A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno ‐Stimulating Effects
In this study, an immuno-stimulating antiviral system (ISAS) is introduced, which is composed of the immuno-stimulating adjuvant lipopeptide Pam3CSK4 that acts as a scaffold onto which it is covalently bound 3 to 4 influenza-inhibiting peptides. The multivalent display of peptides on the scaffold leads to a potent inhibition against H1N1 (EC50 = 20 nM). Importantly, the resulting lipopeptide, Pam3FDA, shows an irreversible inhibition mechanism. The chemical modification of peptides on the scaffold maintains Pam3CSK4's ability to stimulate dendritic cell maturation, thereby rendering Pam3FDA a unique antiviral. This is attributed to its immune activation capability, which also acts in synergy to expedite viral elimination.
Source: Small - Category: Nanotechnology Authors: Yong Zhu,
Lixia Wei,
Arnaud Charles ‐Antoine Zwygart,
Pablo Gaínza,
Quy Ong Khac,
Francesca Olgiati,
Armand Kurum,
Li Tang,
Bruno Correia,
Caroline Tapparel,
Francesco Stellacci Tags: Research Article Source Type: research