An experimental universal swine influenza a virus (IAV) vaccine candidate based on the M2 ectodomain (M2e) peptide does not provide protection against H1N1 IAV challenge in pigs

In conclusion, while the experimental IAV vaccine was able to induce anti-M2e antibodies, when challenged with H1N1, the vaccinated pigs were not protected, perhaps indicating that reactivity to the M2e antigen alone is not sufficient to reduce clinical signs, lesions or shedding associated with experimental IAV challenge.PMID:38087714 | DOI:10.1016/j.vaccine.2023.12.012

Source: Vaccine - December 13, 2023 Category: Allergy & Immunology Authors: Tanja Opriessnig Phillip C Gauger Patricia Filippsen Favaro Gaurav Rawal Drew R Magstadt Paul Digard Hui-Min Lee Patrick G Halbur Source Type: research