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Cyanidin-3-O-glucoside protects Zearalenone-induced in vitro maturation disorders of porcine oocytes by alleviating NOX4-dependent oxidative stress and endoplasmic reticulum stress in cumulus cells
In conclusion, C3G promoted in vitro maturation of porcine oocytes exposed to ZEN via mitigating NOX4-dependent oxidative stress and ERS in cumulus cells. These results contribute to our comprehension of the molecular mechanisms underlying the protective effects of C3G against ZEN toxicity in porcine oocytes, and they provide a novel theoretical foundation and strategy for future applications of C3G in the improvement of female reproduction.PMID:38688352 | DOI:10.1016/j.chemosphere.2024.142153 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Xiuxiu Li Yu Tian Ning Zuo Jiatian Tang Shunfeng Cheng Lan Li Jinghe Tan Jianxin Zhang Wei Shen Source Type: research

Partitioning recombinant chitinase from Nicotiana benthamiana by an aqueous two-phase system based on polyethylene glycol and phosphate salts
The objectives of this study were to purify 42 kDa chitinase derived from Trichoderma asperellum SH16 produced in Nicotiana benthamiana by a polyethylene glycol (PEG)/salt aqueous two-phase system (ATPS). The specific activities of the crude chitinase and the partially purified chitinase from N. benthamiana were about 251 unit/mg and 386 unit/mg, respectively. The study found the 300 g/L PEG 6000 + 200 g/L potassium phosphate (PP) and 300 g/L PEG 6000 + 150 g/L sodium phosphate (SP) systems had the highest partitioning efficiency for each salt in primary extraction. However, among the two types of salt, PP displayed higher...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Nguyen Hoang Tue Nguyen Hoang Phuc Phung Thi Bich Hoa Nguyen Quang Duc Tien Nguyen Hoang Loc Source Type: research

Effectiveness of Semecarpus anacardium fruits in cancer and inflammatory diseases: A mini review
CONCLUSION: The findings will provide more support for investigating SCA fruits in cancer treatment and will furnish thorough reference data and recommendations for future studies on this botanical medication.PMID:38685508 | DOI:10.1016/j.fitote.2024.105978 (Source: Fitoterapia)
Source: Fitoterapia - April 30, 2024 Category: Biochemistry Authors: Ashwini Kumar Mishra S L Neha Ankit Jain Chandrashekhar Y Jagtap Ganesh Dane Shweta Paroha Pravat Kumar Sahoo Source Type: research

Effectiveness of Gel from Andaliman Fruit ( Zanthoxylum acanthopodium DC.) Extract on Wound Inflammation
Conclusion: Finally, analgesic gel spray made from the Andaliman fruit at a 15% concentration can help with pain and also be antibacterial, reduce inflammation and help wounds heal.</p&gt.PMID:38686736 | DOI:10.3923/pjbs.2024.142.151 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Elsa Izza Sabila Annisa Ayu Ramadhani Hanif Fadhilah Balqis Nur Nasution None Fathiya Putri Cahaya Situmorang Source Type: research

Creating an explosion: Form and function in explosive fruit
Curr Opin Plant Biol. 2024 Apr 29;79:102543. doi: 10.1016/j.pbi.2024.102543. Online ahead of print.ABSTRACTAdaptations for seed dispersal are found everywhere in nature. However, only a fraction of this diversity is accessible through the study of model organisms. For example, Arabidopsis seeds are released by dehiscent fruit; and although many genes required for dehiscence have been identified, the genetic basis for the vast majority of seed dispersal strategies remains understudied. Explosive fruit generate mechanical forces to launch seeds over a wide area. Recent work indicates that key innovations required for explosi...
Source: Current Opinion in Plant Biology - April 30, 2024 Category: Biology Authors: Erin Cullen Angela Hay Source Type: research

Chemical Constituents of the Fruits of Cornus officinalis and Evaluation of Their Neuroprotective Activity
Chem Biodivers. 2024 Apr 30:e202400635. doi: 10.1002/cbdv.202400635. Online ahead of print.ABSTRACTThe phytochemical investigation of the fruits of Cornus officinalis yielded a new phenolic acid derivative, neophenolic acid A (1), and a novel flavonoid glycoside, (2R)-naringenin-7-O-β-(6″-galloyl-glucopyranoside) (2a), along with six known flavonoid glycosides (2b - 7). Their structures were determined by 1D, 2D NMR and HRESIMS data. The absolute configuration of 1 was established by ECD analysis. Compounds 1 - 7 were evaluated for their neuroprotective activities against corticosterone (CORT)-induced injury in PC-12 ce...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Meng Yang Zhi-You Hao Xiao-Lan Wang Shi-Qi Zhou Chao-Yuan Xiao Hui Chen Xiao-Ke Zheng Weisheng Feng Source Type: research

Wound Healing Activity of Topical Herbal Gels Containing Barringtonia acutangula Fruit Extract: In silico and In vivo Studies
Chem Biodivers. 2024 Apr 30:e202400147. doi: 10.1002/cbdv.202400147. Online ahead of print.ABSTRACTThe current study describes the efficacy of B. acutangula fruit extract in wound healing via incorporation within topical gels. B. acutangula fruit extract was produced by solvent extraction method. The bioactive extract was incorporated within Carbopol 940-based topical gels, which were applied topically over the excision and incision wounds. The change in healing process was observed till 20 days. The percentages of closure of excision wound area were 92.89% and 93.43%, when treated with topical herbal gels containing B. ac...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Kumari Priyanka Rudra Narayan Sahoo Ashirbad Nanda Satish Kanhar Chandan Das Abhijit Sahu Pradeep Kumar Naik Amit Kumar Nayak Source Type: research

The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study
CONCLUSION: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.PMID:38686701 | DOI:10.1210/clinem/dgae119 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Rebeca Eriksen Margaret C White Adem Y Dawed Isabel Garcia Perez Joram M Posma Mark Haid Sapna Sharma Cornelia Prehn Louise E Thomas Robert W Koivula Roberto Bizzotto Andrea Mari Giuseppe N Giordano Imre Pavo Jochen M Schwenk Federico De Masi Konstantinos Source Type: research

Does diet quality moderate the long-term effects of discrete but extreme PM 2.5 exposure on respiratory symptoms? A study of the Hazelwood coalmine fire
Environ Res. 2024 Apr 27:119014. doi: 10.1016/j.envres.2024.119014. Online ahead of print.ABSTRACTIn 2014, a fire at an open cut coalmine in regional Victoria, Australia burned for 6 weeks. Residents of the nearby town of Morwell were exposed to smoke, which included high levels of fine particulate matter (PM2.5). We investigated whether the long-term effects of PM2.5 on respiratory health were moderated by diet quality. A cross-sectional analysis was conducted of data collected 8.5 years after the mine fire from 282 residents of Morwell and 166 residents from the nearby unexposed town of Sale. Primary outcomes were respir...
Source: Environmental Research - April 30, 2024 Category: Environmental Health Authors: Thara Govindaraju Martin Man Alice J Owen Matthew Carroll Brigitte M Borg Catherine L Smith Caroline X Gao David Brown David Poland Shantelle Allgood Jillian F Ikin Michael J Abramson Tracy A McCaffrey Tyler J Lane Source Type: research