Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus < em > Aspergillus candidus < /em > HDN15-152
Nat Prod Res. 2024 Mar 25:1-8. doi: 10.1080/14786419.2024.2333050. Online ahead of print.ABSTRACTOne new indole diterpenoid, ascandinine T (1), and three known analogues (2-4) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. All isolated compounds were tested for antiviral and anticancer activity. Compound 4 displayed antiviral activity against influenza A virus (IAV) of A/PR/8/34(H1N1) strain with an IC50 value of 39.2 μM, while compound 2 sh...
Source: Natural Product Research - March 25, 2024 Category: Biochemistry Authors: Bingying Tang Runfang Zhang Falei Zhang Tianjiao Zhu Qian Che Dehai Li Guojian Zhang Source Type: research
Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
DiscussionIAV not only infects, but also productively replicates on different human nephron cells. Importantly, multi-omics analysis revealed regulated cell death as potential contributing factor for the clinically observed kidney pathology in influenza. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 25, 2024 Category: Microbiology Source Type: research
Viral infections in pregnancy and impact on offspring neurodevelopment: mechanisms and lessons learned
Pediatr Res. 2024 Mar 20. doi: 10.1038/s41390-024-03145-z. Online ahead of print.ABSTRACTPregnant individuals with viral illness may experience significant morbidity and have higher rates of pregnancy and neonatal complications. With the growing number of viral infections and new viral pandemics, it is important to examine the effects of infection during pregnancy on both the gestational parent and the offspring. Febrile illness and inflammation during pregnancy are correlated with risk for autism, attention deficit/hyperactivity disorder, and developmental delay in the offspring in human and animal models. Historical vira...
Source: Pediatric Research - March 21, 2024 Category: Pediatrics Authors: Emma F Yates Sarah B Mulkey Source Type: research
Strengthening Pediatric and Public Health Collaboration to Protect Children ’s Health During a Pandemic
This article examines lessons learned from previous pandemics, including the 2009 H1N1 influenza and the coronavirus disease 2019 pandemic. Pediatric providers have a unique and important role and strategies to improve collaboration and communication between public health and pediatric providers are essential during public health emergencies. A robust network of communication channels, effective public health messaging, and pediatric-focused disease related, and program outcome data are key to supporting a coordinated response to future pandemics. Critical issues include real-time communication with and engagement of pedia...
Source: Pediatric Clinics of North America - March 21, 2024 Category: Pediatrics Authors: Zanah K. Francis, Elizabeth M. Dufort, Bernadette A. Albanese, Wendy M. Chung, Ellen H. Lee, Zack Moore, Laurene Mascola, Erica Pan, Caitlin Pedati, George Turabelidze, Sarah Y. Park Source Type: research
Differential detection of H1N1 virus spiker proteins by two hexaphenylbutadiene isomers based on size-matching principle
Anal Chim Acta. 2024 Apr 22;1299:342452. doi: 10.1016/j.aca.2024.342452. Epub 2024 Mar 5.ABSTRACTAs one of the high pathogenic influenza viruses, H1N1 virus easily induces to serious diseases, even leading to death. To date, all detection methods for H1N1 virus had shortcomings, including high equipment cost, time consumption, and etc. Therefore, a novel detection method should be established to achieve more convenient, rapid, and low-cost detection. In this work, an isomer of HPBmN-I with aggregation-induced emission characteristic was firstly synthesized on the basis of our previous reported HPBpN-I. The results showed t...
Source: Analytica Chimica Acta - March 18, 2024 Category: Chemistry Authors: Xiaoling Pan Jian Wang Kai Zhang Peng Sun Jianbing Shi Junge Zhi Zhengxu Cai Zi Li Dayan Wang Bin Tong Yuping Dong Source Type: research
Differential detection of H1N1 virus spiker proteins by two hexaphenylbutadiene isomers based on size-matching principle
Anal Chim Acta. 2024 Apr 22;1299:342452. doi: 10.1016/j.aca.2024.342452. Epub 2024 Mar 5.ABSTRACTAs one of the high pathogenic influenza viruses, H1N1 virus easily induces to serious diseases, even leading to death. To date, all detection methods for H1N1 virus had shortcomings, including high equipment cost, time consumption, and etc. Therefore, a novel detection method should be established to achieve more convenient, rapid, and low-cost detection. In this work, an isomer of HPBmN-I with aggregation-induced emission characteristic was firstly synthesized on the basis of our previous reported HPBpN-I. The results showed t...
Source: Analytica Chimica Acta - March 18, 2024 Category: Chemistry Authors: Xiaoling Pan Jian Wang Kai Zhang Peng Sun Jianbing Shi Junge Zhi Zhengxu Cai Zi Li Dayan Wang Bin Tong Yuping Dong Source Type: research
Differential detection of H1N1 virus spiker proteins by two hexaphenylbutadiene isomers based on size-matching principle
Anal Chim Acta. 2024 Apr 22;1299:342452. doi: 10.1016/j.aca.2024.342452. Epub 2024 Mar 5.ABSTRACTAs one of the high pathogenic influenza viruses, H1N1 virus easily induces to serious diseases, even leading to death. To date, all detection methods for H1N1 virus had shortcomings, including high equipment cost, time consumption, and etc. Therefore, a novel detection method should be established to achieve more convenient, rapid, and low-cost detection. In this work, an isomer of HPBmN-I with aggregation-induced emission characteristic was firstly synthesized on the basis of our previous reported HPBpN-I. The results showed t...
