Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways
CONCLUSION: The amalgamation of the review underscores diosmetin's promising role as a multifaceted therapeutic agent, highlighting its potential for drug development and clinical applications.PMID:38629379 | DOI:10.2174/0109298665294109240323033601 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 17, 2024 Category: Biochemistry Authors: Krishna Kumar Varshney Jeetendra Kumar Gupta Rajnish Srivastava Source Type: research
Feasibility Study of Aesculus turbinata Fruit Shell-Derived Biochar for Ammonia Removal in Wastewater and Its Subsequent Use as Nitrogen Fertilizer
This study establishes the viability of utilizing ATFS-BC300 as a dual-purpose solution for wastewater treatment and nitrogen fertilizer supply, presenting a promising avenue for addressing environmental challenges.PMID:38631499 | DOI:10.1016/j.chemosphere.2024.142049 (Source: Chemosphere)
Source: Chemosphere - April 17, 2024 Category: Chemistry Authors: Jae-In Lee Chuluuntsetseg Jadamba Chang-Gu Lee Sung-Chang Hong Jin-Ho Kim Soo-Cheul Yoo Seong-Jik Park Source Type: research
Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage
This study employs both in vivo and in vitro models of cisplatin ototoxicity to explore this possibility. Our results reveal that hesperidin mitigates cisplatin-induced ototoxicity by activating the Nrf2/NQO1 pathway in sensory hair cells, thereby reducing ROS accumulation, preventing hair cell apoptosis, and alleviating hearing loss.PMID:38629504 | DOI:10.1080/13510002.2024.2341470 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Jintao Lou Fan Wu Wuhui He Rui Hu Ziyi Cai Guisheng Chen Wenji Zhao Zhigang Zhang Yu Si Source Type: research
Isoflavones isolated from the fruits of Ficus altissima and their anti-proliferative activities
In this study, we isolated and identified one new isoflavone (1), three new hydroxycoumaronochromones (2a, 2b and 3a) and 12 known compounds from the fruits of F. altissima. Their chemical structures were determined using spectroscopic analysis methods. We also tested all the isolated compounds for their anti-proliferative activities against eight human tumour cell lines (A-549, AGS, K562, K562/ADR, HepG2, HeLa, SPC-A-1 and CNE2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Our experiments showed that compound 6 exhibited obvious anti-proliferative activity against the K562 cell line...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yiliang Liu Yajing Pu Liyuan Shen Dan Li Jingwen Xu Xiangjiu He Yihai Wang Source Type: research
Feasibility Study of Aesculus turbinata Fruit Shell-Derived Biochar for Ammonia Removal in Wastewater and Its Subsequent Use as Nitrogen Fertilizer
This study establishes the viability of utilizing ATFS-BC300 as a dual-purpose solution for wastewater treatment and nitrogen fertilizer supply, presenting a promising avenue for addressing environmental challenges.PMID:38631499 | DOI:10.1016/j.chemosphere.2024.142049 (Source: Chemosphere)
Source: Chemosphere - April 17, 2024 Category: Chemistry Authors: Jae-In Lee Chuluuntsetseg Jadamba Chang-Gu Lee Sung-Chang Hong Jin-Ho Kim Soo-Cheul Yoo Seong-Jik Park Source Type: research
Cyclopeptide alkaloids from the Greek shrub < em > Paliurus spina < /em > - < em > christi < /em > and their < em > in silico < /em > binding affinity to Dipeptidyl Peptidase IV
Nat Prod Res. 2024 Apr 17:1-11. doi: 10.1080/14786419.2024.2340755. Online ahead of print.ABSTRACTA new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and ar...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Vaios Amountzias Dennis Abatis Antonios Drakopoulos Grigoris Zoidis Nektarios Aligiannis Source Type: research
The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort
CONCLUSION: Despite elevated prenatal THg exposure, no association was found with children's behavioural functioning assessed from early childhood to pre-adolescence. The nutrients in fish could offset the potential neurotoxic impact of Hg. Further birth cohort studies with longitudinal data are warranted.PMID:38631469 | DOI:10.1016/j.envres.2024.118954 (Source: Environmental Research)
