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Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 17, 2024 Category: Neurology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research

Association between gardening activity and frailty in patients with heart failure
Conclusion Gardening activities were thus found to be associated with a low prevalence of frailty in patients with HF.PMID:38631852 | DOI:10.2169/internalmedicine.3628-24 (Source: Internal Medicine)
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Makoto Saito Masaki Kinoshita Takumi Sumimoto Tatsuro Tasaka Hirohiko Nakagawa Kaori Fujimoto Sumiko Sato Yuki Fujisawa Kazuhisa Nishimura Yoshihiro Miyake Osamu Yamaguchi Source Type: research

Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage
This study employs both in vivo and in vitro models of cisplatin ototoxicity to explore this possibility. Our results reveal that hesperidin mitigates cisplatin-induced ototoxicity by activating the Nrf2/NQO1 pathway in sensory hair cells, thereby reducing ROS accumulation, preventing hair cell apoptosis, and alleviating hearing loss.PMID:38629504 | PMC:PMC11025410 | DOI:10.1080/13510002.2024.2341470 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Jintao Lou Fan Wu Wuhui He Rui Hu Ziyi Cai Guisheng Chen Wenji Zhao Zhigang Zhang Yu Si Source Type: research

GSE262759 Shared Transcriptomic Signatures of Inflammaging Among Diverse Strains of Drosophila melanogaster
Contributors : Sabrina I Perna ; Weihao Tang ; Andrew Li ; Sydney D Blimbaum ; Lei ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterBackground: A prominent hallmark of aging is inflammaging —the increased expression of innate immune genes without identifiable infection. Model organisms with shorter lifespans, such as the fruit fly, provide an essential platform for probing the mechanisms of inflammaging. Multiple groups have reported that, like mammalian models, old flies have signif icantly higher levels of expression of anti-microbial peptide genes. However, wheth...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research

Cancers, Vol. 16, Pages 1525: Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer
h Miskimins Elevated glucose uptake and production of lactate are common features of cancer cells. Among many tumor-promoting effects, lactate inhibits immune responses and is positively correlated with radioresistance. Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase that decreases lactate production. Quercetin is a flavonoid compound found in fruits and vegetables that inhibits glucose uptake and lactate export. We investigated the potential role and mechanisms of DCA, quercetin, and their combination, in the treatment of HPV-positive head and neck squamous cell carcinoma, an antigenic cancer su...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Yongxian Zhuang Joseph D. Coppock Allison B. Haugrud John H. Lee Shanta M. Messerli W. Keith Miskimins Tags: Article Source Type: research

Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF- β1/Smad2 signaling pathway
In conclusion, WSLE NE markedly enhanced the permeability of plant extract constituents through the blood brain barrier to boost its neuroprotective effect against PEN-induced neurotoxicity. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 17, 2024 Category: Drugs & Pharmacology Source Type: research

Association of sugary drinks, carbonated beverages, vegetable and fruit juices, sweetened and black coffee, and green tea with subsequent depression: a five-year cohort study
Evidence on the impact of beverage consumption on depression is limited in the Asian population. Specifically, there is little information available on vegetable and fruit juices, while whole vegetables and fruits are reportedly protective against depression. Furthermore, evidence is scarce in differentiating the impacts of sweetened and black coffee. We aimed to examine the association of the consumption of total sugary drinks, carbonated beverages, vegetable and fruit juices, sweetened and black coffee, and green tea with subsequent depression in a general population sample. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 17, 2024 Category: Nutrition Authors: Zui Narita, Shinsuke Hidese, Rieko Kanehara, Hisateru Tachimori, Hiroaki Hori, Yoshiharu Kim, Hiroshi Kunugi, Kazuhiko Arima, Satoshi Mizukami, Kozo Tanno, Nobuyuki Takanashi, Kazumasa Yamagishi, Isao Muraki, Nobufumi Yasuda, Isao Saito, Koutatsu Maruyama Source Type: research

Pectin: Health-promoting properties as a natural galectin-3 inhibitor
AbstractGalectin-3 has a variety of important pathophysiological significance in the human body. Much evidence shows that the abnormal expression of galectin-3 is related to the formation and development of many diseases. Pectin is mostly obtained from processed citrus fruits and apples and is a known natural inhibitor of galactin-3. A large number of peels produced each year are discarded, and it is necessary to recycle some of the economically valuable active compounds in these by-products to reduce resource waste and environmental pollution. By binding with galectin-3, pectin can directly reduce the expression level of ...
Source: Glycoconjugate Journal - April 17, 2024 Category: Biochemistry Source Type: research