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Sinapic Acid Mitigates Pentylenetetrazol-induced Acute Seizures By Modulating the NLRP3 Inflammasome and Regulating Calcium/calcineurin Signaling: In Vivo and In Silico Approaches
AbstractSinapic acid (SA) is a naturally occurring carboxylic acid found in citrus fruits and cereals. Recent studies have shown that SA has potential anti-seizure properties due to its anti-inflammatory, antioxidant, and anti-apoptotic effects. The present study investigated the neuroprotective role of SA at two different dosages in a pentylenetetrazol (PTZ)-induced acute seizure model. Mice were divided into six groups: normal control, PTZ, SA (20 mg/kg), SA (20 mg/kg) + PTZ, SA (40 mg/kg), and SA (40 mg/kg) + PTZ. SA was orally administered for 21 days, followed by a convulsive dose of intraperitoneal PTZ ...
Source: Inflammation - April 25, 2024 Category: Allergy & Immunology Source Type: research

Actinidia arguta Extract Containing Myo -Inositol Suppresses TNF- α -Induced VCAM-1 Expression and Monocyte Adhesion to Endothelial Cells via Inhibition of the PTEN/Akt/GSK-3 β and NF- κ B Signaling Pathways
J Med Food. 2024 Apr 24. doi: 10.1089/jmf.2023.K.0326. Online ahead of print.ABSTRACTThe primary inflammatory process in atherosclerosis, a major contributor to cardiovascular disease, begins with monocyte adhering to vascular endothelial cells. Actinidia arguta (kiwiberry) is an edible fruit that contains various bioactive components. While A. arguta extract (AAE) has been recognized for its anti-inflammatory characteristics, its specific inhibitory effect on early atherogenic events has not been clarified. We used tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs) for an in vitro...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Jangho Lee Joon Park Kyung-Mo Song Yu Geon Lee Hyo-Kyoung Choi Source Type: research

Perceived coaches' health promotion activity, maintenance of participation in sports, and lifestyle habits among emerging adults: a four-year follow-up study
CONCLUSIONS: Perceiving coaches' health promotion activity as frequent was related to maintained participation in organized sports among males. Maintainers were more likely to have more healthy lifestyle habits than nonparticipants and dropouts. There is a need to invest in coaches' health promotion activity when it is infrequent. A more detailed understanding is needed of coaches' health promotion activity that supports both maintained participation in sports, especially among females, and healthy lifestyle habits in emerging adulthood.PMID:38658832 | DOI:10.1080/07853890.2024.2321327 (Source: Annals of Medicine)
Source: Annals of Medicine - April 24, 2024 Category: Internal Medicine Authors: Katja Rinta-Antila Pasi Koski Tuula Aira Olli J Heinonen Raija Korpelainen Jari Parkkari Kai Savonen Kerttu Toivo Arja Uusitalo Maarit Valtonen Tommi Vasankari Jari Villberg Sami Kokko Source Type: research

Recent Progress in Modified Atmosphere Packaging and Biopolymeric Films and Coatings for Fresh Strawberry Shelf ‐Life Extension
Fresh strawberries (FS) have a limited shelf life. Modified atmosphere packaging has been used to extend FS' shelf life. Biopolymeric films and coatings are technologies used to extent FS' shelf life. Active molecules have been used to manufacture films and coatings. ABSTRACTStrawberry (Fragaria × ananassa) is a valuable crop cultivated worldwide. This fruit is mainly consumed fresh and is an important source of vitamin C, fat-soluble vitamins and carotenoids. However, fresh strawberries (FS) have a limited shelf life. Conventionally, the shelf life of FS has been extended using refrigeration coupled with modified atmosph...
Source: Packaging Technology and Science - April 24, 2024 Category: Food Science Authors: Erika Paulsen, Sof ía Barrios, Nicolas Bogdanoff, Gabriel Coelho Leandro, Germán Ayala Valencia Tags: REVIEW ARTICLE Source Type: research

Tumours form without genetic mutations
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01019-2Researchers find that brief and reversible inhibition of a gene-silencing mechanism leads to irreversible tumour formation in fruit flies, challenging the idea that cancer is caused only by permanent changes to DNA. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Anne-Kathrin Classen Source Type: research

Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
by Archana Shrestha, Dipesh Tamrakar, Bhawana Ghinanju, Deepa Shrestha, Parashar Khadka, Bikram Adhikari, Jayana Shrestha, Suruchi Waiwa, Prajjwal Pyakurel, Niroj Bhandari, Biraj Man Karmacharya, Akina Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Vasanti Malik, Josiemer Mattei, Donna Spiegelman BackgroundWorksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. MethodsIn th...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Archana Shrestha Source Type: research

Development of natural dye photosensitizers for dye-sensitized solar cells: a review
Environ Sci Pollut Res Int. 2024 Apr 22. doi: 10.1007/s11356-024-33360-4. Online ahead of print.ABSTRACTDye-sensitized solar cell (DSSC) is a photovoltaic device that can be produced from natural source pigments or natural dyes. The selection of natural dyes for DSSC application is currently under research. The utilization of natural dye materials that are easy to obtain, cost-effective, and non-toxic can reduce waste during DSSC fabrication. Natural dyes can be extracted from plants through extraction and chromatography methods. The suitability and viability of utilizing natural dyes as photosensitizers in DSSCs can be pr...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Aripin Triyanto Nora'aini Ali Hasiah Salleh Jan Setiawan Norhafiza I Yatim Source Type: research

Glycaemic control among adults with type 2 diabetes mellitus in the Gulf Cooperation Council countries: an updated review
Endokrynol Pol. 2024 Apr 22. doi: 10.5603/ep.99519. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) has become a major public health concern, causing significant disability and death worldwide. Fuelled by a modern sedentary lifestyle and poor dietary practices, T2DM affects at least 10.5% of the world's population. This paper seeks to review the progress made by the Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) in addressing T2DM, focusing on glycaemic control proportions and comparing it with the 2015 review. The results indicate no signif...
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Ahmad Ali Alrasheedi Source Type: research

Development of natural dye photosensitizers for dye-sensitized solar cells: a review
Environ Sci Pollut Res Int. 2024 Apr 22. doi: 10.1007/s11356-024-33360-4. Online ahead of print.ABSTRACTDye-sensitized solar cell (DSSC) is a photovoltaic device that can be produced from natural source pigments or natural dyes. The selection of natural dyes for DSSC application is currently under research. The utilization of natural dye materials that are easy to obtain, cost-effective, and non-toxic can reduce waste during DSSC fabrication. Natural dyes can be extracted from plants through extraction and chromatography methods. The suitability and viability of utilizing natural dyes as photosensitizers in DSSCs can be pr...
Source: Environmental Science and Pollution Research International - April 22, 2024 Category: Environmental Health Authors: Aripin Triyanto Nora'aini Ali Hasiah Salleh Jan Setiawan Norhafiza I Yatim Source Type: research

Geniposide Attenuates Oxygen-glucose Deprivation/Recovery-induced Retinal Ganglion Cell Injury via Akt/Nrf-2 Signaling Pathway
CONCLUSION: Hence, it can be suggested that Gen provides neuroprotection against the OGD/R-induced injury of R28 cells by activating the Akt/Nrf-2 signaling pathway, which is beneficial for the clinical treatment of glaucoma.PMID:38644710 | DOI:10.2174/0109298673272406231212054710 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Minghai Hu Dekun Chen Xiuyu Wu Guo-Feng Ren Source Type: research

A tomato NAC transcription factor, SlNAP1, directly regulates gibberellin-dependent fruit ripening
Cell Mol Biol Lett. 2024 Apr 23;29(1):57. doi: 10.1186/s11658-024-00577-7.ABSTRACTIn tomato (Solanum lycopersicum), the ripening of fruit is regulated by the selective expression of ripening-related genes, and this procedure is controlled by transcription factors (TFs). In the various plant-specific TF families, the no apical meristem (NAM), Arabidopsis thaliana activating factor 1/2 (ATAF1/2), and cup-shaped cotyledon 2 (CUC2; NAC) TF family stands out and plays a significant function in plant physiological activities, such as fruit ripening (FR). Despite the numerous genes of NAC found in the tomato genome, limited infor...
Source: Cellular and Molecular Biology Letters - April 22, 2024 Category: Biochemistry Authors: Changxia Li Xuemei Hou Zongxi Zhao Huwei Liu Panpan Huang Meimei Shi Xuetong Wu Rong Gao Zhiya Liu Lijuan Wei Yihua Li Weibiao Liao Source Type: research