability and a pathogeni...
Source: Viruses - March 31, 2024 Category: Virology Authors: Ian Padykula Lambodhar Damodaran Kelsey T. Young Madelyn Krunkosky Emily F. Griffin James F. North Peter J. Neasham Vasilis C. Pliasas Chris L. Siepker James B. Stanton Elizabeth W. Howerth Justin Bahl Constantinos S. Kyriakis Stephen Mark Tompkins Tags: Article Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
GSE189735 Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
Contributors : Benjamin F Koch ; Stephan PleschkaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInfluenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during IAV infection, correlating with an increased mortality. The aim of this study was to elucidate the interaction of IAV with human kidney cells and, thereby, to assess the mechanisms underlying IAV-mediated AKI. We demonstrate productive replication of low and highly pathogenic IAV strains on primary and im...
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study
ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 28, 2024 Category: Microbiology Source Type: research
Polylevodopa nanoplatform for lateral flow immunochromatography assay of SARS-CoV-2 and influenza A virus
Biochem Biophys Res Commun. 2024 Mar 23;709:149821. doi: 10.1016/j.bbrc.2024.149821. Online ahead of print.ABSTRACTAt the end of 2019, an unprecedented outbreak of novel coronavirus pneumonia ravaged the global landscape, inflicting profound harm upon society. Following numerous cycles of transmission, we find ourselves in an epoch where the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coexists alongside influenza viruses (Flu A). Swift and accurate diagnosis of SARS-CoV-2 and Flu A is imperative to stem the spread of these maladies and administer appropriate treatment. Presently, colloidal gold-based later...
Source: Biochemical and Biophysical Research communications - March 27, 2024 Category: Biochemistry Authors: Kangsong He Yabing Ye Shang Liu Pengcheng Yuan Wenjing Sun Jianbin Tang Source Type: research
Polylevodopa nanoplatform for lateral flow immunochromatography assay of SARS-CoV-2 and influenza A virus
Biochem Biophys Res Commun. 2024 Mar 23;709:149821. doi: 10.1016/j.bbrc.2024.149821. Online ahead of print.ABSTRACTAt the end of 2019, an unprecedented outbreak of novel coronavirus pneumonia ravaged the global landscape, inflicting profound harm upon society. Following numerous cycles of transmission, we find ourselves in an epoch where the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coexists alongside influenza viruses (Flu A). Swift and accurate diagnosis of SARS-CoV-2 and Flu A is imperative to stem the spread of these maladies and administer appropriate treatment. Presently, colloidal gold-based later...
Source: Biochemical and Biophysical Research communications - March 27, 2024 Category: Biochemistry Authors: Kangsong He Yabing Ye Shang Liu Pengcheng Yuan Wenjing Sun Jianbin Tang Source Type: research