Source: Analytica Chimica Acta - March 18, 2024 Category: Chemistry Authors: Xiaoling Pan Jian Wang Kai Zhang Peng Sun Jianbing Shi Junge Zhi Zhengxu Cai Zi Li Dayan Wang Bin Tong Yuping Dong Source Type: research
Differential detection of H1N1 virus spiker proteins by two hexaphenylbutadiene isomers based on size-matching principle
Anal Chim Acta. 2024 Apr 22;1299:342452. doi: 10.1016/j.aca.2024.342452. Epub 2024 Mar 5.ABSTRACTAs one of the high pathogenic influenza viruses, H1N1 virus easily induces to serious diseases, even leading to death. To date, all detection methods for H1N1 virus had shortcomings, including high equipment cost, time consumption, and etc. Therefore, a novel detection method should be established to achieve more convenient, rapid, and low-cost detection. In this work, an isomer of HPBmN-I with aggregation-induced emission characteristic was firstly synthesized on the basis of our previous reported HPBpN-I. The results showed t...
Source: Analytica Chimica Acta - March 18, 2024 Category: Chemistry Authors: Xiaoling Pan Jian Wang Kai Zhang Peng Sun Jianbing Shi Junge Zhi Zhengxu Cai Zi Li Dayan Wang Bin Tong Yuping Dong Source Type: research
Correction: antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
(Source: Virology Journal)
Source: Virology Journal - March 18, 2024 Category: Virology Authors: Even Fossum, Andreas Rohringer, Torstein Aune, Kjersti Margrethe Rydland, Karoline Bragstad and Olav Hungnes Tags: Correction Source Type: research
TRIM21 reduces H1N1-induced inflammation and apoptosis by regulating the TBK1 –IRF3 signaling pathway in A549 cells
In this study, we investigated the role and molecular mechanism of TRIM21 in IAV infection. RT-qPCR was used to determine the level of TRIM21 mRNA, and ELISA was used to measure the levels of IFN- α, IFN-β, IL-6, and TNF-α. The levels of the TRIM21, NP, TBK1, IRF3, p-TBK1, and p-IRF3 proteins were estimated by Western blot. The results showed that, after IAV infection, TRIM21 was upregulated in clinical patient serum and A549 cells, and this was correlated with the IFN response. Overexpres sion of TRIM21 reduced IAV replication and transcription inin vitro cell experiments. TRIM21 also increased IFN- α and IFN-β level...
Source: Archives of Virology - March 13, 2024 Category: Virology Source Type: research
mRNA vaccines encoding computationally optimized hemagglutinin elicit protective antibodies against future antigenically drifted H1N1 and H3N2 influenza viruses isolated between 2018-2020
ConclusionsThis study highlights the potential benefits of combining universal influenza antigen design technology with modern vaccine delivery platforms and exhibits how these vaccines can be advantageous over traditional WT vaccine antigens at eliciting superior protective antibody responses against a broader number of influenza virus isolates. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 12, 2024 Category: Allergy & Immunology Source Type: research
The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease
Clin Immunol. 2024 Mar 7:110178. doi: 10.1016/j.clim.2024.110178. Online ahead of print.ABSTRACTControlling the excessive inflammatory response is one of the key ways to reduce the severity and mortality of severe influenza virus infections. RAGE is involved in inflammatory responses and acute lung injuries. Here, we investigated the role of RAGE and its potential application as a target for severe influenza treatment through serological correlation analysis for influenza patients, and treatment with the RAGE inhibitor FPS-ZM1 on A549 cells or mice with influenza A (H1N1) infection. The results showed high levels of RAGE w...
Source: Clinical Immunology - March 9, 2024 Category: Allergy & Immunology Authors: Wenhui Guo Junhao Luo Song Zhao Li Li Wenge Xing Rongbao Gao Source Type: research
The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease
Clin Immunol. 2024 Mar 7:110178. doi: 10.1016/j.clim.2024.110178. Online ahead of print.ABSTRACTControlling the excessive inflammatory response is one of the key ways to reduce the severity and mortality of severe influenza virus infections. RAGE is involved in inflammatory responses and acute lung injuries. Here, we investigated the role of RAGE and its potential application as a target for severe influenza treatment through serological correlation analysis for influenza patients, and treatment with the RAGE inhibitor FPS-ZM1 on A549 cells or mice with influenza A (H1N1) infection. The results showed high levels of RAGE w...
Source: Clinical Immunology - March 9, 2024 Category: Allergy & Immunology Authors: Wenhui Guo Junhao Luo Song Zhao Li Li Wenge Xing Rongbao Gao Source Type: research
Omics-based profiles and biomarkers of respiratory infections: are we there yet?
Extract
From the influenza pandemic of 1918–1919 to the most recent COVID-19 pandemic, respiratory infections remain a leading cause of mortality worldwide [1, 2]. Concurrently, the development of high-throughput omics technologies has revolutionised research about host responses to known and emerging respiratory pathogens [3], accelerating our understanding of highly prevalent pulmonary diseases [4]. Notably, omics technology-based characterisation of pathogens and host pathophysiology have critically supported diagnostic and therapeutic global health efforts during both the influenza A H1N1 and SARS-CoV-2 pandemics...
Source: European Respiratory Journal - March 7, 2024 Category: Respiratory Medicine Authors: Pantaleon Garcia, J., Evans, S. E. Tags: Editorials Source Type: research
Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies
CONCLUSIONS It seems important to determine whether the influenza virus strains tested for drug resistance as part of global influenza surveillance are equally representative of viruses circulating in populations with high and low vaccination rates, for all countries. Our results suggest that countries with low levels of influenza immunization may constitute reservoirs of drug-resistant influenza viruses.PMID:38446736 | DOI:10.12659/MSM.942125 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 6, 2024 Category: Research Authors: Ewelina Hallmann Aleksander Masny Anna Pozna ńska Francisco Pozo Inmaculada Casas Lidia Bernadeta Brydak Source Type: research