Source: Environmental Research - April 17, 2024 Category: Environmental Health Authors: Blanca Sarzo Ferran Ballester Raquel Soler-Blasco Jordi Sunyer Maria-Jose Lopez-Espinosa Jesus Ibarluzea Manuel Lozano Jordi Julvez Gorka Iriarte Mikel Subiza-Perez Ll úcia González-Safont Ana Fern ández-Somoano Jorge Vallejo-Ortega M ònica Guxens Uli Source Type: research
Association between gardening activity and frailty in patients with heart failure
Conclusion Gardening activities were thus found to be associated with a low prevalence of frailty in patients with HF.PMID:38631852 | DOI:10.2169/internalmedicine.3628-24 (Source: Internal Medicine)
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Makoto Saito Masaki Kinoshita Takumi Sumimoto Tatsuro Tasaka Hirohiko Nakagawa Kaori Fujimoto Sumiko Sato Yuki Fujisawa Kazuhisa Nishimura Yoshihiro Miyake Osamu Yamaguchi Source Type: research
Influence of the use of remediated soil and agricultural drainage water on the safety of tomato fruits
In conclusion, the employed bioremediation techniques successfully reduced the PTE content and microbial load in both soil and drainage water ecosystems and in harvested tomato fruits. Henceforth, no health risks are expected from the consumption of this product.PMID:38632200 | DOI:10.1007/s11356-024-33187-z (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Salah H Salem Mohamed Saber Samir Gadow Hoda Kabary Alaa Zaghloul Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 17, 2024 Category: Neurology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Association between gardening activity and frailty in patients with heart failure
Conclusion Gardening activities were thus found to be associated with a low prevalence of frailty in patients with HF.PMID:38631852 | DOI:10.2169/internalmedicine.3628-24 (Source: Internal Medicine)
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Makoto Saito Masaki Kinoshita Takumi Sumimoto Tatsuro Tasaka Hirohiko Nakagawa Kaori Fujimoto Sumiko Sato Yuki Fujisawa Kazuhisa Nishimura Yoshihiro Miyake Osamu Yamaguchi Source Type: research
The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort
CONCLUSION: Despite elevated prenatal THg exposure, no association was found with children's behavioural functioning assessed from early childhood to pre-adolescence. The nutrients in fish could offset the potential neurotoxic impact of Hg. Further birth cohort studies with longitudinal data are warranted.PMID:38631469 | DOI:10.1016/j.envres.2024.118954 (Source: Environmental Research)
Source: Environmental Research - April 17, 2024 Category: Environmental Health Authors: Blanca Sarzo Ferran Ballester Raquel Soler-Blasco Jordi Sunyer Maria-Jose Lopez-Espinosa Jesus Ibarluzea Manuel Lozano Jordi Julvez Gorka Iriarte Mikel Subiza-Perez Ll úcia González-Safont Ana Fern ández-Somoano Jorge Vallejo-Ortega M ònica Guxens Uli Source Type: research
Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage
This study employs both in vivo and in vitro models of cisplatin ototoxicity to explore this possibility. Our results reveal that hesperidin mitigates cisplatin-induced ototoxicity by activating the Nrf2/NQO1 pathway in sensory hair cells, thereby reducing ROS accumulation, preventing hair cell apoptosis, and alleviating hearing loss.PMID:38629504 | PMC:PMC11025410 | DOI:10.1080/13510002.2024.2341470 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Jintao Lou Fan Wu Wuhui He Rui Hu Ziyi Cai Guisheng Chen Wenji Zhao Zhigang Zhang Yu Si Source Type: research
Isoflavones isolated from the fruits of Ficus altissima and their anti-proliferative activities
In this study, we isolated and identified one new isoflavone (1), three new hydroxycoumaronochromones (2a, 2b and 3a) and 12 known compounds from the fruits of F. altissima. Their chemical structures were determined using spectroscopic analysis methods. We also tested all the isolated compounds for their anti-proliferative activities against eight human tumour cell lines (A-549, AGS, K562, K562/ADR, HepG2, HeLa, SPC-A-1 and CNE2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Our experiments showed that compound 6 exhibited obvious anti-proliferative activity against the K562 cell line...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yiliang Liu Yajing Pu Liyuan Shen Dan Li Jingwen Xu Xiangjiu He Yihai Wang Source Type: research
