Superior anti-pulmonary viral potential of Natrialba sp. M6-producing surfactin and C50 carotenoid pigment with unveiling its action modes
Respiratory viruses, particularly adenoviruses (ADV), influenza A virus (e.g., H1N1), and coronaviruses (e.g., HCoV-229E and SARS-CoV-2) pose a global public health problem. Therefore, developing natural wide-... (Source: Virology Journal)
Source: Virology Journal - October 30, 2023 Category: Virology Authors: Ghada E. Hegazy, Marwa M. Abu-Serie, Nadia A. Soliman, Mohamed Teleb and Yasser R. Abdel-Fattah Tags: Research Source Type: research
The immune-adjunctive potential of recombinant LAB vector expressing murine IFN λ3 (MuIFNλ3) against Type A Influenza Virus (IAV) infection
ConclusionSince the primary target for IAV infections is the upper respiratory and gastrointestinal tract, immune activation without affecting the tissue homeostasis suggests the immune-adjunctive potential of IFN λ3 against IAV infections. (Source: Gut Pathogens)
Source: Gut Pathogens - October 30, 2023 Category: Microbiology Source Type: research
Rosmarinic acid treatment protects against lethal H1N1 virus-mediated inflammation and lung injury by promoting activation of the h-PGDS-PGD2-HO-1 signal axis
Rosmarinic acid (RosA) is a natural phenolic compound that possesses a wide-range of pharmacological properties. However, the effects of RosA on influenza A virus-mediated acute lung injury remain unknown. In ... (Source: Chinese Medicine)
Source: Chinese Medicine - October 27, 2023 Category: Complementary Medicine Authors: Beixian Zhou, Linxin Wang, Sushan Yang, Yueyun Liang, Yuehan Zhang, Xiping Pan and Jing Li Tags: Research Source Type: research
LSC - 2023 - In vitro modelling of respiratory infections in Idiopathic Pulmonary Fibrosis using patient-specific hiPSC-derived alveolar epithelial cells
Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease with a median survival of 2-3 years. Its etiology is unclear but environmental and genetic risk factors indicate that alveolar epithelial type 2 cells (AT2s) play a pivotal role. Mutations in surfactant protein (SP) genes compromise AT2s function and viability, reducing its capacity to regenerate damaged alveolar epithelial tissue. This function is further compromised by infection-induced lung injury. Environmental stimuli together with genetic predisposition in IPF patients result in an aberrant fibrotic response driven by AT2s. The study of ...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Serna Valverde, A. L., Reed, L., Cuevas Ocana, S., Kiu Lo, P. C., Tatler, A., Jenkins, G., Hannan, N. R. Tags: Molecular pathology and functional genomics Source Type: research
The in vivo antiviral efficacy of a novel inhalation drug candidate in a mouse treatment and post-exposure prophylaxis model
Conclusion: SS0330 shows virucidal effect in a murine influenza A treatment model, and Sendai post-exposure prophylaxis model. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Zhou, J., Jorgensen, E., Pravsgaard Christensen, J., Thuy Duong Le, M., Burton, C., Bjarnsholt, T. Tags: Respiratory infections and bronchiectasis Source Type: research
