Pectin: Health-promoting properties as a natural galectin-3 inhibitor
AbstractGalectin-3 has a variety of important pathophysiological significance in the human body. Much evidence shows that the abnormal expression of galectin-3 is related to the formation and development of many diseases. Pectin is mostly obtained from processed citrus fruits and apples and is a known natural inhibitor of galactin-3. A large number of peels produced each year are discarded, and it is necessary to recycle some of the economically valuable active compounds in these by-products to reduce resource waste and environmental pollution. By binding with galectin-3, pectin can directly reduce the expression level of ...
Source: Glycoconjugate Journal - April 17, 2024 Category: Biochemistry Source Type: research
Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance
Environ Int. 2024 Apr 10;186:108626. doi: 10.1016/j.envint.2024.108626. Online ahead of print.ABSTRACTThe relationship of fine particulate matter (PM2.5) exposure and insulin resistance remains inclusive. Our study aimed to investigate this association in the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). Specifically, we examined the associations between long-term PM2.5 exposure and three surrogate indicators of insulin resistance: the triglyceride-glucose index (TyG), TyG with waist circumference (TyG-WC) and metabolic score for insulin resistance (METS-IR). Additionally, we e...
Source: Environment International - April 16, 2024 Category: Environmental Health Authors: Yanhui Jia Zhi He Fangchao Liu Jianxin Li Fengchao Liang Keyong Huang Jichun Chen Jie Cao Hongfan Li Chong Shen Ling Yu Xiaoqing Liu Dongsheng Hu Jianfeng Huang Yingxin Zhao Yang Liu Xiangfeng Lu Dongfeng Gu Shufeng Chen Source Type: research
Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4
This study characterized the O-dealkylated metabolite (M1) through chemical synthesis. The IC50 shift assay showed time-dependent inhibition of CYP3A4, 2C9, 2E1, 2C8 and 2D6 by PLG. This research contributes to the understanding of PLG-induced enzyme inhibition and bioactivation.PMID:38626834 | DOI:10.1016/j.ijbiomac.2024.131502 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Yuqian Chi Xiaoliang Zhu Yaxuan Chen Xin Li Ziyi Jiang Xiaoyang Jian Mengyuan Lian Xiaodi Wu Lei Wang Mengmeng Sun Xiaowei Shi Source Type: research
An outbreak of hepatitis E virus genotype 4d caused by consuming undercooked pig liver in a nursing home in Zhejiang Province, China
Int J Food Microbiol. 2024 Mar 25;417:110682. doi: 10.1016/j.ijfoodmicro.2024.110682. Online ahead of print.ABSTRACTHepatitis E infection is typically caused by contaminated water or food. In July and August 2022, an outbreak of hepatitis E was reported in a nursing home in Zhejiang Province, China. Local authorities and workers took immediate actions to confirm the outbreak, investigated the sources of infection and routes of transmission, took measures to terminate the outbreak, and summarized the lessons learned. An epidemiological investigation was conducted on all individuals in the nursing home, including demographic...
Source: International Journal of Food Microbiology - April 16, 2024 Category: Food Science Authors: Ziping Miao Kexin Cao Xiaoyue Wu Chenye Zhang Jian Gao Yin Chen Zhou Sun Xiaobin Ren Yijuan Chen Mengya Yang Can Chen Daixi Jiang Yuxia Du Xin Lv Shigui Yang Source Type: research
Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4
This study characterized the O-dealkylated metabolite (M1) through chemical synthesis. The IC50 shift assay showed time-dependent inhibition of CYP3A4, 2C9, 2E1, 2C8 and 2D6 by PLG. This research contributes to the understanding of PLG-induced enzyme inhibition and bioactivation.PMID:38626834 | DOI:10.1016/j.ijbiomac.2024.131502 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Yuqian Chi Xiaoliang Zhu Yaxuan Chen Xin Li Ziyi Jiang Xiaoyang Jian Mengyuan Lian Xiaodi Wu Lei Wang Mengmeng Sun Xiaowei Shi Source Type: research
Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance
Environ Int. 2024 Apr 10;186:108626. doi: 10.1016/j.envint.2024.108626. Online ahead of print.ABSTRACTThe relationship of fine particulate matter (PM2.5) exposure and insulin resistance remains inclusive. Our study aimed to investigate this association in the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). Specifically, we examined the associations between long-term PM2.5 exposure and three surrogate indicators of insulin resistance: the triglyceride-glucose index (TyG), TyG with waist circumference (TyG-WC) and metabolic score for insulin resistance (METS-IR). Additionally, we e...
Source: Environment International - April 16, 2024 Category: Environmental Health Authors: Yanhui Jia Zhi He Fangchao Liu Jianxin Li Fengchao Liang Keyong Huang Jichun Chen Jie Cao Hongfan Li Chong Shen Ling Yu Xiaoqing Liu Dongsheng Hu Jianfeng Huang Yingxin Zhao Yang Liu Xiangfeng Lu Dongfeng Gu Shufeng Chen Source Type: research
An outbreak of hepatitis E virus genotype 4d caused by consuming undercooked pig liver in a nursing home in Zhejiang Province, China
Int J Food Microbiol. 2024 Mar 25;417:110682. doi: 10.1016/j.ijfoodmicro.2024.110682. Online ahead of print.ABSTRACTHepatitis E infection is typically caused by contaminated water or food. In July and August 2022, an outbreak of hepatitis E was reported in a nursing home in Zhejiang Province, China. Local authorities and workers took immediate actions to confirm the outbreak, investigated the sources of infection and routes of transmission, took measures to terminate the outbreak, and summarized the lessons learned. An epidemiological investigation was conducted on all individuals in the nursing home, including demographic...
Source: International Journal of Food Microbiology - April 16, 2024 Category: Food Science Authors: Ziping Miao Kexin Cao Xiaoyue Wu Chenye Zhang Jian Gao Yin Chen Zhou Sun Xiaobin Ren Yijuan Chen Mengya Yang Can Chen Daixi Jiang Yuxia Du Xin Lv Shigui Yang Source Type: research
FirstStep2Health: A cluster randomised trial to promote healthy behaviours and prevent obesity amongst low ‐income preschoolers
ConclusionsEven with some potential limitations (small sample size, measurement concerns and confounding with Coronavirus Disease 2019 pandemic), the study's results support the preliminary efficacy of the FirstStep2Health intervention in preventing obesity amongst low-income racially diverse preschoolers. (Source: Pediatric Obesity)
Source: Pediatric Obesity - April 16, 2024 Category: Eating Disorders & Weight Management Authors: Jiying Ling,
Wachira Suriyawong,
Lorraine B. Robbins,
Nanhua Zhang,
Jean M. Kerver Tags: ORIGINAL RESEARCH Source Type: research
Fine mapping of TFL, a major gene regulating fruit length in snake gourd (Trichosanthes anguina L)
In this study, F2 snake gourd populations were generate... (Source: BMC Plant Biology)
Source: BMC Plant Biology - April 16, 2024 Category: Biology Authors: Qingwei Jiang, Peng Wang, Yuanchao Xu, Bingying Zou, Shishi Huang, Yuancai Wu, Yongqiang Li, Chuan Zhong and Wenjin Yu Tags: Research Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Impact of lactic acid bacteria inoculation on fungal diversity during Spanish-style green table olive fermentations
This study delved into the evolution of fungal population during the fermentation of Spanish-style green table olives (Manzanilla cultivar), determining the influence of different factors such as fermentation matrix (brine or fruit) or the use of a lactic acid bacteria inoculum, on its distribution. The samples (n = 24) were directly obtained from industrial fermentation vessels with approximately 10.000 kg of fruits and 6.000 L of brines. Our findings showcased a synchronized uptick in lactic acid bacteria counts alongside fungi proliferation. Metataxonomic analysis of the Internal Transcribed Spacer (ITS) region unearthe...
Source: International Journal of Food Microbiology - April 15, 2024 Category: Food Science Authors: Elio L ópez-García Ver ónica Romero-Gil Francisco No é Arroyo-López Antonio Ben ítez-Cabello Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Impact of lactic acid bacteria inoculation on fungal diversity during Spanish-style green table olive fermentations
This study delved into the evolution of fungal population during the fermentation of Spanish-style green table olives (Manzanilla cultivar), determining the influence of different factors such as fermentation matrix (brine or fruit) or the use of a lactic acid bacteria inoculum, on its distribution. The samples (n = 24) were directly obtained from industrial fermentation vessels with approximately 10.000 kg of fruits and 6.000 L of brines. Our findings showcased a synchronized uptick in lactic acid bacteria counts alongside fungi proliferation. Metataxonomic analysis of the Internal Transcribed Spacer (ITS) region unearthe...
Source: International Journal of Food Microbiology - April 15, 2024 Category: Food Science Authors: Elio L ópez-García Ver ónica Romero-Gil Francisco No é Arroyo-López Antonio Ben ítez-Cabello Source Type: research
